| Character Description | Character Name |
| Is transgender. Got shot at prom | |
| Was a tough girl. Became lesbian with Paige. Became a stripper | |
| Is Muslim. Lost her virginity when 14. Runs away from home. | |
| Started LARPing. On and off with Sav. Befriends Riley. Develops cocaine addiction | |
| Was popular until she took ecstasy. On and off with Jimmy. Reunites with Craig and moves to Europe | |
| A slut, and boyfriend stealer. On and off with Drew | |
| He is a relaxed, artsy guy. Holly J. tries to have sex with him. | |
| Catches Dave pour urine on his locker. Throws a urine balloon at Dave. | |
| She is the writer of The Anti-Grape Vine Blog, and is known as the gossip queen of Degrassi. Captain of Power Squad | |
| Dates K.C., Eli, and Jake. Is Darcy's younger sister. | |
| Is diagnosed with Aspergers Syndrome. He starts to steal underwear from Miss Oh, Fiona, and other girls at Degrassi, which leads to him being suspended. | |
| Abused by dad. Is the lead singer of the band Downtown Sasquatch. Is bipolar | |
| He hooks up with Manny Santos the night of J.T.'s death. Cheats on Emma with Liberty | |
| Dates Leia and Chantay. Is Liberty's younger brother. | |
| Straight-laced Christian. Is Clare's older sister. Gets raped in season 7. Tries to commit suicide. | |
| Chantay's cousin. Pours urine on Bruce's locker. Is dating Alli | |
| Makes Peter get addicted to crystal meth. His sister kisses him. Tries to have sex with Holly J. | |
| Bullys Jane Vaughn. Is adopted | |
| On and off with Bianca. Develops posttraumatic stress disorder. Is Adam's stepbrother | |
| Taints Fitz's drink. Dates Clare and Imogen. Is bipolar | |
| Was Goth, Mom suffers from alcoholism. Kisses Craig | |
| Contracted gonorrhea. Had anorexia and bulimia. Has a pregnancy scare. Smokes weed. Marries Spinner | |
| Dates Adam, Riley, Bobby, and Charlie. Is lesbian and is in love with Holly J. | |
| Hates Alex Nunez. Dates Jimmy. Insecure about Muslim Heritage | |
| Dates Toby, Declan, and Blue. Best friends with Fiona. Has a kidney disease and needs a transplant. Is adopted. | |
| Stalks Eli. Is confused about her sexuality after kissing Fiona on the ferris wheel. | |
| Dates Clare and the two were about to have sex. Their parents were getting married. | |
| On and off with Liberty. Gets Liberty pregnant. Gets stabbed in his aorta by a Lakehurst student. | |
| He is involved with several illegal and inappropriate activities, such as stealing from Degrassi in season 3. Allows Emma to perform oral sex on him. | |