| Clue | Pope |
| pope when the Visigoths sacked Rome | |
| the current pope | |
| the last pope to crown the emperor at Rome | |
| the pope who lost control of Rome during the unification of Italy | |
| the last non-Italian pope before John Paul II | |
| the city prefect of Rome and a Doctor of the Church | |
| the pope who preached the Second Crusade | |
| the short-lived 'Smiling Pope' | |
| pope who was the illegitimate son of another pope | |
| the pope with the shortest reign | |
| the pope kidnapped by King Philip IV of France | |
| the last pope to take a new name before John Paul I | |
| the pope who patronized Bernini and persecuted Galileo | |
| the first pope after the end of the Great Schism of the West | |
| the pope in whose time Christianity became the official religion of the Roman Empire | |
| the first pope | |
| the pope who convinced Attila the Hun not to sack Rome | |
| the pope who presided over the peak of the Medieval Papacy and excommunicated King John of England | |
| the pope accused of incest with his daughter, Lucrezia Borgia | |
| the pope who crowned Napoleon | |
| the first Medici pope, who condemned Martin Luther | |
| the pope who three times excommunicated Emperor Frederick II | |
| the pope who formally protested the Peace of Westphalia | |
| the pope whose election resulted in the Great Schism of the West | |
| the pope who signed the Lateran Treaty with Mussolini, creating the Vatican City State | |
| the pope who suppressed the Jesuits | |
| the last pope to use his own name as his regnal name | |
| the pope who excommunicated Elizabeth I | |
| the pope who condemned the French Revolution | |
| the only Slavic pope | |