Oncogenic Effectors

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Can you name the oncogenic effectors?

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Cancer CausedGenes/EffectorsHints
Familial melanomaGene mutation
Familial Breast Cancer, OvarianGene mutation
Wilm's Tumorgene mutation, in kids
Chronic Myeloid Leukemia (CML)t(9;22), oncogene addiction
Hepatocellular carcinomaenvironmental
T Cell neoplasmsGene overexpression
Mantle Cell lymphomat(11;14), overexpress cyclin
Some leukemias and lymphomasinherited syndrome
Cervical CancerHPV genes
Retinoblastomagene mutation
Nasopharyngeal Cancersvirus
Some immunodeficiency statesgene mutation
Sporadic Breast Cancergene overexpression
Neurofibromatosis Type 1gene mutation
Liver cancertoxin from Aspergillus
Familial polyposis coligene mutation
Cervical CancerHPV types
Cancer CausedGenes/EffectorsHints
Liver angiosarcomaenvironmental
Follicular Lymphomat(14;18)
Li-Fraumeni Syndromegene mutation
Leukemias, thyroid, bone cancersenvironmental/occupational
Renal cancergene mutation, in adults
Burkitt Lymphomavirus
Acute Leukemiaenvironmental
Hereditary nonpolyposis colon cancermismatch DNA repair
T Cell leukemiavirus
Transcriptional Activationgeneral oncogene
Lung and Skin cancersenvironmental
Kaposi's Sarcoma (in AIDS)virus
Xeroderma Pigmentosum (skin cancer)general category of DNA repair
Gastric cancerbacteria
Hepatocellular CarcinomaResult of HBV liver damage

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