Oncogenic Effectors

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Can you name the oncogenic effectors?

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Cancer CausedGenes/EffectorsHints
Sporadic Breast Cancergene overexpression
Familial Breast Cancer, OvarianGene mutation
Chronic Myeloid Leukemia (CML)t(9;22), oncogene addiction
Kaposi's Sarcoma (in AIDS)virus
Hereditary nonpolyposis colon cancermismatch DNA repair
Gastric cancerbacteria
Follicular Lymphomat(14;18)
Acute Leukemiaenvironmental
Wilm's Tumorgene mutation, in kids
Cervical CancerHPV genes
Some leukemias and lymphomasinherited syndrome
Neurofibromatosis Type 1gene mutation
Renal cancergene mutation, in adults
Mantle Cell lymphomat(11;14), overexpress cyclin
Hepatocellular carcinomaenvironmental
Liver angiosarcomaenvironmental
Cancer CausedGenes/EffectorsHints
Familial melanomaGene mutation
T Cell leukemiavirus
Retinoblastomagene mutation
Familial polyposis coligene mutation
Burkitt Lymphomavirus
Nasopharyngeal Cancersvirus
Hepatocellular CarcinomaResult of HBV liver damage
Li-Fraumeni Syndromegene mutation
Xeroderma Pigmentosum (skin cancer)general category of DNA repair
T Cell neoplasmsGene overexpression
Leukemias, thyroid, bone cancersenvironmental/occupational
Liver cancertoxin from Aspergillus
Cervical CancerHPV types
Some immunodeficiency statesgene mutation
Lung and Skin cancersenvironmental
Transcriptional Activationgeneral oncogene

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