8b GUG

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QuestionAnswerNotes
Grading scheme for prostatic adenocarcinoma
MC neoplasm in young men
Tx of choice for vaginal atrophy
hormone causing ovulation
Tumor marker of seminoma
% of simple hyperplasia that progressed to cancer
MC cystic mass in reproductive-age women
Major SE of contraceptive implants
MCC male infertility in the world
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
MC STI
HTN after 20 wk w/o proteinuria
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
acute infection w/ obstruction -1st step?
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
'blue dot' sign and pain related to inflammation
Sv consequence of anovulatory cycle
Thin, long unilocular mass, associated with period
Malignant tumor of admixed proliferating trophoblasts, no villi
pain with sex
Targeted therapy for ER+ breast CA
Tx symptomatic bone mets (prostate CA)
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
Molecular? Type I, proliferative - simple hyperplasia
most prostate CA develops in which zone?
Chromosome 17, 85% lifetime breast Ca risk
MC site of involvement in endometriosis
postmenopausal, complex hyperplasia w/ atypia - tx?
Prevent sz in preeclampsia
% of complex atypical hyperplasia that progressed to cancer
Zone sampled in pap smear and biopsy
Kidney CA stage T4, invades
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Permanent cessation of menses x1yr w/ high FSH, low E2
IUD c/i in Wilson's disease
Composition of staghorn stone
Varicocele finding on U/S
Progestin in BCPs derived from spironolactone
'powder burn' lesions
Other name for ovarian fibroma
MC histiological subtype of endometrial CA
MC breast carcinoma in situ
Tumor marker for dysgerminoma
pau d' orange, cancer cells in dermal lymphatics
HTN after 20 wk gestation assoc w/ proteinuria
Best available protection against STIs
mech of finasteride, dutasteride
MC type of endometrial carcinoma
intraabdominal pregnancy, later found in a 60yo woman
antepartum hemorrhage after 20 wks
class of Rx for urge incontinence to tighten outlet
medical tx: urge incontinence
6 months w/o period
MC location of transitional cell cancer
Adnexal mass in reproductive age female, first r/o?
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
MC aneuploidy in abortuses
malignant germ cell tumor: AFP
Long acting Rx for ED
Appendix epididymis remnant of ?
Rx SE: PSA drops in half, ED, loss of libido
MC tumor of myometrium
HPV: Binds rB allowing for cell immortalization
dilatation of ducts, inspissated (thick) secretions
Induce fetal lung maturity - give mom ?
Papillary projections surrounded by Schiller-Duval bodies
Call-Exner bodies, Inhibin+
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
Still a cause of maternal and fetal death
HPV: Degrades p53 in the host cell
MC renal tumor
HRT: w/ uterus, need estrogen and ?
QuestionAnswerNotes
Rx w/ SE: endometrial polyps
Tumor marker of stromal cell tumors
Condition during lactation, mimics inflammatory breast cancer
beta 2 receptors cause uterine ?
Antigen that lyses seminal coagulum
Tx: tubal factor infertility
sudden huge increase in PSA likely due to?
MC ovarian germ cell tumor
exogenous testosterone leads to ? type of kidney stones
testicular torsion perinatal only
Tumor from dense fibroconnective tissue of the breast
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
Type of cancer after tx for mediastinal mass in college age woman
Mech: Change in transport speed of the ovum
Any condition irritating the periotoneal lining inc which marker?
MC infiltrating breast Ca
MC ovarian tumor (and cancer)
Dz: epidermis of nipple contains tumor cells
Most important reason fertility dec w/ female age is increasing ?
Molecular? Type I, simple - complex hyperplasia
Higher percent of free PSA (25%+)
oligohydramnios and 'key hole' sign
Bladder cancer sx in 85% of cases
MC trisomy in spontaneous abortion
low value w/ anovulation: failure to centrally stimulate follicular growth
Tumor marker for choriocarcinoma, embryonal carcinoma
Assoc w/ uterine hyperplasia/CA in postmenopausal women
MCC of amenorrhea (after pregnancy)
monoclonal ab to HER-2 neu
measure seminal vesciles - dilated due to?
Bilateral ovarian mets w/ signet ring
Lowest contraceptive failure rates
Removal of breast, pec minor and axillary lymph node
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
presence of endometrial glands in uterine myometrium
screening for nonpalpable breast masses
Origin of 90% ovarian cancers (aka MC form)
Most common estrogenic ovarian tumor
Tx PUV: Incise valve to damage leaflet
Stage: detected from elevated PSA alone, normal DRE & TRUS
Most important prognostic factor in breast Ca
% of complex hyperplasia that progressed to cancer
Class of Rx for urge incontinence to dec contractility
BPH Rx SE: orthostasis, dizziness, fall risk
intraurethral Rx for ED
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
2nd most common primary site of mets to ovary
Oral contraceptive in breastfeeding woman
Uterine size discrepant from dates
Colposcopy: cells w/ inc collagen turn white w/ ?
division of ovum after 13 days
male contraceptive = exogenous hormone?
elevated seminal leukocyte count aka?
umbilical cord inserts into the fetal membranes
Special type breast CA, high grade but good prognosis
Lady on tamoxifen w/ post-menopausal bleeding - next step?
Penile CA 0% in men who are ?
Infection causing bladder CA
MC group of aneuploidy in spont ab
L1 proteins from HPV strains self-assemble into non-infectious units called?
MC site to endometriosis
MC site of mets in metastatic breast cancer
Signet ring cells in ovary = ?
Endometrium that has been hormonally influenced by pregnancy
Main mode of spread of ovarian cancer
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Proper name for 'chocolate cyst'
malignant germ cell tumor: beta HCG
Sperm with DNA damage is assoc w/ ?
MC method of contraception
Endometrial glands/stroma implanted outside uterine cavity/walls
trophoblastic proliferation, fetus or fetal tissue present
QuestionAnswerNotes
MC histology of cervival CA
Renal CA assoc w/ Von Hippel-Lindau
breast path - clown face
Tx: stimulate ovary - induce endogenous FSH release
MCC UTO in male children
Marker WT-1
Mutation in mucinous ovarian tumors
MCC abnml uterine bleeding in adolescence
bleeding but os is open or closed, but still viable pregnancy
highest risk of prostate CA starting at what age?
Type II endometrial carcinoma assoc w/ ?
MC Tx of superficial bladder cancer
hypogonadotropic hypogonadism and anosmia
Flow of urine in retrograde fashion (to kidney) w/ voiding
Converts androgens to estrogen
Lab value inc if patient is not making sperm
Ovarian tumor w/ KRAS and BRAF mutations
Tumor marker for endodermal sinus tumor, embryonal carcinoma
% of simple atypical hyperplasia that progressed to cancer
#1 killer of neonates
Type of incontinence: outlet obstruction
hormonal therapy of metastatic breast Ca causing chemical castration
20-25% of adnexal masses, dx b/t age 10-30yo
Hallmark pathological finding of granulosa cell tumots
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
trophoblastic proliferation, cystic villi, no fetal tissue
Worst SE of Magnesium sulfate
Chromosome of BRCA-2
Cells that convert adrenal steroids to estrone
HTN dx in first 20 weeks of pregnancy
implantation into cornu of uterus or lower uterine segment
MCC abnml uterine bleeding in postmenopausal
Why is stage I breast Ca 10-year survival only 75%?
Chemo combo for advanced bladder CA
Breast duct/lobule cells that produce milk
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
MC gynecological CA worldwide
proliferation marker in endometrial cycle
MCC testis CA >50yo
Tx: antagonist in breast; agonist in endometrium
Perimenopausal uterine bleeding, first step?
MC site of ectopic pregnant
ovarian neoplasm w/ 3 germinal layers
Given to prevent CW recurrence at mastectomy site
MC benign growth in breast
best imaging modality for tubal infertility
Mutation assoc w/ high grade endometrioid tumors
e of incontinence: unstable bladder
abnormal dev of chorionic villi in pregnancy can become?
Targeted therapy for HER2+ breast CA
Amniotic Fluid Index >90th %ile
Rx: adjuvant therapy for ER+ premenopausal breast Ca
CA most strongly associated w/ obesity
first line hormonal therapy of metastatic breast Ca in postmeno
C/I for anticholinergic therapy
Type of incontinence: neurogenic dysfunction
Rx: adjuvant therapy for postmenopausal breast Ca
Syndrome: AD w/ 85% penetrance, BRCA
twins share chorion but one gets more blood flow
If surgery unavailable for testicular torson, reduce by twisting?
MCC Epididymal Orchitis in young men
MC testicular tumor
How to stage endometrial CA
reflex test to triage ASCUS pap smear in women > 21
Abnormally deep implantation onto the myometrium
MC composition of kidney stones
normal strict morphology required to bind to?
MC gynecologic CA
Appendix testes remnant of ?
first line hormonal therapy of metastatic breast Ca in premenopausal
Most important RF for uterine CA
tx: stress urinary incontinence that inc sphincter tone

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