8b GUG

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Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
HTN after 20 wk gestation assoc w/ proteinuria
Zone sampled in pap smear and biopsy
MC aneuploidy in abortuses
proliferation marker in endometrial cycle
MC infiltrating breast Ca
Proper name for 'chocolate cyst'
Prevent sz in preeclampsia
% of simple atypical hyperplasia that progressed to cancer
Tx PUV: Incise valve to damage leaflet
Bilateral ovarian mets w/ signet ring
medical tx: urge incontinence
twins share chorion but one gets more blood flow
MC site of mets in metastatic breast cancer
Most common estrogenic ovarian tumor
implantation into cornu of uterus or lower uterine segment
MC trisomy in spontaneous abortion
Syndrome: AD w/ 85% penetrance, BRCA
Tx: antagonist in breast; agonist in endometrium
Chromosome 17, 85% lifetime breast Ca risk
Main mode of spread of ovarian cancer
dilatation of ducts, inspissated (thick) secretions
trophoblastic proliferation, fetus or fetal tissue present
Assoc w/ uterine hyperplasia/CA in postmenopausal women
Varicocele finding on U/S
Sv consequence of anovulatory cycle
Tx of choice for vaginal atrophy
Type of incontinence: outlet obstruction
screening for nonpalpable breast masses
MCC testis CA >50yo
Cells that convert adrenal steroids to estrone
bleeding but os is open or closed, but still viable pregnancy
MC neoplasm in young men
most prostate CA develops in which zone?
Targeted therapy for ER+ breast CA
Class of Rx for urge incontinence to dec contractility
normal strict morphology required to bind to?
pain with sex
highest risk of prostate CA starting at what age?
Origin of 90% ovarian cancers (aka MC form)
If surgery unavailable for testicular torson, reduce by twisting?
Colposcopy: cells w/ inc collagen turn white w/ ?
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
CA most strongly associated w/ obesity
HTN dx in first 20 weeks of pregnancy
Molecular? Type I, simple - complex hyperplasia
Rx SE: PSA drops in half, ED, loss of libido
hormonal therapy of metastatic breast Ca causing chemical castration
Composition of staghorn stone
elevated seminal leukocyte count aka?
BPH Rx SE: orthostasis, dizziness, fall risk
hormone causing ovulation
Dz: epidermis of nipple contains tumor cells
Best available protection against STIs
Tumor marker for dysgerminoma
low value w/ anovulation: failure to centrally stimulate follicular growth
Mech: Change in transport speed of the ovum
MCC Epididymal Orchitis in young men
Induce fetal lung maturity - give mom ?
Targeted therapy for HER2+ breast CA
Type of cancer after tx for mediastinal mass in college age woman
MCC abnml uterine bleeding in adolescence
beta 2 receptors cause uterine ?
Oral contraceptive in breastfeeding woman
Other name for ovarian fibroma
Penile CA 0% in men who are ?
Rx: adjuvant therapy for ER+ premenopausal breast Ca
Progestin in BCPs derived from spironolactone
Appendix epididymis remnant of ?
HPV: Binds rB allowing for cell immortalization
Tx: tubal factor infertility
Worst SE of Magnesium sulfate
HTN after 20 wk w/o proteinuria
Tumor marker of seminoma
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
e of incontinence: unstable bladder
sudden huge increase in PSA likely due to?
20-25% of adnexal masses, dx b/t age 10-30yo
MC histiological subtype of endometrial CA
Tumor marker for choriocarcinoma, embryonal carcinoma
Antigen that lyses seminal coagulum
Why is stage I breast Ca 10-year survival only 75%?
6 months w/o period
MC site of ectopic pregnant
Papillary projections surrounded by Schiller-Duval bodies
MC renal tumor
Most important reason fertility dec w/ female age is increasing ?
MC cystic mass in reproductive-age women
Marker WT-1
mech of finasteride, dutasteride
IUD c/i in Wilson's disease
#1 killer of neonates
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
first line hormonal therapy of metastatic breast Ca in premenopausal
Rx: adjuvant therapy for postmenopausal breast Ca
% of complex hyperplasia that progressed to cancer
Most important RF for uterine CA
acute infection w/ obstruction -1st step?
Still a cause of maternal and fetal death
Adnexal mass in reproductive age female, first r/o?
MC composition of kidney stones
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
Lab value inc if patient is not making sperm
MC location of transitional cell cancer
Any condition irritating the periotoneal lining inc which marker?
oligohydramnios and 'key hole' sign
Removal of breast, pec minor and axillary lymph node
MC group of aneuploidy in spont ab
intraabdominal pregnancy, later found in a 60yo woman
HRT: w/ uterus, need estrogen and ?
Lowest contraceptive failure rates
malignant germ cell tumor: AFP
Tx: stimulate ovary - induce endogenous FSH release
MC gynecological CA worldwide
MC site to endometriosis
MC tumor of myometrium
hypogonadotropic hypogonadism and anosmia
Mutation in mucinous ovarian tumors
L1 proteins from HPV strains self-assemble into non-infectious units called?
Major SE of contraceptive implants
Endometrium that has been hormonally influenced by pregnancy
Given to prevent CW recurrence at mastectomy site
Long acting Rx for ED
reflex test to triage ASCUS pap smear in women > 21
first line hormonal therapy of metastatic breast Ca in postmeno
tx: stress urinary incontinence that inc sphincter tone
Rx w/ SE: endometrial polyps
Stage: detected from elevated PSA alone, normal DRE & TRUS
MCC male infertility in the world
Malignant tumor of admixed proliferating trophoblasts, no villi
Higher percent of free PSA (25%+)
Tumor from dense fibroconnective tissue of the breast
Thin, long unilocular mass, associated with period
Tumor marker for endodermal sinus tumor, embryonal carcinoma
MCC of amenorrhea (after pregnancy)
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Signet ring cells in ovary = ?
umbilical cord inserts into the fetal membranes
Endometrial glands/stroma implanted outside uterine cavity/walls
ovarian neoplasm w/ 3 germinal layers
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
% of simple hyperplasia that progressed to cancer
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
Grading scheme for prostatic adenocarcinoma
division of ovum after 13 days
Special type breast CA, high grade but good prognosis
Breast duct/lobule cells that produce milk
MCC abnml uterine bleeding in postmenopausal
MC histology of cervival CA
abnormal dev of chorionic villi in pregnancy can become?
MC testicular tumor
Sperm with DNA damage is assoc w/ ?
MC type of endometrial carcinoma
C/I for anticholinergic therapy
Condition during lactation, mimics inflammatory breast cancer
testicular torsion perinatal only
% of complex atypical hyperplasia that progressed to cancer
malignant germ cell tumor: beta HCG
monoclonal ab to HER-2 neu
best imaging modality for tubal infertility
Amniotic Fluid Index >90th %ile
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
Most important prognostic factor in breast Ca
Type II endometrial carcinoma assoc w/ ?
antepartum hemorrhage after 20 wks
Lady on tamoxifen w/ post-menopausal bleeding - next step?
MC ovarian germ cell tumor
Hallmark pathological finding of granulosa cell tumots
presence of endometrial glands in uterine myometrium
Type of incontinence: neurogenic dysfunction
Tx symptomatic bone mets (prostate CA)
Converts androgens to estrogen
MC site of involvement in endometriosis
HPV: Degrades p53 in the host cell
Ovarian tumor w/ KRAS and BRAF mutations
Kidney CA stage T4, invades
Flow of urine in retrograde fashion (to kidney) w/ voiding
2nd most common primary site of mets to ovary
Molecular? Type I, proliferative - simple hyperplasia
MC benign growth in breast
'blue dot' sign and pain related to inflammation
'powder burn' lesions
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
Chromosome of BRCA-2
MC breast carcinoma in situ
Bladder cancer sx in 85% of cases
male contraceptive = exogenous hormone?
Perimenopausal uterine bleeding, first step?
class of Rx for urge incontinence to tighten outlet
Tumor marker of stromal cell tumors
measure seminal vesciles - dilated due to?
intraurethral Rx for ED
Uterine size discrepant from dates
Permanent cessation of menses x1yr w/ high FSH, low E2
MC gynecologic CA
Appendix testes remnant of ?
Chemo combo for advanced bladder CA
exogenous testosterone leads to ? type of kidney stones
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
MC Tx of superficial bladder cancer
Renal CA assoc w/ Von Hippel-Lindau
Abnormally deep implantation onto the myometrium
postmenopausal, complex hyperplasia w/ atypia - tx?
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Call-Exner bodies, Inhibin+
MC ovarian tumor (and cancer)
How to stage endometrial CA
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
pau d' orange, cancer cells in dermal lymphatics
breast path - clown face
Infection causing bladder CA
MC method of contraception
Mutation assoc w/ high grade endometrioid tumors
MCC UTO in male children
trophoblastic proliferation, cystic villi, no fetal tissue

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