8b GUG

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MC site of involvement in endometriosis
MCC abnml uterine bleeding in postmenopausal
MCC male infertility in the world
Composition of staghorn stone
Tx of choice for vaginal atrophy
Chromosome 17, 85% lifetime breast Ca risk
Rx SE: PSA drops in half, ED, loss of libido
Renal CA assoc w/ Von Hippel-Lindau
Targeted therapy for HER2+ breast CA
Type II endometrial carcinoma assoc w/ ?
MC site to endometriosis
Tumor from dense fibroconnective tissue of the breast
Major SE of contraceptive implants
L1 proteins from HPV strains self-assemble into non-infectious units called?
intraurethral Rx for ED
MC tumor of myometrium
Dz: epidermis of nipple contains tumor cells
MC location of transitional cell cancer
MC trisomy in spontaneous abortion
Class of Rx for urge incontinence to dec contractility
HPV: Binds rB allowing for cell immortalization
Molecular? Type I, simple - complex hyperplasia
Condition during lactation, mimics inflammatory breast cancer
hormonal therapy of metastatic breast Ca causing chemical castration
Induce fetal lung maturity - give mom ?
Type of cancer after tx for mediastinal mass in college age woman
MC group of aneuploidy in spont ab
trophoblastic proliferation, fetus or fetal tissue present
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
Converts androgens to estrogen
Amniotic Fluid Index >90th %ile
Ovarian tumor w/ KRAS and BRAF mutations
#1 killer of neonates
Hallmark pathological finding of granulosa cell tumots
Stage: detected from elevated PSA alone, normal DRE & TRUS
Antigen that lyses seminal coagulum
MC infiltrating breast Ca
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
Why is stage I breast Ca 10-year survival only 75%?
Special type breast CA, high grade but good prognosis
Infection causing bladder CA
20-25% of adnexal masses, dx b/t age 10-30yo
pau d' orange, cancer cells in dermal lymphatics
MC histiological subtype of endometrial CA
Prevent sz in preeclampsia
Still a cause of maternal and fetal death
Signet ring cells in ovary = ?
MCC Epididymal Orchitis in young men
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
'blue dot' sign and pain related to inflammation
MCC of amenorrhea (after pregnancy)
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
MCC abnml uterine bleeding in adolescence
Rx: adjuvant therapy for postmenopausal breast Ca
normal strict morphology required to bind to?
Syndrome: AD w/ 85% penetrance, BRCA
MC type of endometrial carcinoma
Penile CA 0% in men who are ?
Cells that convert adrenal steroids to estrone
Sperm with DNA damage is assoc w/ ?
Adnexal mass in reproductive age female, first r/o?
postmenopausal, complex hyperplasia w/ atypia - tx?
Call-Exner bodies, Inhibin+
presence of endometrial glands in uterine myometrium
Most common estrogenic ovarian tumor
twins share chorion but one gets more blood flow
Tx: tubal factor infertility
Best available protection against STIs
Appendix epididymis remnant of ?
exogenous testosterone leads to ? type of kidney stones
% of simple hyperplasia that progressed to cancer
class of Rx for urge incontinence to tighten outlet
Rx w/ SE: endometrial polyps
e of incontinence: unstable bladder
Papillary projections surrounded by Schiller-Duval bodies
Most important reason fertility dec w/ female age is increasing ?
MC aneuploidy in abortuses
oligohydramnios and 'key hole' sign
abnormal dev of chorionic villi in pregnancy can become?
Tumor marker of stromal cell tumors
first line hormonal therapy of metastatic breast Ca in postmeno
MC breast carcinoma in situ
Appendix testes remnant of ?
division of ovum after 13 days
Grading scheme for prostatic adenocarcinoma
HTN after 20 wk gestation assoc w/ proteinuria
most prostate CA develops in which zone?
Tx: stimulate ovary - induce endogenous FSH release
Malignant tumor of admixed proliferating trophoblasts, no villi
Zone sampled in pap smear and biopsy
Progestin in BCPs derived from spironolactone
MC site of ectopic pregnant
low value w/ anovulation: failure to centrally stimulate follicular growth
measure seminal vesciles - dilated due to?
malignant germ cell tumor: beta HCG
% of simple atypical hyperplasia that progressed to cancer
MCC UTO in male children
Colposcopy: cells w/ inc collagen turn white w/ ?
CA most strongly associated w/ obesity
HPV: Degrades p53 in the host cell
% of complex hyperplasia that progressed to cancer
dilatation of ducts, inspissated (thick) secretions
antepartum hemorrhage after 20 wks
MC method of contraception
highest risk of prostate CA starting at what age?
Targeted therapy for ER+ breast CA
How to stage endometrial CA
HTN dx in first 20 weeks of pregnancy
% of complex atypical hyperplasia that progressed to cancer
'powder burn' lesions
hormone causing ovulation
Tumor marker for dysgerminoma
IUD c/i in Wilson's disease
Type of incontinence: neurogenic dysfunction
malignant germ cell tumor: AFP
Endometrium that has been hormonally influenced by pregnancy
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
Varicocele finding on U/S
Breast duct/lobule cells that produce milk
Most important prognostic factor in breast Ca
Mutation assoc w/ high grade endometrioid tumors
beta 2 receptors cause uterine ?
MC histology of cervival CA
MC gynecologic CA
Worst SE of Magnesium sulfate
MC cystic mass in reproductive-age women
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
Molecular? Type I, proliferative - simple hyperplasia
Tumor marker for endodermal sinus tumor, embryonal carcinoma
Mutation in mucinous ovarian tumors
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
sudden huge increase in PSA likely due to?
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Lady on tamoxifen w/ post-menopausal bleeding - next step?
MC gynecological CA worldwide
implantation into cornu of uterus or lower uterine segment
Most important RF for uterine CA
breast path - clown face
screening for nonpalpable breast masses
Tx: antagonist in breast; agonist in endometrium
MC ovarian tumor (and cancer)
Bilateral ovarian mets w/ signet ring
C/I for anticholinergic therapy
Chromosome of BRCA-2
2nd most common primary site of mets to ovary
Any condition irritating the periotoneal lining inc which marker?
Other name for ovarian fibroma
monoclonal ab to HER-2 neu
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Lab value inc if patient is not making sperm
male contraceptive = exogenous hormone?
umbilical cord inserts into the fetal membranes
elevated seminal leukocyte count aka?
MC Tx of superficial bladder cancer
Assoc w/ uterine hyperplasia/CA in postmenopausal women
MC benign growth in breast
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
Tumor marker for choriocarcinoma, embryonal carcinoma
Higher percent of free PSA (25%+)
tx: stress urinary incontinence that inc sphincter tone
Type of incontinence: outlet obstruction
Given to prevent CW recurrence at mastectomy site
Permanent cessation of menses x1yr w/ high FSH, low E2
first line hormonal therapy of metastatic breast Ca in premenopausal
Proper name for 'chocolate cyst'
MC composition of kidney stones
hypogonadotropic hypogonadism and anosmia
Bladder cancer sx in 85% of cases
testicular torsion perinatal only
Uterine size discrepant from dates
pain with sex
Mech: Change in transport speed of the ovum
Sv consequence of anovulatory cycle
Tx PUV: Incise valve to damage leaflet
MC site of mets in metastatic breast cancer
Rx: adjuvant therapy for ER+ premenopausal breast Ca
Long acting Rx for ED
Kidney CA stage T4, invades
Oral contraceptive in breastfeeding woman
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
Main mode of spread of ovarian cancer
Thin, long unilocular mass, associated with period
Abnormally deep implantation onto the myometrium
Endometrial glands/stroma implanted outside uterine cavity/walls
best imaging modality for tubal infertility
Flow of urine in retrograde fashion (to kidney) w/ voiding
medical tx: urge incontinence
BPH Rx SE: orthostasis, dizziness, fall risk
trophoblastic proliferation, cystic villi, no fetal tissue
Tx symptomatic bone mets (prostate CA)
ovarian neoplasm w/ 3 germinal layers
MC testicular tumor
bleeding but os is open or closed, but still viable pregnancy
MC renal tumor
6 months w/o period
Origin of 90% ovarian cancers (aka MC form)
Removal of breast, pec minor and axillary lymph node
proliferation marker in endometrial cycle
Perimenopausal uterine bleeding, first step?
Marker WT-1
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?
MC neoplasm in young men
If surgery unavailable for testicular torson, reduce by twisting?
acute infection w/ obstruction -1st step?
HTN after 20 wk w/o proteinuria
reflex test to triage ASCUS pap smear in women > 21
intraabdominal pregnancy, later found in a 60yo woman
mech of finasteride, dutasteride
Lowest contraceptive failure rates
HRT: w/ uterus, need estrogen and ?
Chemo combo for advanced bladder CA
MC ovarian germ cell tumor
MCC testis CA >50yo
Tumor marker of seminoma

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