8b GUG

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Can you name the 8b GUG?

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Mutation assoc w/ high grade endometrioid tumors
C/I for anticholinergic therapy
low value w/ anovulation: failure to centrally stimulate follicular growth
'blue dot' sign and pain related to inflammation
Varicocele finding on U/S
Targeted therapy for HER2+ breast CA
Any condition irritating the periotoneal lining inc which marker?
Endometrial glands/stroma implanted outside uterine cavity/walls
#1 killer of neonates
pain with sex
Most common estrogenic ovarian tumor
first line hormonal therapy of metastatic breast Ca in premenopausal
Cells that convert adrenal steroids to estrone
L1 proteins from HPV strains self-assemble into non-infectious units called?
umbilical cord inserts into the fetal membranes
Contraceptive w/ SE: irregular bleeding, weight gain, bone loss
MC histiological subtype of endometrial CA
hypogonadotropic hypogonadism and anosmia
Mech: Change in transport speed of the ovum
Flow of urine in retrograde fashion (to kidney) w/ voiding
Tumor marker for dysgerminoma
MC histology of cervival CA
reflex test to triage ASCUS pap smear in women > 21
Higher percent of free PSA (25%+)
Most important RF for uterine CA
Permanent cessation of menses x1yr w/ high FSH, low E2
HPV: Binds rB allowing for cell immortalization
Condition during lactation, mimics inflammatory breast cancer
Syndrome: AD w/ 85% penetrance, BRCA
% of complex atypical hyperplasia that progressed to cancer
Tumor marker for endodermal sinus tumor, embryonal carcinoma
MCC testis CA >50yo
Tumor marker for choriocarcinoma, embryonal carcinoma
Signet ring cells in ovary = ?
MC type of endometrial carcinoma
Grading scheme for prostatic adenocarcinoma
dilatation of ducts, inspissated (thick) secretions
twins share chorion but one gets more blood flow
Tx: antagonist in breast; agonist in endometrium
hormone causing ovulation
Classic path change - failure of conversion of maternal vessels from low volume-high resistance to a high volume-low resistance system
MC infiltrating breast Ca
20-25% of adnexal masses, dx b/t age 10-30yo
trophoblastic proliferation, fetus or fetal tissue present
Given to prevent CW recurrence at mastectomy site
elevated seminal leukocyte count aka?
Perimenopausal uterine bleeding, first step?
tx: stress urinary incontinence that inc sphincter tone
Proper name for 'chocolate cyst'
Molecular? Type I, proliferative - simple hyperplasia
Abnormally deep implantation onto the myometrium
HRT: w/ uterus, need estrogen and ?
MC breast carcinoma in situ
medical tx: urge incontinence
Tx: stimulate ovary - induce endogenous FSH release
Antigen that lyses seminal coagulum
IUD c/i in Wilson's disease
Long acting Rx for ED
% of complex hyperplasia that progressed to cancer
pau d' orange, cancer cells in dermal lymphatics
oligohydramnios and 'key hole' sign
Best available protection against STIs
Tumor marker of stromal cell tumors
bleeding but os is open or closed, but still viable pregnancy
Inc prolif of glands rel to stroma 2/2 inactivation of ? gene
2nd most common primary site of mets to ovary
Marker WT-1
Induce fetal lung maturity - give mom ?
Still a cause of maternal and fetal death
HTN dx in first 20 weeks of pregnancy
MC site of mets in metastatic breast cancer
6 months w/o period
Rx SE: PSA drops in half, ED, loss of libido
Assoc w/ uterine hyperplasia/CA in postmenopausal women
Type of incontinence: neurogenic dysfunction
MC group of aneuploidy in spont ab
Deletion or unbalanced translocation of chromosome 3 (VKL gene)
Endometrium that has been hormonally influenced by pregnancy
Adnexal mass in reproductive age female, first r/o?
Most important prognostic factor in breast Ca
proliferation marker in endometrial cycle
MC benign growth in breast
testicular torsion perinatal only
Oral contraceptive in breastfeeding woman
acute infection w/ obstruction -1st step?
Rx: adjuvant therapy for ER+ premenopausal breast Ca
MC renal tumor
division of ovum after 13 days
MCC abnml uterine bleeding in adolescence
Progestin in BCPs derived from spironolactone
Chromosome of BRCA-2
Lowest contraceptive failure rates
Rx: adjuvant therapy for postmenopausal breast Ca
Rx w/ SE: endometrial polyps
MC Tx of superficial bladder cancer
malignant germ cell tumor: beta HCG
Contraception w/ dec efficacy at higher BMI i.e. >198 lbs
Sv consequence of anovulatory cycle
Composition of staghorn stone
Thin, long unilocular mass, associated with period
Appendix epididymis remnant of ?
most prostate CA develops in which zone?
Syndrome w/ inc risk of colon, ovarian, endometrial, breast and uroepithelial CA
best imaging modality for tubal infertility
highest risk of prostate CA starting at what age?
HPV: Degrades p53 in the host cell
Hemangioblastoma of cerebellum and retina, renal cysts and RCC
CA most strongly associated w/ obesity
MC method of contraception
Removal of breast, pec minor and axillary lymph node
Most important reason fertility dec w/ female age is increasing ?
MC cystic mass in reproductive-age women
MC composition of kidney stones
Tumor marker of seminoma
Type II endometrial carcinoma assoc w/ ?
Prevent sz in preeclampsia
first line hormonal therapy of metastatic breast Ca in postmeno
Chemo combo for advanced bladder CA
Penile CA 0% in men who are ?
male contraceptive = exogenous hormone?
MC site to endometriosis
HTN after 20 wk w/o proteinuria
CA w/ high rate of extra-uterine dz, NO myometrial invasion of tumor
beta 2 receptors cause uterine ?
'powder burn' lesions
Hallmark pathological finding of granulosa cell tumots
malignant germ cell tumor: PLAP, Oct 3/4, cKIT
exogenous testosterone leads to ? type of kidney stones
MC location of transitional cell cancer
Targeted therapy for ER+ breast CA
Colposcopy: cells w/ inc collagen turn white w/ ?
ovarian neoplasm w/ 3 germinal layers
MC site of ectopic pregnant
Call-Exner bodies, Inhibin+
Origin of 90% ovarian cancers (aka MC form)
HTN after 20 wk gestation assoc w/ proteinuria
MC testicular tumor
Dz: epidermis of nipple contains tumor cells
MCC male infertility in the world
MCC UTO in male children
Name: loss of cell polarity, inc N:C, irreg shape, prominent nucleoli
Amniotic Fluid Index >90th %ile
Type of cancer after tx for mediastinal mass in college age woman
hormonal therapy of metastatic breast Ca causing chemical castration
Major SE of contraceptive implants
MCC abnml uterine bleeding in postmenopausal
Appendix testes remnant of ?
Lady on tamoxifen w/ post-menopausal bleeding - next step?
intraabdominal pregnancy, later found in a 60yo woman
MC ovarian germ cell tumor
MCC Epididymal Orchitis in young men
Tx: tubal factor infertility
MC gynecologic CA
Tumor, sx: precocious puberty, hyperandrogenism, pelvic mass/pain
Special type breast CA, high grade but good prognosis
Papillary projections surrounded by Schiller-Duval bodies
Mutation in mucinous ovarian tumors
MC neoplasm in young men
implantation into cornu of uterus or lower uterine segment
Molecular? Type I, simple - complex hyperplasia
% of simple atypical hyperplasia that progressed to cancer
MCC of amenorrhea (after pregnancy)
sudden huge increase in PSA likely due to?
class of Rx for urge incontinence to tighten outlet
Type of incontinence: outlet obstruction
Chromosome 17, 85% lifetime breast Ca risk
intraurethral Rx for ED
MC aneuploidy in abortuses
Renal CA assoc w/ Von Hippel-Lindau
Sperm with DNA damage is assoc w/ ?
Lab value inc if patient is not making sperm
Class of Rx for urge incontinence to dec contractility
Tx of choice for vaginal atrophy
Uterine size discrepant from dates
Kidney CA stage T4, invades
mech of finasteride, dutasteride
MC tumor of myometrium
Bilateral ovarian mets w/ signet ring
Converts androgens to estrogen
Worst SE of Magnesium sulfate
malignant germ cell tumor: AFP
breast path - clown face
Ovarian tumor w/ KRAS and BRAF mutations
BPH Rx SE: orthostasis, dizziness, fall risk
amenorrhea w/ high serum androgens, nl estrogen, low progesterone
% of simple hyperplasia that progressed to cancer
Tx symptomatic bone mets (prostate CA)
Stage: detected from elevated PSA alone, normal DRE & TRUS
Why is stage I breast Ca 10-year survival only 75%?
MC ovarian tumor (and cancer)
measure seminal vesciles - dilated due to?
MC gynecological CA worldwide
Tx PUV: Incise valve to damage leaflet
trophoblastic proliferation, cystic villi, no fetal tissue
postmenopausal, complex hyperplasia w/ atypia - tx?
monoclonal ab to HER-2 neu
Main mode of spread of ovarian cancer
MC trisomy in spontaneous abortion
If surgery unavailable for testicular torson, reduce by twisting?
Infection causing bladder CA
normal strict morphology required to bind to?
Zone sampled in pap smear and biopsy
Tumor from dense fibroconnective tissue of the breast
How to stage endometrial CA
Malignant tumor of admixed proliferating trophoblasts, no villi
MC site of involvement in endometriosis
Bladder cancer sx in 85% of cases
presence of endometrial glands in uterine myometrium
Other name for ovarian fibroma
antepartum hemorrhage after 20 wks
e of incontinence: unstable bladder
abnormal dev of chorionic villi in pregnancy can become?
screening for nonpalpable breast masses
Breast duct/lobule cells that produce milk
lobular (breast) carcinoma in situ is assoc w/ invasive cancer where ?

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