| Position held | Woman |
| Third woman to serve on the Supreme Court | |
| First woman to serve in her state House, State Senate, the House of Representatives, and the Senate | |
| First woman to be named as a running mate for a major party | |
| First woman to win a state in a primary for a major party | |
| First woman to serve in a Cabinet | |
| First woman to sevre as Secretary of State | |
| First woman to be named as a running mate for the Republican Party | |
| First openly lesbian elected to Congress | |
| First first lady (not Hillary Clinton) elected to Congress | |
| First African American woman elected to the Senate | |
| First woman to defeat an incumbent Governor | |
| Secretary of Labor under George W. Bush, wife of Senate Minority leader Mitch McConnell | |