Science / Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Lowers pyrimidine nucleotide levels
Expresses NK inhibitor factor and blocks killing by NK cells
Inhibits purine synthesis
Immunosuppressant that inhibits T-independent B cell activation
Capsular polysaccharide inhibits phagocytosis
Anti-TNF with chimeric receptor
Microbe that crosses the placenta and can cause meningitis in newborns
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
SAP protein in XLP cannot bind this molecule
Mouse mAb
Chimeric anti-TNF monoclonal antibody
Tx of acrolein toxicity
Synthesizes modified LPS that resists peptide antibiotics
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Expresses sialic acid which inhibits C3 and C5 convertases
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Inhibits cyclosporine by binding FKBP
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Inhibits mTOR and prevents T cells from making proteins for proliferation
Microbe that moves from cell to cell without going extracellular
Monoclonal antibody indicated for B lymphomas
Inhibits DHFR, lowers purine levels
Anti-CD20 chimeric monoclonal antibody
Humanized mAb
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Tx of methotrexate toxicity
Chimeric mAb
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
M protein blocks C3 binding to organism and C3b binding to complement receptors
Fully human monoclonal antibody against TNF
Human antibody
Inhibits IMP dehydrogenase, lowers dGTP levels
Inhibits IL-10 synthesis, good for tx EBV
Microbe that inhibits phagolysosome fusion
Virus that inhibits antigen presentation by interfering with TAP transporter
Produces catalase, resisting ROS in phagocytes

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