Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Synthesizes modified LPS that resists peptide antibiotics
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Immunosuppressant that inhibits T-independent B cell activation
Microbe that inhibits phagolysosome fusion
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Lowers pyrimidine nucleotide levels
Expresses sialic acid which inhibits C3 and C5 convertases
Tx of methotrexate toxicity
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Mouse mAb
Microbe that moves from cell to cell without going extracellular
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Microbe that crosses the placenta and can cause meningitis in newborns
SAP protein in XLP cannot bind this molecule
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Inhibits DHFR, lowers purine levels
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Anti-TNF with chimeric receptor
HintAnswerExtra
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Inhibits IMP dehydrogenase, lowers dGTP levels
Capsular polysaccharide inhibits phagocytosis
Inhibits purine synthesis
Humanized mAb
M protein blocks C3 binding to organism and C3b binding to complement receptors
Chimeric mAb
Anti-CD20 chimeric monoclonal antibody
Tx of acrolein toxicity
Chimeric anti-TNF monoclonal antibody
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Human antibody
Monoclonal antibody indicated for B lymphomas
Virus that inhibits antigen presentation by interfering with TAP transporter
Inhibits mTOR and prevents T cells from making proteins for proliferation
Produces catalase, resisting ROS in phagocytes
Inhibits cyclosporine by binding FKBP
Expresses NK inhibitor factor and blocks killing by NK cells
Fully human monoclonal antibody against TNF
Inhibits IL-10 synthesis, good for tx EBV
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation

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