Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Inhibits IMP dehydrogenase, lowers dGTP levels
Inhibits DHFR, lowers purine levels
Lowers pyrimidine nucleotide levels
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Human antibody
Fully human monoclonal antibody against TNF
Microbe that crosses the placenta and can cause meningitis in newborns
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Tx of acrolein toxicity
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Inhibits IL-10 synthesis, good for tx EBV
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Produces catalase, resisting ROS in phagocytes
Immunosuppressant that inhibits T-independent B cell activation
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Capsular polysaccharide inhibits phagocytosis
SAP protein in XLP cannot bind this molecule
Chimeric anti-TNF monoclonal antibody
Expresses sialic acid which inhibits C3 and C5 convertases
Monoclonal antibody indicated for B lymphomas
Mouse mAb
Lose depot and stranger signals/adjuvant effect in this type of vaccine
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Inhibits cyclosporine by binding FKBP
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Anti-TNF with chimeric receptor
Expresses NK inhibitor factor and blocks killing by NK cells
Anti-CD20 chimeric monoclonal antibody
Inhibits mTOR and prevents T cells from making proteins for proliferation
Microbe that moves from cell to cell without going extracellular
Virus that inhibits antigen presentation by interfering with TAP transporter
Microbe that inhibits phagolysosome fusion
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Inhibits purine synthesis
M protein blocks C3 binding to organism and C3b binding to complement receptors
Humanized mAb
Synthesizes modified LPS that resists peptide antibiotics
Tx of methotrexate toxicity
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Chimeric mAb
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG

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