Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Human antibody
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Chimeric mAb
Microbe that inhibits phagolysosome fusion
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Mouse mAb
Produces catalase, resisting ROS in phagocytes
Expresses sialic acid which inhibits C3 and C5 convertases
Monoclonal antibody indicated for B lymphomas
Synthesizes modified LPS that resists peptide antibiotics
Chimeric anti-TNF monoclonal antibody
Capsular polysaccharide inhibits phagocytosis
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Inhibits IL-10 synthesis, good for tx EBV
Fully human monoclonal antibody against TNF
Microbe that moves from cell to cell without going extracellular
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Immunosuppressant that inhibits T-independent B cell activation
Inhibits mTOR and prevents T cells from making proteins for proliferation
Anti-CD20 chimeric monoclonal antibody
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
HintAnswerExtra
Expresses NK inhibitor factor and blocks killing by NK cells
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Inhibits cyclosporine by binding FKBP
Inhibits IMP dehydrogenase, lowers dGTP levels
Tx of acrolein toxicity
Lose depot and stranger signals/adjuvant effect in this type of vaccine
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
Inhibits DHFR, lowers purine levels
Anti-TNF with chimeric receptor
Microbe that crosses the placenta and can cause meningitis in newborns
Humanized mAb
Lowers pyrimidine nucleotide levels
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Inhibits purine synthesis
M protein blocks C3 binding to organism and C3b binding to complement receptors
SAP protein in XLP cannot bind this molecule
Virus that inhibits antigen presentation by interfering with TAP transporter
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Tx of methotrexate toxicity

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