Vaccine, virus, bacteria, or immunosuppressant? Quiz by hilaryh

Hint	Answer	Extra
Mouse mAb		0
Inhibits purine synthesis		0
Inhibits DHFR, lowers purine levels		0
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER		0
Microbe that inhibits phagolysosome fusion		Survives within the phagosome
Chimeric anti-TNF monoclonal antibody		0
Immunosuppressant that inhibits T-independent B cell activation
Lose depot and stranger signals/adjuvant effect in this type of vaccine		0
Anti-TNF with chimeric receptor
Anti-CD20 chimeric monoclonal antibody		0
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin		0
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG		0
Inhibits IL-10 synthesis, good for tx EBV		0
Microbe that moves from cell to cell without going extracellular
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa		0
Monoclonal antibody indicated for B lymphomas		0
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Capsular polysaccharide inhibits phagocytosis		0
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?		0
Lowers pyrimidine nucleotide levels		Inhibits dihydroorate dehydrogenase
SAP protein in XLP cannot bind this molecule
Tx of methotrexate toxicity		Folinic acid

Hint	Answer	Extra
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Virus that inhibits antigen presentation by interfering with TAP transporter		0
Inhibits mTOR and prevents T cells from making proteins for proliferation
Fully human monoclonal antibody against TNF		0
Tx of acrolein toxicity		0
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death		0
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage		0
Expresses NK inhibitor factor and blocks killing by NK cells		0
Inhibits cyclosporine by binding FKBP		0
Expresses sialic acid which inhibits C3 and C5 convertases		0
Produces catalase, resisting ROS in phagocytes		0
Human antibody
Chimeric mAb		0
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells		0
Inhibits IMP dehydrogenase, lowers dGTP levels		0
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances		0
Humanized mAb		Humanized in the V region
Synthesizes modified LPS that resists peptide antibiotics		0
M protein blocks C3 binding to organism and C3b binding to complement receptors		0
Microbe that crosses the placenta and can cause meningitis in newborns

Javascript is not currently enabled on your browser.
If you do have Javascript enabled:
This site uses javascript to make the magic happen.
Please turn on javascript and reload this page, or use a more current browser (like Firefox)