Immunology Vaccines, Microbes, Immunosuppressants

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Can you name the vaccine, virus, bacteria, or immunosuppressant??

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Human antibody
X-linked proliferative syndrome results in EBV and lymphomas due to lack of this signaling protein
Fusion protein on macrophages upregulated in mycobacterial infection that cuases formation of giant cells
Flu vaccine that should not be given to children under the age of 8 except in certain circumstances
Immunosuppressant that inhibits T-independent B cell activation
Lose depot and stranger signals/adjuvant effect in this type of vaccine
When producing monoclonal antibodies, the fusion partner is a tumor B cell lacking what enzyme?
Recombinant fully human TNF-a receptor mAb that has ligand-binding portion fused to IgG
Inhibits calcineurin and prevents NFAT migration to the nucleus by binding cyclophilin
Virus that inhibits antigen presentation by interfering with TAP transporter
Inhibits DHFR, lowers purine levels
Fungus that escapes phagolysosomes and resides in the cytoplasm of a macrophage
SAP protein in XLP cannot bind this molecule
Virus that inhibits proteasomal activity, produces IL-10, inhibits macrophage and DC activation
Inhibits IL-10 synthesis, good for tx EBV
Mouse mAb
Anti-TNF with chimeric receptor
Lowers pyrimidine nucleotide levels
Synthesizes modified LPS that resists peptide antibiotics
Virus that blocks effector cell activation and produces soluble IL-1 or IFN-y receptors
Anti-CD20 chimeric monoclonal antibody
Fully human monoclonal antibody against TNF
HintAnswerExtra
Produces catalase, resisting ROS in phagocytes
M protein blocks C3 binding to organism and C3b binding to complement receptors
Tx of methotrexate toxicity
Inhibits cyclosporine by binding FKBP
Expresses sialic acid which inhibits C3 and C5 convertases
Virus that inhibits proteasomal activity and removes class I MHC molecules from the ER
Expresses NK inhibitor factor and blocks killing by NK cells
Tx of acrolein toxicity
Chimeric mAb
Metabolite of cyclophosphamide that has a toxicity damaging bladder mucosa
Inhibits mTOR and prevents T cells from making proteins for proliferation
Microbe that moves from cell to cell without going extracellular
Inhibits purine synthesis
Microbe that crosses the placenta and can cause meningitis in newborns
Humanized mAb
Inhibits IMP dehydrogenase, lowers dGTP levels
Chimeric anti-TNF monoclonal antibody
Monoclonal antibody indicated for B lymphomas
Alkylating agent that crosslinks DNA-DNA and DNA-protein, blocking DNA replication and inducing cell death
Capsular polysaccharide inhibits phagocytosis
Microbe that inhibits phagolysosome fusion

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Created Feb 12, 2013ReportNominate
Tags:Nintendo, extra, immunology, microbe, virus