| Hint | Answer |
| Izzie jeopardized Denny's life by cutting this | |
| Ava's real name | |
| The hospital Seattle Grace merges with | |
| Burke won this award after leaving Seattle Grace | |
| Two men killed Derek's father because they wanted this object | |
| Ellis Grey suffered from this disease before she died | |
| Sadie's nickname for Meredith | |
| Thatcher's wife and Lexie's mother's name | |
| The surgeon who operates on George's father | |
| Where Cristina went for medical school | |
| Seattle Grace's ranking goes down to this number | |
| | Hint | Answer |
| Finn's profession | |
| Addison eventually moves to this city (where the show 'Private Practice is set) | |
| Derek had a brief relationship with this nurse | |
| This constantly-perky surgeon was in the running for chief resident, and substituted for Bailey when she was on maternity leave | |
| Callie's full first name | |
| Bailey's son's nickname | |
| This resident had an abusive father and went through 17 foster care families | |
| The nurses in the surgery department boycotted this attending for a day | |
| This female attending supported George's decision to join the army, much to Callie's dismay | |
| The name of Richard's and Adele's niece, who gets a prom in the hospital | |
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