| Character | Guest Star | Occupation |
| Lord John Marbury | |
| Joey Lucas | |
| Father Thomas Cavanaugh | |
| Ted Marcus | |
| Special Agent Gina Toscano | |
| Lionel Tribbey | |
| Dr. Stanley Keyworth | |
| Roberto Mendoza | |
| Ann Stark | |
| Mark Gottfried | |
| Dr. Millicent Griffith | |
| Oliver Babish | |
| General Alan Adamley | |
| Albie Duncan | |
| Jordon Kendall | |
| | Character | Guest Star | Occupation |
| Dr. Dalton Millgate | |
| Tabatha Fortis | |
| Special Agent Simon Donovan | |
| Jake Kimball | |
| Lt. Commander Jack Reese | |
| Joe Quimby | |
| Special Agent Wesley Davis | |
| Lewis Berryhill | |
| D.W. Newman | |
| Meeshell Anders | |
| Evelyn Baker Lang | |
| Eric Baker | |
| Lawrence Lessig | |
| Senator Rafe Framingham | |
| Louise 'Lou' Thornton | |
|