| Cities | City that Doesn't Belong | Interstate |
| Los Angeles, San Francisco, Sacramento, Portland? | |
| Charleston (SC), Richmond, Newark, New Haven? | |
| Cheyenne, Des Moines, Gary, Pittsburgh? | |
| Phoenix, San Antonio, Austin, Houston? | |
| Butte, Billings, Beloit, Buffalo (NY)? | |
| Jackson, Little Rock, St. Louis, Chicago? | |
| Kansas City, Indianapolis, Dayton, Philadelphia? | |
| Dallas, Oklahoma City, Omaha, Minneapolis? | |
| Fort Worth, Shreveport, Montgomery, Atlanta? | |
| Birmingham, Charlotte, Greensboro, Durham? | |
| Flagstaff, Albuquerque, Amarillo, Tulsa? | |
| | Cities | City that Doesn't Belong | Interstate |
| Boise, Pocatello, Salt Lake City, Las Vegas? | |
| Fargo, Madison, Milwaukee, East Lansing? | |
| Columbia (SC), Charleston (WV), Cincinnati, Cleveland? | |
| Evansville, Lexington (KY), Huntington, Norfolk? | |
| Janesville, Rockford, Peoria, Bloomington? | |
| Cape Girardeau, Paducah, Nashville, Chattanooga? | |
| Grand Forks, Sioux Falls, Sioux City, Wichita? | |
| Denver, Lincoln, Harrisburg, Camden? | |
| Hartford, Springfield (MA), Burlington, St Johnsbury? | |
| BONUS QUESTION: What do all these cities off these roads have in common?? | |
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