| Question | Answer |
| What year did Seward become a Republican? | |
| In which year did Seward run for the Republican nomination for the presidency? | |
| Who else ran against him for the nomination | |
| Who won the nomination? | |
| Which cabinet position would Seward receive in 1860? | |
| Where in Washington, DC was Seward's home located | |
| What was the date of the assassination attempt on Seward's life? | |
| Who attempted the assassination? | |
| Who succeeded Abraham Lincoln after he was assassinated? | |
| In what year did the United States purchase 'Russian America' aka Alaska? | |
| How much did the government pay for Alaska | |
| Who was the Czar of Russia during the negotiations? | |
| What was the year that Seward retired from public life? | |
| What did he die from? | |
| What was year of his death? | |
| Who was left the House after his death? | |
| What year did the House open to the general public as a museum? | |
| Name the first President to visit the home? | |
| Name the last President to visit the home? | |