| hint | villain |
| Master of magnetism | |
| Ruler of Latveria | |
| Devourer of worlds | |
| Trickster God | |
| Posessed Jean Grey | |
| Wilson Fisk | |
| Norman Osborn | |
| Archenemy of Captain America | |
| Mutant shapeshifter | |
| Cain Marko | |
| aka Benjamin Poindexter | |
| Alien symbiote | |
| Evil robot | |
| First mutant ever | |
| Tentacled scientist | |
| Nathaniel Essex | |
| Posesses the Moonstones | |
| The mad titan | |
| aka Satan | |
| Dark shadow of Professor X | |
| Half-brother of the Chameleon | |
| | hint | villain |
| Hulk wannabe | |
| Leader of the Hellfire Club | |
| Adversary of Dr Strange | |
| Fashionable Spider-Man foe | |
| dr Curt Connors | |
| Green genius | |
| Timetraveler from the 30th century | |
| Televangelist | |
| United States General | |
| aka Flint Marko | |
| also known as Mutant X | |
| Yuriko Oyama | |
| Powered by ten rings | |
| Master of illusions | |
| Maxwell Dillon | |
| Another alien symbiote | |
| Lord of the Negative Zone | |
| Soviet soldier with tentacles | |
| Power to generate complex telepathic illusions | |
| Chinese dragon | |
| Leader of AIM | |
|