Anti HIV agents

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Can you name the Anti HIV drugs?

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Descriptionagentclass
Adverse reaction: peripheral neuropathyNRTI
Adverse reactions: hypersensitivity, increased risk of CVDNRTI
Blocks CCR5 co-receptorEntry inhibitor
Co-administration with TMP-SMZ increases bioavailabilityNRTI
Adverse reaction: nephrolithiasis, patient must be adequately hydratedPI
Prevents vertical transmission, adverse reactions: myelosuppression, gi intolerance, hematologic toxicity when given with ganciclovir or ribavirinNRTI
binds to and inhibits gp41 of HIVFusion inhibitor
Contraindicated in children, adverse reactions: hypersensitivity of palmsNRTI
Inhibits and induces cyp3A4; adverse reactions: CNS toxicity, Gi intolerance, skin rashNNRTI
Adverse reactions: GI discomfort, rhinitis. Given once dailyPI
Descriptionagentclass
Adverse reactions: jaundice, increased QT intervalPI
Most potent cyp3A4 inhibitor of the protease inhibitors. Used to prolong half life of other PIsPI
Can cause severe, potentially fatal hepatotoxicityNNRTI
Contraindicated in patients with allergies to sulfanomidesPI
Given to pregnant womenPI
NucleoTIDE analogueNRTI
Avoid in patients with PKU, adverse reactions: pancreatitis, retinal changesNRTI
Blocks DNA strand transfer from viral to host genomeIntegrase inhibitor
Adverse reaction: skin rash; drug interactions: inhibits cyp3A4 and cyp2C9NNRTI

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