| Description | agent | class |
| Adverse reactions: hypersensitivity, increased risk of CVD | |
| Co-administration with TMP-SMZ increases bioavailability | |
| Contraindicated in children, adverse reactions: hypersensitivity of palms | |
| Inhibits and induces cyp3A4; adverse reactions: CNS toxicity, Gi intolerance, skin rash | |
| Adverse reaction: peripheral neuropathy | |
| Blocks CCR5 co-receptor | |
| Avoid in patients with PKU, adverse reactions: pancreatitis, retinal changes | |
| Most potent cyp3A4 inhibitor of the protease inhibitors. Used to prolong half life of other PIs | |
| binds to and inhibits gp41 of HIV | |
| Blocks DNA strand transfer from viral to host genome | |
| | Description | agent | class |
| Contraindicated in patients with allergies to sulfanomides | |
| NucleoTIDE analogue | |
| Given to pregnant women | |
| Prevents vertical transmission, adverse reactions: myelosuppression, gi intolerance, hematologic toxicity when given with ganciclovir or ribavirin | |
| Adverse reactions: jaundice, increased QT interval | |
| Adverse reactions: GI discomfort, rhinitis. Given once daily | |
| Can cause severe, potentially fatal hepatotoxicity | |
| Adverse reaction: skin rash; drug interactions: inhibits cyp3A4 and cyp2C9 | |
| Adverse reaction: nephrolithiasis, patient must be adequately hydrated | |
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