Science / Anti HIV agents

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Can you name the Anti HIV drugs?

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Descriptionagentclass
Blocks DNA strand transfer from viral to host genomeIntegrase inhibitor
NucleoTIDE analogueNRTI
Given to pregnant womenPI
Contraindicated in children, adverse reactions: hypersensitivity of palmsNRTI
binds to and inhibits gp41 of HIVFusion inhibitor
Contraindicated in patients with allergies to sulfanomidesPI
Most potent cyp3A4 inhibitor of the protease inhibitors. Used to prolong half life of other PIsPI
Adverse reaction: peripheral neuropathyNRTI
Adverse reactions: hypersensitivity, increased risk of CVDNRTI
Inhibits and induces cyp3A4; adverse reactions: CNS toxicity, Gi intolerance, skin rashNNRTI
Descriptionagentclass
Can cause severe, potentially fatal hepatotoxicityNNRTI
Co-administration with TMP-SMZ increases bioavailabilityNRTI
Prevents vertical transmission, adverse reactions: myelosuppression, gi intolerance, hematologic toxicity when given with ganciclovir or ribavirinNRTI
Blocks CCR5 co-receptorEntry inhibitor
Avoid in patients with PKU, adverse reactions: pancreatitis, retinal changesNRTI
Adverse reactions: jaundice, increased QT intervalPI
Adverse reaction: skin rash; drug interactions: inhibits cyp3A4 and cyp2C9NNRTI
Adverse reaction: nephrolithiasis, patient must be adequately hydratedPI
Adverse reactions: GI discomfort, rhinitis. Given once dailyPI

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