| Actor & Actress Playing Husband & Wife | TV Sitcom | Character Names |
| Kevin James & Leah Remini | |
| Brad Garrett & Joely Fisher | |
| Robert Young & Jane Wyatt | |
| James Avery & Janet Hubert | |
| Carroll O'Connor & Carol Burnett | |
| Patrick Duffy & Suzanne Somers | |
| George Lopez & Constance Marie | |
| Damon Wayans & Tisha Campbell-Martin | |
| James Sikking & Belinda Montgomery | |
| Max Wright & Anne Schedeen | |
| John Ritter & Katey Sagal | |
| Earle Hyman & Clarice Taylor | |
| Robert Carradine & Hallie Todd | |
| David Hyde Pierce & Jane Leeves | |
| Woody Harrelson & Jackie Swans | |