| Stars or co-stars | Show | # episodes (years) |
| Arlene Francis, Dorothy Kilgallen (gnt) | |
| Kitty Carlisle, Tom Poston (gnt) | |
| Gene Rayburn, various (gnt) | |
| Edgar Buchanan, Linda Henning | |
| David Hartman, Rosemary Murphy | |
| Harvey Korman, Lyle Waggoner | |
| Allen Ludden, various (gnt) | |
| Gavin MacLeod, Fred Grandy | |
| Tony Randall, Swoosie Kurtz | |
| Dick Clark, various (gnt) | |
| Debbie Allen, Gene Anthony Ray | |
| Vicki Lawrence, Ken Berry | |
| James Brolin, Connie Sellecca | |
| Ed Begley Jr., Denzel Washington | |
| Tony Danza, Judith Light | |
| Andy Griffith, Nancy Stafford | |
| Richard Mulligan, Dinah Manoff | |
| Dick Van Dyke, Victoria Rowell | |
| Brooke Shields, Kathy Griffin | |
| A Martinez, Robin Wright (sop) | |
| Calista Flockhart, Portia de Rossi | |
| Mike Judge, Kathy Najimy (ani) | |
| | Stars or co-stars | Show | # episodes (years) |
| Lacey Chabert, Tim Curry (ani) | |
| Dan Castellaneta, Julie Kavner (ani) | |
| Anthony Clark, Jean Louisa Kelly | |
| Melina Kanakaredes, Mike Farrell | |
| Mila Kunis, Ashton Kutcher | |
| Treat Williams, Gregory Smith | |
| Dylan McDermott, Camryn Manheim | |
| Damon Wayans, Tisha Campbell-Martin | |
| Bryan Cranston, Frankie Muniz | |
| Matt LeBlanc, Drea de Matteo | |
| James Spader, William Shatner | |
| Susan Flannery, Jack Wagner (sop) | |
| America Ferrera, Vanessa Williams | |
| Mark Steines, Mary Hart (gnt) | |
| Barbara Walters, Joy Behar (gnt) | |
| Tina Fey, Alec Baldwin | |
| Jason Lee, Jaime Pressly | |
| Darrell Hammond, Seth Meyers | |
| James Lipton, various (gnt) | |
| Patricia Heaton, Neil Flynn | |
| Kristen Bell, Jamie Lee Curtis | |
| Joel McHale, Chevy Chase | |
|