| Description | Neighborhood |
| Original home of the New York (baseball) Giants; now home to the Apollo Theater | |
| Unless you have a key, the park in this neighborhood is only open to you one day each year | |
| From Central Park to Riverside Park | |
| North of Little Italy | |
| Destination for many immigrants; home to Tenement Museum | |
| Only neighborhood on this list named after a building | |
| The original wall enclosing the first Dutch Settlement ran through this neighborhood | |
| Home to 10021 and 10022, NYC's two richest zip codes | |
| Skyscrapers, Broadway, Rockefeller Center, and lots of tourists | |
| Canal Street is its main drag | |
| | Description | Neighborhood |
| Home to Columbia University | |
| Largely Dominican neighborhood popularized in a recent Broadway musical | |
| Known as 'el barrio' | |
| Bohemian capital | |
| Home of Jay-Z, 'right next to DeNiro' | |
| Gets its name from its devilish reputation prior to gentrifying in the 1990s | |
| Northern tip of the island | |
| Originally part of the Hudson River; most buildings completed in the 1980s and 1990s | |
| Center of gay nightlife and home to many trendy clubs | |
| South of Houston Street | |
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