| Topic Description | Answer |
| First Major Soda/Pop Company in the US | |
| First People to Fly and Patent a Type of Plane | |
| First African American President | |
| America's/World's First Penitentiary (Now Closed) | |
| The First NBA Team to Win a Game (Still Around Today) | |
| First American Chain Store | |
| City Home to US First Bank, 'First Bank of the United States' | |
| First English Settlement in America(On US Land) | |
| First US State to Abolish Slavery | |
| Number of Stars on the First US Flag | |