Receptors and Cell Signalling and The Thyroid Gland

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Can you name the Receptors and Cell Signalling?

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True or False: The thyroid hormones are made within the thyroid epithelial cells.
When there is an iodine deficiency, the percentage of T3 made increases or decreases?
What percentage of the ingested iodine actually makes it to the thyroid?
enzyme responsible for the liberation of iodine and the iodination of tyrosine to produce the thyroid hormones
patients with graves disease have a higher or lower plasma TSH level?
Which thyroid hormone is responsible for the negative feedback regulation of TRH and TSH?
a system of chemical messengers that are released into the interstitial fluid to act on adjacent cells is known as _____
protein/ peptide hormones are released from cells via (diffusion or exocytosis?)
The thyroid hormones are released into circulation via what process?
One possible cause of this disorder can be the binding of autoantibodies to the TSH receptor preventing the release of thyroid hormones.
True or False: Protein or peptide hormones have a short half-life
True or False: The thyroid hormones pre-dominantly travel in the blood in free form.
chemical messengers that are transported by the blood to act on target organs and cells.
this disorder occurs due to a defective V2 receptor in the kidney that causes an inability to retain water.
True or False: Metabolism and Feedback Regulation are key in control of the endocrine system.
TRH is made in the ______ and the _____ nuclei of the hypothalamus.
an increase in basal metabolic rate is known as ______. It is regulated by Thyroid hormones.
True or False: T3 promotes the storage of energy.
lipid soluble hormones generally bind to what types of receptors?
intracellular receptors for glucocorticoid and mineralcorticoid are primarily located where within a cell?
10% of circulatory T3 and T4 is bound to what protein?
20% of circulatory T3 and T4 is bound to what protein?
this disorder occurs when the G alpha stimulatory subunt of the PTH receptor is defective and causes the patient to have hypocalcemia.
steroid hormones are released from cells via (diffusion or exocytosis?)
When there is an iodine deficiency, the percentage of T4 made increases or decreases?
a system of chemical messengers that are released into the interstitial fluid to act on itself is known as _____
this receptor type opens as a channel in response to ligand binding
thyroid hormone are formed by adding what molecule to tyrosine?
QuestionAnswer
hormone that arise form axon terminal instead of endocrine cells are known as _____.
Where is TSH made? (Be specific)
abnormal disorder of the thyroid that is characterized by decreased appetite, weight gain, cold intolerance, and decreased sweating
hyperthyroidism cause by the binding of an autoantibody to the TSH receptor.
intracellular receptors for estrogen and progesterone are primarily located where within a cell?
found in the apical membrane of the follicular cells and is responsible for transporting iodine from the follicular cells into the lumen of the thyroid follicle.
True or False: During times of starvation, the biologically inactive r-T3 is produced to conserve energy stores.
The release of TSH is stimulated by what?
This hormone acts to increase iodine uptake via NIS, activates thyroid peroxidase, increases the production of thyroglobulin, and increases the secretion of T3 and T4.
intracellular receptors for thyroid hormones are primarily bound to what?
which tyrosine derived group of hormones act similar to steroid hormones
what molecule is bound to a G protein in its inactive form?
When there is an iodine deficiency, the total amount of thyroid hormone produced increases or decreases?
abnormal disorder of the thyroid that is characterized by increased appetite, weight loss, heat intolerance, and increased sweating.
catalyzes the conversion of T4 to T3
water soluble hormones generally bind to receptors that are located where?
what transporter is responsible for actively moving iodine into the thyroid gland?
the addition of two iodine to tyrosine results in what molecule?
which tyrosine derived group of hormones act similar to protein/ peptide hormones
the addition of one iodine to tyrosine results in what molecule?
patients with iodine deficiency have a higher or lower plasma TSH level?
In order to maintain, normal thyroid function we must ingest how much iodine per week (in mg)?
True or False: The half life of T3 is longer than T4.
True or False: The thyroid hormone binding proteins serve to protect T3 and T4 from metabolism and excretion. They also allow for large pools of readily available hormone in the bl
Calcitonin can be found in the _______ cells of the thyroid.
The thyroid gland synthesizes T4 ___% of the time.
70% of circulatory T3 and T4 is bound to what protein?

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