Plasma Glucose Regulation

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these cells of the pancreas make somatostatin
What other 2 molecules can be found in mature insulin granules besides insulin?
insulin independent transporter
acetylcholine acts to _____ insulin secretion
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
The B subunit of the insulin receptor acts to bind and recognize insulin.
Major targets of insulin include liver, _____ and _____
T/F: Hepatocytes contain GLUT4 transporters.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
T/F: C peptide has no biological funtion.
insulin deficiency causes a (an) _____ in plasma glucose
percentage of alpha cells in the pancreas
insulin independent diabetes
In liver, glucose stimulates which enzyme?
these cells of the pancreas make insulin
production of glucose from non-carbohydrate sources
T/F: Proinsulin is composed of 2 subunits.
Blood glucose levels must be maintained at ___mg/ 100ml.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
These drugs act on the ATP dependent K channel to activate insulin secretion
percentage of delta cells in the pancreas
percentage of beta cells in the pancreas
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
insulin dependent diabetes
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
used as a measure of insulin secretion
insulin dependent transporter
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
low levels of glucose stimulates the release of _____.
Normal blood glucose levels are ___mg/ dl
persistent hyperglycemia causes perisistent _______.
T/F: Glucose enters the cell via active transport.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
these cells of the pancreas make glucagon
Dr. Benting won the nobel prize for insulin in ____.
Muscle and adipocytes contain GLUT4.
T/F: 98% of the pancreas has endocrine function.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
How much oral glucose is administered during a glucose tolerance test? (grams)
The liver degrades ___% of the insulin released.
GI hormones that are released in response to a meal containing glucose
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.

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Created Feb 27, 2012ReportNominate
Tags:concept, regulation