Plasma Glucose Regulation

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T/F: 98% of the pancreas has endocrine function.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
The liver degrades ___% of the insulin released.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
these cells of the pancreas make insulin
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
These drugs act on the ATP dependent K channel to activate insulin secretion
T/F: Glucose enters the cell via active transport.
persistent hyperglycemia causes perisistent _______.
Normal blood glucose levels are ___mg/ dl
low levels of glucose stimulates the release of _____.
percentage of beta cells in the pancreas
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
T/F: Hepatocytes contain GLUT4 transporters.
these cells of the pancreas make somatostatin
In liver, glucose stimulates which enzyme?
these cells of the pancreas make glucagon
GI hormones that are released in response to a meal containing glucose
Major targets of insulin include liver, _____ and _____
acetylcholine acts to _____ insulin secretion
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
insulin dependent transporter
QuestionAnswer
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
How much oral glucose is administered during a glucose tolerance test? (grams)
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
T/F: Proinsulin is composed of 2 subunits.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
production of glucose from non-carbohydrate sources
insulin deficiency causes a (an) _____ in plasma glucose
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
T/F: C peptide has no biological funtion.
insulin dependent diabetes
insulin independent diabetes
percentage of alpha cells in the pancreas
percentage of delta cells in the pancreas
The B subunit of the insulin receptor acts to bind and recognize insulin.
What other 2 molecules can be found in mature insulin granules besides insulin?
insulin independent transporter
Dr. Benting won the nobel prize for insulin in ____.
used as a measure of insulin secretion
Blood glucose levels must be maintained at ___mg/ 100ml.
Muscle and adipocytes contain GLUT4.
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.

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