Science / Plasma Glucose Regulation

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Can you name the HYTQ concepts?

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used as a measure of insulin secretion
low levels of glucose stimulates the release of _____.
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
These drugs act on the ATP dependent K channel to activate insulin secretion
T/F: Proinsulin is composed of 2 subunits.
acetylcholine acts to _____ insulin secretion
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
Major targets of insulin include liver, _____ and _____
these cells of the pancreas make insulin
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
In liver, glucose stimulates which enzyme?
T/F: Hepatocytes contain GLUT4 transporters.
percentage of alpha cells in the pancreas
percentage of delta cells in the pancreas
these cells of the pancreas make glucagon
Dr. Benting won the nobel prize for insulin in ____.
The B subunit of the insulin receptor acts to bind and recognize insulin.
How much oral glucose is administered during a glucose tolerance test? (grams)
persistent hyperglycemia causes perisistent _______.
The liver degrades ___% of the insulin released.
insulin independent diabetes
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
T/F: Glucose enters the cell via active transport.
insulin deficiency causes a (an) _____ in plasma glucose
T/F: 98% of the pancreas has endocrine function.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: C peptide has no biological funtion.
insulin dependent transporter
Normal blood glucose levels are ___mg/ dl
percentage of beta cells in the pancreas
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
these cells of the pancreas make somatostatin
insulin independent transporter
production of glucose from non-carbohydrate sources
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
Blood glucose levels must be maintained at ___mg/ 100ml.
Muscle and adipocytes contain GLUT4.
GI hormones that are released in response to a meal containing glucose
insulin dependent diabetes
What other 2 molecules can be found in mature insulin granules besides insulin?

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