Plasma Glucose Regulation

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T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
GI hormones that are released in response to a meal containing glucose
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
percentage of delta cells in the pancreas
These drugs act on the ATP dependent K channel to activate insulin secretion
insulin independent diabetes
Dr. Benting won the nobel prize for insulin in ____.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
T/F: 98% of the pancreas has endocrine function.
percentage of beta cells in the pancreas
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
production of glucose from non-carbohydrate sources
T/F: Glucose enters the cell via active transport.
What other 2 molecules can be found in mature insulin granules besides insulin?
insulin deficiency causes a (an) _____ in plasma glucose
Muscle and adipocytes contain GLUT4.
T/F: Proinsulin is composed of 2 subunits.
persistent hyperglycemia causes perisistent _______.
used as a measure of insulin secretion
The B subunit of the insulin receptor acts to bind and recognize insulin.
percentage of alpha cells in the pancreas
insulin independent transporter
these cells of the pancreas make insulin
these cells of the pancreas make glucagon
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
acetylcholine acts to _____ insulin secretion
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
Blood glucose levels must be maintained at ___mg/ 100ml.
low levels of glucose stimulates the release of _____.
T/F: Hepatocytes contain GLUT4 transporters.
these cells of the pancreas make somatostatin
Major targets of insulin include liver, _____ and _____
Normal blood glucose levels are ___mg/ dl
insulin dependent diabetes
T/F: C peptide has no biological funtion.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
The liver degrades ___% of the insulin released.
How much oral glucose is administered during a glucose tolerance test? (grams)
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
In liver, glucose stimulates which enzyme?
insulin dependent transporter

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Created Feb 27, 2012ReportNominate
Tags:concept, regulation