Plasma Glucose Regulation

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T/F: Hepatocytes contain GLUT4 transporters.
used as a measure of insulin secretion
These drugs act on the ATP dependent K channel to activate insulin secretion
these cells of the pancreas make glucagon
production of glucose from non-carbohydrate sources
T/F: 98% of the pancreas has endocrine function.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
T/F: Glucose enters the cell via active transport.
The liver degrades ___% of the insulin released.
insulin deficiency causes a (an) _____ in plasma glucose
T/F: C peptide has no biological funtion.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
low levels of glucose stimulates the release of _____.
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
persistent hyperglycemia causes perisistent _______.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
percentage of delta cells in the pancreas
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
these cells of the pancreas make insulin
Muscle and adipocytes contain GLUT4.
percentage of alpha cells in the pancreas
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
Major targets of insulin include liver, _____ and _____
T/F: Proinsulin is composed of 2 subunits.
Blood glucose levels must be maintained at ___mg/ 100ml.
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
What other 2 molecules can be found in mature insulin granules besides insulin?
acetylcholine acts to _____ insulin secretion
Dr. Benting won the nobel prize for insulin in ____.
How much oral glucose is administered during a glucose tolerance test? (grams)
percentage of beta cells in the pancreas
these cells of the pancreas make somatostatin
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
Normal blood glucose levels are ___mg/ dl
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
In liver, glucose stimulates which enzyme?
insulin independent diabetes
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
insulin dependent diabetes
insulin dependent transporter
The B subunit of the insulin receptor acts to bind and recognize insulin.
GI hormones that are released in response to a meal containing glucose
insulin independent transporter

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Created Feb 27, 2012ReportNominate
Tags:concept, regulation