Plasma Glucose Regulation

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Can you name the HYTQ concepts?

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In liver, glucose stimulates which enzyme?
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
Blood glucose levels must be maintained at ___mg/ 100ml.
percentage of beta cells in the pancreas
How much oral glucose is administered during a glucose tolerance test? (grams)
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
T/F: C peptide has no biological funtion.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
percentage of delta cells in the pancreas
insulin deficiency causes a (an) _____ in plasma glucose
insulin dependent diabetes
The B subunit of the insulin receptor acts to bind and recognize insulin.
What other 2 molecules can be found in mature insulin granules besides insulin?
GI hormones that are released in response to a meal containing glucose
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
Major targets of insulin include liver, _____ and _____
Muscle and adipocytes contain GLUT4.
percentage of alpha cells in the pancreas
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
Dr. Benting won the nobel prize for insulin in ____.
Normal blood glucose levels are ___mg/ dl
used as a measure of insulin secretion
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
The liver degrades ___% of the insulin released.
T/F: Hepatocytes contain GLUT4 transporters.
insulin independent diabetes
these cells of the pancreas make somatostatin
persistent hyperglycemia causes perisistent _______.
low levels of glucose stimulates the release of _____.
insulin independent transporter
production of glucose from non-carbohydrate sources
T/F: Proinsulin is composed of 2 subunits.
T/F: Glucose enters the cell via active transport.
acetylcholine acts to _____ insulin secretion
these cells of the pancreas make glucagon
these cells of the pancreas make insulin
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
T/F: 98% of the pancreas has endocrine function.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
These drugs act on the ATP dependent K channel to activate insulin secretion
insulin dependent transporter

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