Plasma Glucose Regulation

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T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
Dr. Benting won the nobel prize for insulin in ____.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
Normal blood glucose levels are ___mg/ dl
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
Muscle and adipocytes contain GLUT4.
acetylcholine acts to _____ insulin secretion
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
T/F: C peptide has no biological funtion.
these cells of the pancreas make somatostatin
What other 2 molecules can be found in mature insulin granules besides insulin?
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
T/F: Proinsulin is composed of 2 subunits.
used as a measure of insulin secretion
these cells of the pancreas make glucagon
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
How much oral glucose is administered during a glucose tolerance test? (grams)
Major targets of insulin include liver, _____ and _____
insulin dependent transporter
low levels of glucose stimulates the release of _____.
insulin dependent diabetes
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
QuestionAnswer
T/F: Hepatocytes contain GLUT4 transporters.
GI hormones that are released in response to a meal containing glucose
These drugs act on the ATP dependent K channel to activate insulin secretion
The liver degrades ___% of the insulin released.
production of glucose from non-carbohydrate sources
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
percentage of beta cells in the pancreas
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
Blood glucose levels must be maintained at ___mg/ 100ml.
persistent hyperglycemia causes perisistent _______.
insulin deficiency causes a (an) _____ in plasma glucose
T/F: Glucose enters the cell via active transport.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
In liver, glucose stimulates which enzyme?
percentage of delta cells in the pancreas
these cells of the pancreas make insulin
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
insulin independent transporter
insulin independent diabetes
T/F: 98% of the pancreas has endocrine function.
The B subunit of the insulin receptor acts to bind and recognize insulin.
percentage of alpha cells in the pancreas

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