Can you name the HYTQ concepts? by brittneynewby09

Question	Answer
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
percentage of delta cells in the pancreas
percentage of beta cells in the pancreas
Blood glucose levels must be maintained at ___mg/ 100ml.
Major targets of insulin include liver, _____ and _____
T/F: C peptide has no biological funtion.
percentage of alpha cells in the pancreas
The B subunit of the insulin receptor acts to bind and recognize insulin.
In liver, glucose stimulates which enzyme?
T/F: Glucose enters the cell via active transport.
these cells of the pancreas make somatostatin
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
How much oral glucose is administered during a glucose tolerance test? (grams)
Normal blood glucose levels are ___mg/ dl
insulin dependent transporter
persistent hyperglycemia causes perisistent _______.
T/F: 98% of the pancreas has endocrine function.
T/F: Hepatocytes contain GLUT4 transporters.
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
These drugs act on the ATP dependent K channel to activate insulin secretion
insulin deficiency causes a (an) _____ in plasma glucose
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
insulin independent diabetes

Question	Answer
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
Muscle and adipocytes contain GLUT4.
T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
acetylcholine acts to _____ insulin secretion
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
T/F: Proinsulin is composed of 2 subunits.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
Dr. Benting won the nobel prize for insulin in ____.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
low levels of glucose stimulates the release of _____.
insulin independent transporter
these cells of the pancreas make glucagon
used as a measure of insulin secretion
insulin dependent diabetes
What other 2 molecules can be found in mature insulin granules besides insulin?
these cells of the pancreas make insulin
GI hormones that are released in response to a meal containing glucose
The liver degrades ___% of the insulin released.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
production of glucose from non-carbohydrate sources
T/F: Norepinephrine and epinephrine act to inhibit insulin release.

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