Plasma Glucose Regulation

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T/F: Insulin's response to persistent hyperglycemia is characterized by a sharp initial increase in insulin secretion, then a fall and gradual rise in insulin (due to increase in i
T/F: 98% of the pancreas has endocrine function.
Major targets of insulin include liver, _____ and _____
T/F: Chronic hyperinsulinemia causes a downregulation of insulin receptors due to an imbalance of receptor internalization and recycling.
The liver degrades ___% of the insulin released.
T/F: An increase in sympathetic activity, increases production and synthesis of insulin.
T/F: Insulin is protein hormone and is synthesized from pro-insulin.
insulin dependent transporter
Blood glucose levels must be maintained at ___mg/ 100ml.
production of glucose from non-carbohydrate sources
persistent hyperglycemia causes perisistent _______.
T/F: Insulin receptor is a tyrosine kinase receptor thats acts to autophosphorylate itself.
insulin independent transporter
used as a measure of insulin secretion
T/F: Hepatocytes contain GLUT4 transporters.
low levels of glucose stimulates the release of _____.
This protein is important for the activation of glucose transport and it is phophorylated by the B subunit of the insulin receptor.
IRS mediates the translaocation of what glucose transporter to the cellular membrane?
T/F: Glucose enters the cell via active transport.
insulin dependent diabetes
The B subunit of the insulin receptor acts to bind and recognize insulin.
These drugs act on the ATP dependent K channel to activate insulin secretion
T/F: Acute hypoglycemia cause neurological problems, coma, and death because the brain is dependent upon glucose as a source of energy.
QuestionAnswer
How much oral glucose is administered during a glucose tolerance test? (grams)
T/F: Proinsulin is composed of 2 subunits.
these cells of the pancreas make glucagon
percentage of delta cells in the pancreas
insulin independent diabetes
Dr. Benting won the nobel prize for insulin in ____.
T/F: Norepinephrine and epinephrine act to inhibit insulin release.
Normal blood glucose levels are ___mg/ dl
T/F: Influx of glucose in a hepatocyte activates glucokinase which increase ATP levels, activating ATP dependent K channel. This causes a depolarization of the cell causing an incr
Muscle and adipocytes contain GLUT4.
T/F: Basal glucose levels in a diabetic patient are equivalent to non-diabetic patient.
insulin deficiency causes a (an) _____ in plasma glucose
Currently used in the treatment of diabetes and they act by binding to their G-protein coupled receptor to increase intracellular Ca activating insulin release.
percentage of alpha cells in the pancreas
What other 2 molecules can be found in mature insulin granules besides insulin?
percentage of beta cells in the pancreas
In liver, glucose stimulates which enzyme?
acetylcholine acts to _____ insulin secretion
T/F: C peptide has no biological funtion.
GI hormones that are released in response to a meal containing glucose
these cells of the pancreas make insulin
these cells of the pancreas make somatostatin

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