Growth Hormone Physiology

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Can you name the Growth Hormone Physiology?

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this pathological condition is caused by a deficiency of GH or IGF-1 during childhood. Patients are short (but proportional) with no mental retardation.
this condition is caused by excessive GH before adolescence, which causes increased body size and hyperglycemia.
True or False: IGF acts as a negative feedback regulator of GH release. and acts as a positive feedback regulator of somatostatin release.
Which nucleus of the hypothalamus produces Growth Hormone releasing hormone?
Main role of GH on hepatocytes is to induce the formation of ___.
T/F: When GHRH binds to its receptor intracellularly, it increases cAMP levels and causes an influx of calcium and release of secretory vesicles containing GH.
obesity ______ the release of GH
T/F: GH is a protein hormone that has 2 biologically active isoforms
Insulin and IGF-1 receptors are apart of what class of receptors?
The GH receptor at the liver is a unique receptor coupled to the JAK/ STAT pathway which causes production of _____ and its binding protein.
A decrease in blood sugar (hypoglycemia) would ______ the release of GH.
T/F: The chronic release of GH causes an increase in plasma glucose and increase in plasma insulin, leading to hyperglycemia and insulin resistance.
T/F: Levels of GH increase significantly during the day.
IGF-1 travels in the blood bound to which protein?
The GHRH _____ the release of growth hormone.
inhibits the release of GH
Main target organ for growth hormone that causes its long term effect related to growth
T/F: Growth hormone acts to increase glucose uptake.
T/F: Growth hormone acts to increase glucose availability for energy purposes.
Where is somatostatin produced in the hypothalamus?
this condition is caused by excessive GH after adolescence. It does not increase the length of bones but does increase the growth of soft tissues.
fasting _____ the release of GH
T/F: Somatostatin can only be made in the hypothalamus.
T/F: pvGH is produced by the placenta. It binds to hGH receptor and is extremely important for the development of the fetus.
T/F: GH acts on proteins by increasing the amino acid intake, increasing protein synthesis, increasing transcription, and decreasing protein degradation.
T/F: Maximum secretion of GH during life occurs at puberty.
This receptor is a clearance receptor that removes its ligand out of circulation and into the cell to undergo lysosomal degradation?
short stature or form of dwarfism caused by a lack of GH receptors.
glucagon acts to _______ the release of GH.
Growth hormone _____ lipolysis.

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