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Growth Hormone Physiology
Can you name the Growth Hormone Physiology?
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T/F: When GHRH binds to its receptor intracellularly, it increases cAMP levels and causes an influx of calcium and release of secretory vesicles containing GH.
T/F: Growth hormone acts to increase glucose availability for energy purposes.
obesity ______ the release of GH
T/F: GH acts on proteins by increasing the amino acid intake, increasing protein synthesis, increasing transcription, and decreasing protein degradation.
fasting _____ the release of GH
T/F: pvGH is produced by the placenta. It binds to hGH receptor and is extremely important for the development of the fetus.
this condition is caused by excessive GH before adolescence, which causes increased body size and hyperglycemia.
this condition is caused by excessive GH after adolescence. It does not increase the length of bones but does increase the growth of soft tissues.
Growth hormone _____ lipolysis.
The GH receptor at the liver is a unique receptor coupled to the JAK/ STAT pathway which causes production of _____ and its binding protein.
inhibits the release of GH
Insulin and IGF-1 receptors are apart of what class of receptors?
T/F: Somatostatin can only be made in the hypothalamus.
T/F: Levels of GH increase significantly during the day.
Main role of GH on hepatocytes is to induce the formation of ___.
glucagon acts to _______ the release of GH.
this pathological condition is caused by a deficiency of GH or IGF-1 during childhood. Patients are short (but proportional) with no mental retardation.
A decrease in blood sugar (hypoglycemia) would ______ the release of GH.
True or False: IGF acts as a negative feedback regulator of GH release. and acts as a positive feedback regulator of somatostatin release.
Which nucleus of the hypothalamus produces Growth Hormone releasing hormone?
T/F: Growth hormone acts to increase glucose uptake.
The GHRH _____ the release of growth hormone.
T/F: Maximum secretion of GH during life occurs at puberty.
T/F: GH is a protein hormone that has 2 biologically active isoforms
Main target organ for growth hormone that causes its long term effect related to growth
This receptor is a clearance receptor that removes its ligand out of circulation and into the cell to undergo lysosomal degradation?
IGF-1 travels in the blood bound to which protein?
short stature or form of dwarfism caused by a lack of GH receptors.
Where is somatostatin produced in the hypothalamus?
T/F: The chronic release of GH causes an increase in plasma glucose and increase in plasma insulin, leading to hyperglycemia and insulin resistance.
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