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Growth Hormone Physiology
Can you name the Growth Hormone Physiology?
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T/F: Growth hormone acts to increase glucose uptake.
this condition is caused by excessive GH before adolescence, which causes increased body size and hyperglycemia.
T/F: Levels of GH increase significantly during the day.
T/F: The chronic release of GH causes an increase in plasma glucose and increase in plasma insulin, leading to hyperglycemia and insulin resistance.
Insulin and IGF-1 receptors are apart of what class of receptors?
This receptor is a clearance receptor that removes its ligand out of circulation and into the cell to undergo lysosomal degradation?
Main role of GH on hepatocytes is to induce the formation of ___.
this condition is caused by excessive GH after adolescence. It does not increase the length of bones but does increase the growth of soft tissues.
T/F: GH acts on proteins by increasing the amino acid intake, increasing protein synthesis, increasing transcription, and decreasing protein degradation.
True or False: IGF acts as a negative feedback regulator of GH release. and acts as a positive feedback regulator of somatostatin release.
T/F: Maximum secretion of GH during life occurs at puberty.
this pathological condition is caused by a deficiency of GH or IGF-1 during childhood. Patients are short (but proportional) with no mental retardation.
glucagon acts to _______ the release of GH.
fasting _____ the release of GH
IGF-1 travels in the blood bound to which protein?
A decrease in blood sugar (hypoglycemia) would ______ the release of GH.
The GHRH _____ the release of growth hormone.
Growth hormone _____ lipolysis.
T/F: When GHRH binds to its receptor intracellularly, it increases cAMP levels and causes an influx of calcium and release of secretory vesicles containing GH.
Main target organ for growth hormone that causes its long term effect related to growth
T/F: Somatostatin can only be made in the hypothalamus.
Which nucleus of the hypothalamus produces Growth Hormone releasing hormone?
The GH receptor at the liver is a unique receptor coupled to the JAK/ STAT pathway which causes production of _____ and its binding protein.
T/F: pvGH is produced by the placenta. It binds to hGH receptor and is extremely important for the development of the fetus.
Where is somatostatin produced in the hypothalamus?
obesity ______ the release of GH
T/F: GH is a protein hormone that has 2 biologically active isoforms
T/F: Growth hormone acts to increase glucose availability for energy purposes.
inhibits the release of GH
short stature or form of dwarfism caused by a lack of GH receptors.
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