Question | Answer |
pathological condition usually caused by a benign parathyroid gland tumor. Results in high PTH, hypercalcemia, hypophophatemia, hypercalinuria and the patient may have kidney stone | |
occurs because of a disruption in PTH signalling (mutation in the Gs protien coupled to PTH receptors in bone and kidney) which results in hypocalcemia and hyperphophatemia and hig | |
True or False: PTH is a steroid hormone. | |
True or False: 1, 25 dihydroxy D3 acts at the intestine to increase Ca and Phosphate absorbption into the blood. | |
What percentage of Phosphate is complexed? | |
Calcitonin is responsible for reducing levels of what ion in the plasma? | |
softening of bones in children due to a Vitamin D deficiency or impaired metabolism of Vitamin D3 | |
True or False: Increased concentration of Phosphate in the kidney, increases the catalytic activity of renal 1 hydroxylase. | |
Which cells of the parathyroid gland synthesize PTH? | |
How is PTH released from the parathyroid gland? | |
True or False: 1, 25, dihydroxy D3 provides a long term negative feedback mechanism for secretion of PTH by acting at the chief cell to decrease PTH synthesis | |
catakyzes the conversion of vitamin D3 to 25monohydroxyD3 | |
True or False: Calcitonin serves to inhibit collagen production and an increases production of proteases to breakdown bone. | |
pathological condition that is caused by a tumor in the adrenal cortex causing an increase in secretion of glucocorticoids which inhibit calcium reabsoption at the kidney and calci | |
True or False: when Ca or P are bound to proteins it can be filtered by the glomerulus and acted on by hormones | |
What percentage of Ca is ionized? | |
softening of bones in adults due to a Vitamin D deficiency or impaired metabolism of Vitamin D3 - defective mineralization | |
pathological condition usually caused by renal failure, in which PTH acts to promote bone resorption but it is unable to act at the kidney ( with inability to synthesize 1, 25 dihy | |
The CaSR receptor is a G protein receptor, and when there are high levels of Ca, the receptor activates a G protein that ____ cAMP levels. | |
PTH receptors are located on what types of cells? | |
The osteoblasts release _____ that cause an increase in number and activity of the osteoclasts | |
this peptide hormone is responsible for the decreasing blood calcium levels | |
PTH is composed of __ amino acids. | |
which protein is responsible for the transport of vitamin D3 and 25 hydroxy D3 | |
occurs as a result of hypoparathyroidism that leads to spontaneous discharge of peripheral motor neurons or muscle spasms and seizures | |
a CaR activator that mimics the effect of high plasma Ca to inhibit PTH synthesis | |
catalyzes the conversion of 25 hydroxy D3 to 1, 25 dihydroxy D3. | |
PTH promotes bone _____. | |
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