Blood Brain Barrier and CSF

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Can you name the concepts concerning Blood Brain Barrier and CSF?

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QuestionAnswer
True or False: The endothelial cells of the BBB have a high concentration of mitochondria because the mitochondria are needed to power energy dependent mechanisms that allow specif
True or False: The CSF is essential in the removal of harmful substances or waste from the brain
circumventricular organ that is chemoreceptive to angiotensin II, and regulates the water balance in the body
This molecule is thought to play a big role in regulating the permeability of endothelial cells of the BBB
A tissue characterized by leaky capillaries and modified ependymal cells
organs with no BBB... line the ventricles
blood clot in or on the brain is known as a _____.
True or False: The Trojan Horse Method for brain delivery includes targeting energy-dependent or facilitative transport to gain access to CNS
The BBB is permeable to substances with a molecular weight upto about ___ daltons.
True or False: The BBB acts as a selectively permeable barrier restricting entry of some hormones and NT, microorganisms, and immunoeffector cells.
What structures act as one way valves, allowing CSF to exit the ventricular system into the venous system?
Circumventricular Organ involved in the secretion of vasopressin and oxytocin
What is the main structural component of the BBB?
What cell is thought to influence the formation of endothelial tight junctions as well as influence the proliferation of endothelial cells?
Where is CSF produced?
What percentage of the Brain is water?
What is the characteristic of endothelial cells of CVOs?
True or False: Tight junctions are found in most endothelial cells in the body.
If there is a hemorrhage in the brain, then the CSF will be what color?
True or False: The Lamina Terminalis has an extensive blood brain barrier.
What acts as a conduit for polypeptide hypothalamic hormones?
a buildup of fluid inside the skull, leading to brain swelling. Can occur early in development preventing normal cranial development
the ______ the lipid solubility (i.e. ability to pass through endothelial membranes), the greater the delivery rate into the brain.
A patent ventricular system characterized by impaired absorption into the venous system is known a _______ hydrocephalus.
QuestionAnswer
How do metabolites (glucose), vitamins, and minerals enter the brain?
This Circumventricular organ regulates the anterior pituitary.
How much CSF is produced per day?
What is the turnover rate for the production of CSF?
CSF occupies what percentage of the total brain weight?
An increase in what 2 molecules or ions leads to vasodilation in cerebral resistance vessels?
True or False: CSF is a combination of NaCl, bicarbonate, and water.
The removal of wastes from the brain is mediated by ______.
This circumventricular organ releases glycoprotein into the CSF
what type of substance typically passes the BBB?
An obstruction of CSF flow (no free passage from lateral ventricles to subarachnoid space) is known as a ________ hydrocephalus.
If there is an increase in proteins or leukocytes, what color with the CSF be?
Complete the Equation: _____=CPP/CVR
An increase in intracranial pressure can cause an increase in Cerebral vascular resistance, which causes a ______ in cerebral blood flow.
What enzyme drives the gradient needed for bicarbonate production used in CSF?
This Circumventricular organ regulates circadian rhythm via melatonin release
coughing, sneezing, hematomas, ateriovenous malformations, and edema can all be causes of increased _______ ______.
proteins that form pores for water transport required for the production of CSF
an increase in optic disc swelling that can be secondary to intracranial pressure
What mediates the transport of glucose into the brain?
True or False: Normal CSF has a cloudy consistency.
___% of the blood from the heart goes to the brain.
True or False. The Area Postrema is a CVO.
High synaptic activity leads to an increase in extracellular Potassium, which leads to ______ of cerebral resistance vessels.

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