Adrenal Cortex physiology

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CAH characterized by salt wasting, normal glucocorticoids, normal androgens, and low blood pressure
T/F: Cortisol acts as a negative feedback regulator at the anterior pituitary and hypothalamus
no steroids are made in this disorder
True or False: 17 a hydroxylase deficiency causes increased blood pressure
patients with an adrenal tumor will have high or low levels of ACTH?
A baby born with 21 hydroxylase deficiency will have _____ mineralocorticoid and glucocorticoid levels.
Gene responsible for encoding for aldosterone synthase
True or False: Cortisol levels generally peak around midnight.
True or False: The melanocortin family of receptors are G protein coupled receptors.
Gene responsible for encoding 21 hydroxylase
Primary Addison's disease is caused by a deficiency of ____.
A baby born with defective CYP21 will have high or low levels of ACTH?
the region of the adrenal cortex that secretes glucocorticoids
True or False: overstimulation of cortisol can cause diabetes.
conversion of cholesterol to pregenolone takes place in what organelle
True or False: A female baby born with defective CYP21 has increased production of DHEA, causing ambiguous genitalia.
A baby born with21 hydroxylase deficiency has ___ blood pressure.
inactive form of cortisol
conversion of 11-deoxycortisol to cortisol is catalyzed by what enzyme
T/F: Adrenal gland size is proportional to the stimulation of the gland.
Gene responsible for encoding 17 a hydroxylase and 17 20 desmolase
can cause ambiguous genitalia in males and absent puberty in females because androgens are not able to be made. can occur as a result of defective CYP17
the region of the adrenal cortex that secretes androgens
defective gene in lipoid hyperplasia
gene responsible for encoding 11 B hydroxysteroid dehydrogenase
True or False: A baby born with 11B hydroxylase deficiency will have increased androgen production leading to ambiguous genitalia in females
A baby born with 11B hydroxylase deficiency high or low blood pressure
Cortisol acts to coordinate actions in the muscle and liver. It causes the release of Amino acids by the muscle for uptake by the liver for what metabolic process?
Cortisol acts to _____ lipolysis.
QuestionAnswer
pregnenolone is converted to progestrone in which organelle of the cell?
responsible for the conversion of corticosterone to aldosterone
True or False: Patients with Cushing's disease have normal circadian rhythm of ACTH release.
True or False: 17 a hydroxylase deficiency causes increased mineralocorticoids and glucocorticoids.
True or False: Cortisol decreases red blood cell production.
steroidogenesis begins with what compound
channel responsible for transporting cholesterol into the mitochondria
these 2 enzymes catalze the conversion of pregnenolone to DHEA.
melanocortin receptor that binds ACTH stimulating steroidogenesis
True or False: Glucocorticoid and Mineralocorticoid receptors are intracellular acting primarily by regulating transcription
Secondary Addison's disease is caused by a deficiency of ____.
T/F: Cortisol can only bind the glucocorticoid receptor.
these 2 enzymes catalze the conversion of pregnenolone to progesterone
True or False: aldosterone synthase deficiency presents with ambiguous genitalia
hormone disorder chasracterized by high levels of ACTH. Patients generally have a redistribution of fat to the truncal areas of the body, with muscle wasting at the extremties
catalyzes the conversion of cortisol to cortisone so that it can be inactivated
Cortisol cause an increase in gluconeogensis and a _____ in glucose uptake.
melanocortin receptor involved in anorexia
the region of the adrenal cortex that secretes mineralocorticoids
this congential adrenal hyperplasia occurs as a result of defective CYP11B2
Gene responsible for encoding 11B hydrolase
melanocortin receptor involved in pigmentation
Gene responsible for encoding 3B hydroxysteroid dehydrogenase
A baby born with 11B hydroxylase deficiency high or low glucocorticoids.
what catalyzes the conversion of cholesterol to pregnenolone?
ADH (vasopressin) and Corticotropin releasing hormone cause the release of what hormone from the anterior pituitary?
catalyzes the conversion of progesterone to 11-deoxycorticosterone
True or False: 17 a hydroxylase deficiency causes increased androgens in the blood
Pro-opiomelanocortin is the precursor for what hormone released from the anterior pituitary?

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