Gastric Physiology

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Can you name the Gastric Physiology?

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Peptide tyrosine-tyrosine (PYY) and glucagon like peptide (GLP1 and GLP2) ____ (stimulates/inhibits) gastric emptying
P/D1 cells release what hormone?
enzyme important for the production of protons and bicarbonate in the parietal cell
which two products of oxidative phosphorylation are important for the production of stomach acid.
The gland of the stomach is known an ____ gland.
This type of drug inhibits prostaglandin related defense mechanisms within the stomach
All stomach cell types are activated by the neurotransmitter (from the enteric nervous system) Acetylcholine, except which cell?
T/F: After a large meal, the alkaline tide (removal of bicarbonate from the parietal cell) causes an increase in the pH of the blood.
The superficial epithelial cells along with which other cell type in the stomach act to lubricate and protect the stomach wall?
How does potassium get out of the parietal cell?
2 causes of peptic ulcers
T/F: Proton pump inhibitors bind irreversibly to the H/K proton pump.
this hormone acts at the hypothalamus to suppress appetite
T/F: Rate of gastric emptying increases with rectal and colonic distention.
failure of the pyloric sphincter to relax for gastric emptying... leads to projectile vomiting
H2 blockers prevent the binding of ____ to prevent the production of acid.
T/F: Tagemet and cimetidine prevent acid production by blocking H1 histamine receptors
The movement of Cl into the parietal cell is coupled to the movement of which ion out of the cell?
Nutrients in the ileum and the colon influence gastric emptying through the _____ mechanism
prilosec or omeprazole acts by inhibiting what?
these cells produce gastrin
T/F: ECL cells can be activated by acetylcholine or gastrin
T/F: Ileal fat increase gastric emptying.
___ are hormones released by the duodenum and cause feedback on stomach to decrease gastric emptying and secretions
made by the I cells of the duodenum
These cells in the stomach are activated by the H+ions in the stomach to reduce the release of gastrin
T/F: An increase in pH (basicity) slows gastric emptying.
Which histamine receptor is found on the basolateral membrane of the parietal cell?
T/F: The stomach is the major site for digestion.
P/D1 cells are located where?
these cells produce HCl and intrinsic factor
pespinogen and HCl are released into the lumen of the stomach... where is histamine released?
these cells produce somatostatin
CCK ____ (promotes or inhibits) gastric emptying
made by the S cells of the duodenum
responsible for getting H+ ions into the lumen of the stomach
T/F: Large volumes in the stomach increase gastric emptying
T/F: The parietal cell can be activated by Acetylcholine, histamine, or gastrin.
occurs due to uncontrolled gastric emptying due to the lack of feedback inhibition by the duodenum and undigested food makes it to the colon
2nd messenger involved in activation of the parietal cell
T/F: Ghelin is released during fasting which stimulates appetite
Hypoglycemia ___ (increase or decreases) gastric emptying.
what activates pepsinogen?
these cells produce histamine
Cl ions are transported into the lumen of the stomach using which type of transport protein?
occurs due to a defiency in vitamin B12, which inhibits the body's ability to go through erythropoesis
T/F: In some cases of peptic ulcer disease, acid from the stomach erodes the D cells of the stomach preventing the brake mechanism for acid production.
Cl ions are transported into the parietal cell using which type of transport protein?
essential for binding and absorption of vitamin B12
these cells produce pepsinogen and gastric lipase
T/F: Prilosec or Omeprazole acts at the basolateral membrane of the parietal cell.
Secretin ____ (promotes or inhibits) gastric emptying
severely delayed gastric emptying or no emptying
this hormone acts on the G cell in the antrum of the stomach to inhibit the release of gastrin
leptin is release by which type of tissue?

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