Gastric Physiology

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Cl ions are transported into the parietal cell using which type of transport protein?
failure of the pyloric sphincter to relax for gastric emptying... leads to projectile vomiting
this hormone acts on the G cell in the antrum of the stomach to inhibit the release of gastrin
Which histamine receptor is found on the basolateral membrane of the parietal cell?
enzyme important for the production of protons and bicarbonate in the parietal cell
T/F: After a large meal, the alkaline tide (removal of bicarbonate from the parietal cell) causes an increase in the pH of the blood.
essential for binding and absorption of vitamin B12
H2 blockers prevent the binding of ____ to prevent the production of acid.
T/F: An increase in pH (basicity) slows gastric emptying.
these cells produce HCl and intrinsic factor
T/F: Large volumes in the stomach increase gastric emptying
P/D1 cells release what hormone?
prilosec or omeprazole acts by inhibiting what?
All stomach cell types are activated by the neurotransmitter (from the enteric nervous system) Acetylcholine, except which cell?
these cells produce gastrin
T/F: The stomach is the major site for digestion.
occurs due to uncontrolled gastric emptying due to the lack of feedback inhibition by the duodenum and undigested food makes it to the colon
T/F: Ileal fat increase gastric emptying.
T/F: Rate of gastric emptying increases with rectal and colonic distention.
T/F: The parietal cell can be activated by Acetylcholine, histamine, or gastrin.
___ are hormones released by the duodenum and cause feedback on stomach to decrease gastric emptying and secretions
T/F: ECL cells can be activated by acetylcholine or gastrin
T/F: Proton pump inhibitors bind irreversibly to the H/K proton pump.
2 causes of peptic ulcers
Secretin ____ (promotes or inhibits) gastric emptying
This type of drug inhibits prostaglandin related defense mechanisms within the stomach
Cl ions are transported into the lumen of the stomach using which type of transport protein?
Hypoglycemia ___ (increase or decreases) gastric emptying.
leptin is release by which type of tissue?
The superficial epithelial cells along with which other cell type in the stomach act to lubricate and protect the stomach wall?
pespinogen and HCl are released into the lumen of the stomach... where is histamine released?
these cells produce somatostatin
2nd messenger involved in activation of the parietal cell
The movement of Cl into the parietal cell is coupled to the movement of which ion out of the cell?
The gland of the stomach is known an ____ gland.
occurs due to a defiency in vitamin B12, which inhibits the body's ability to go through erythropoesis
responsible for getting H+ ions into the lumen of the stomach
severely delayed gastric emptying or no emptying
which two products of oxidative phosphorylation are important for the production of stomach acid.
How does potassium get out of the parietal cell?
this hormone acts at the hypothalamus to suppress appetite
T/F: Prilosec or Omeprazole acts at the basolateral membrane of the parietal cell.
T/F: In some cases of peptic ulcer disease, acid from the stomach erodes the D cells of the stomach preventing the brake mechanism for acid production.
these cells produce histamine
T/F: Ghelin is released during fasting which stimulates appetite
Nutrients in the ileum and the colon influence gastric emptying through the _____ mechanism
P/D1 cells are located where?
what activates pepsinogen?
these cells produce pepsinogen and gastric lipase
made by the S cells of the duodenum
Peptide tyrosine-tyrosine (PYY) and glucagon like peptide (GLP1 and GLP2) ____ (stimulates/inhibits) gastric emptying
T/F: Tagemet and cimetidine prevent acid production by blocking H1 histamine receptors
CCK ____ (promotes or inhibits) gastric emptying
These cells in the stomach are activated by the H+ions in the stomach to reduce the release of gastrin
made by the I cells of the duodenum

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