Cell Signaling

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Can you name the the HYTQ concepts?

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term for molecules that mimics signal of ligand (e.g., drug)
these receptors transduce signals across the plasma membrane via changes in receptor protein conformation that lead to changes in receptor protein activity and/or receptor protein
release mechanism for protein or peptide hormones
term for signal that stably occupies a receptor
G proteins are active when what molecule is bound?
hydrophilic molecules generally bind to _____ receptors.
peptide or protein hormones bind which type of receptor? (cell surface or intracellular)
release mechanism for thyroid hormones
steroid hormones bind which type of receptor? (cell surface or intracellular)
hydrophobic molecules generally bind to _____ receptors.
enzyme that phosphorylates protein target
true or false: intracellular receptors regulate transcription.
these receptors bind to signaling molecules that do not diffuse into cell
thyroid hormones bind which type of receptor? (cell surface or intracellular)
these proteins have multiple protein binding domains and can form multi-protein complexes for signal transduction
this protein inactivates G protein
these receptors bind to signaling molecules that diffuse into the cell
QuestionAnswer
this protein activates G proteins by exchanging GDP for GTP
cAMP binds the ______ subunit of protein kinase A (PKA)
release mechanism for catecholamine hormones
this type of receptor protein is a channel for ion transport
these enzymes remove phosphate groups added by kinases
CRE stands for what?
Cytosolic domain of this receptor either has intrinsic enzymatic activity or activates an associated enzyme. There is no enzyme activity without ligand.
PKA catalytic subunits phosphorylate what?
this term describes steps that “transduce” signal binding to receptor into cellular response(s)
Phosphotyrosines recruit which adaptor protein
which subunit of the G-protein binds GTP and GDP?
Active RTK phosphorylates ______ residues
cAMP is synthesized by what?
catecholamine hormones bind which type of receptor? (cell surface or intracellular)
Ligand binding activates a G-protein (GTP-binding protein). Activated G-protein stimulates (or inhibits) an effector
release mechanism for steroid hormones

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