| Hint | Answer | Extra Info |
| Spanish adventurer, conquered the Axtec | |
| An exchange of plants, animals, and disease during the Age of Discovery | |
| Capital of the Aztec Empire | |
| Portuguese explorer, first reach India via sailing around the Cape of Good Hope | |
| Celebrated Chinese naval commander, led expeditions from 1405 to 1433 | |
| Fleet of more than 130 vessels sent by Philip who lost to Elizabeth's forces in the English Channel | |
| Written by de Oviedo in 1547, was a detailed account of plants, animals, and peoples | |
| Successor to Keita as ruler of Mali, led the celebrated pilgrimage to Mecca in 1324 | |
| Places to which goods were shipped for temporary storage | |
| A result of substantial population growth, import of large amounts of silver from the New World, and high inflation rates | |
| Island in South China Sea, 15th Century Port | |
| Creator God of the Inca | |
| Order by Pope Alexander VI which split South America down the middle and gave everything west of it to Spain, and everything east of it to Portugal | |
| | Hint | Answer | Extra Info |
| Portuguese mariner, commissioned by Spain, first expedition to circumnavigate the globe | |
| Spanish conquistador, landed on the northern coast of Peru and started decades of violence with the Inca | |
| Genoese mariner, first European to discover the Americas | |
| A geographical work written in the second century A.D. which introduced the ideas of latitude and longitude | |
| Largest city in Europe and the Middle East during the mid-fifteenth century, capital of Ottoman Empire | |
| Orders which named Columbus viceroy over any territory he might discover and gave him one-tenth of the material rewards | |
| System in which the Spanish Crown granted conquerors the right to employ groups of Amerindians as agricultural or mining laborers or as tribute payers | |
| Crop native to the South Pacific | |
| School of thought founded on doubt that total certainty or definitive knowledge is ever attainable. | |
| A small, light, three-masted sailing ship developed by the Portuguese | |
| Portuguese monarch, strong financial and moral supporter of Portugal's economic endeavors | |
| Type of European luxury trade controlled by the Ottoman in the eastern Mediterranean, the Portuguese, and the Dutch | |
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