| Antagonists | Cartoon |
|---|
| Mandark | |
| Helga G. Pataki, Wolfgang, Ludwig | |
| Freaky Fred, Katz, LeQuack | |
| Mumm-Ra | |
| General Specific, Lady Richington, ANGRY Scientist | |
| Vegeta, Frieza, Cell | |
| Mojo Jojo, The Amoeba Boys, Him | |
| Roger Klotz | |
| Ed Bighead | |
| The Lobe, Cave Guy, Candlejack | |
| Gargamel | |
| The Red Guy | |
| Queen Beryl, Jedite, Nephlite | |
| Sheldon J. Plankton | |
| | Antagonists | Cartoon |
|---|
| Jessie, James, Gary Oak | |
| Boris Badenov, Natasha Fatale | |
| Megabyte, Hexadecimal, Hack & Slash | |
| Dib | |
| The Blockheads | |
| Dark Kat, Dr. Viper, The Pastmaster | |
| Vicky the Babysitter | |
| Skeletor | |
| Hoggish Greedly | |
| Angelica Pickles | |
| Aku | |
| The Kanker Sisters | |
| Zorak, Moltar, Brak | |
| A guy in a mask | |
|
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