| x | x |
|---|
| HPV does not _______ its genome into host cell DNA, but exists as a separately replicating episome (akin to plasmid replication in bacteria). | |
| HPV _____ wart: They appear as individualized papules or nodules with a rough surface. | |
| A reactivation of VZV that affects mainly the flanks and can be excruciating. | |
| ____ patients: Get disseminated infection of HSV involving respiratory, GI tract, or liver | |
| HPV _____ warts are slightly raised, of skin color or pigmented with flat, slightly rough surface. The face and back of hands are the most common locations. | |
| _______ infection: as per HSV. Visceral dissemination is associated with a mortality rate of 5- 15%. | |
| Varicella zoster: Early ______ therapy is beneficial in reducing acute pain for HZ. Pts will generally also require analgesics. NSAIDS are usually ineffective, and opioids may be r | |
| A common, benign, self-limiting infection in children; typically in the 2-5 year age group. | |
| HSV: Primary (as opposed to reactivation infections) tend to be more severe and have more ______ symptoms (headache, fever, lymphadenopathy, etc). | |
| Herpetic _____: Often seen in health care workers; causes painful ulcerations on fingers (can also be caused by HSV-2). | |
| Diagnosis of HSV. | |
| Enveloped, icosahedral ds DNA viruses. | |
| Smallpox Variola ____: 1% mortality rate. Caused by less virulent strains, or infection in a partially immune host | |
| Nonenveloped dsDNA viruses. Causes persisten infections (even after resolution) | |
| ______ Differentials: chickenpox, vaccinia (cowpox) and other poxvirus diseases [esp. with travel history and/or animal exposure], herpes simplex, measles, acne, insect bites. | |
| The most common complication of herpes zoster, occurring in 10–18% of patients. | |
| ______ is an AIDS-defining illness and is the most common neoplasm in HIV+ pts | |
| Diagnosed histologically from findings of large eosinophilic vacuolated cells. Treatment are ablative techniques (curettage, electrocautery or liquid N2) | |
| _____ infection of HSV: Virus enters cutaneous neurons, and migrates to ganglion where it enters a latent state. | |
| Varicella zoster: The rash is more pronounced on _____ and trunk | |
| Herpes _____: characterized by herpes lesions clustering most often on the neck, chest, face, stomach, and legs of wrestlers and high school athletes | |
| Fever and rash concurrent in _______. | |
| Typically have a carpet-like (verrucous) surface. | |
| _______: Like HSV, especially dangerous to immunocompromised pts, who may develop severe pneumonitis, encephalitis, hepatitis or systemic disease | |
| Causes the development of Kaposi’s sarcoma (KS) in pts with depressed cellular immunity, especially AIDS pts | |
| | x | x |
|---|
| A _____ (papilloma) is a benign, self-limited proliferation of skin that generally will regress over time. | |
| Mortality rate for chicken pox is ~3-9/100,000; up to 15% in children with ___ cell defects. | |
| Virus is highly transmissible via airbrone droplets. | |
| Effective HAART prevents the development of, and treats _____ in in HIV+ pts; modifying immunosuppressive regimen in transplant pts | |
| Pathogen of farm animals; occasionally infects humans (farm workers or veterinarians). Causes solitary cutaneous vesicular mass that later develops a central necrosis, typically on | |
| Smallpox Variola ______: has characteristic vesicular rash and ~30% mortality rate | |
| _______ Vaccine: Live virus vaccine consists of vaccinia, the causative pathogen of cowpox. Vaccine should be given within 4 days of exposure. | |
| HPV: Viral replication causes ____ and prickle cell (stratum spinosum) layers to thicken, with overproduction of keratin (keratosis). | |
| Rash clearly follows a single dermatome | |
| dsDNA enveloped virus: member of Poxvirus family. Only one serotype. Spread by aerosoles. | |
| A second VZV vaccine (Zostavax) was developed to prevent shingles/PHN by boosting a waning cell-mediated immune response to VZV with advancing age greater than _____years old. | |
| Causes nodular, smooth umbilicated papular eruptions with a dimple or pit in the center, generally on the face, trunk, genitals or extremities. | |
| HPV: Virus persists in the ____ cell layer | |
| Bacterial _______: Caused by Staphylococcal colonization of a lesion, from scratching. | |
| _____, attenuated viral vaccine available for chicken pox (Varivax). Recommended for children at 12 and 18 mos. | |
| Rare infection of humans. The virus naturally infects nonhuman primates in the tropical rain forests in Africa. | |
| Fever before rash in ________. | |
| Usually diagnosed from clinical signs (rash, pocks). Electron Microscopy is the gold standard. | |
| HPV _____ wart: Found more in adolescents and young adults on the plantar region of the foot. Caused mainly by HPV type 1. They are commonly painful. | |
| HSV: _____ is the drug of choice. Valacyclovir, famciclovir and penciclovir (topical) are also used. | |
| (enlarged keratinocytes with clear haloes and shrunken nuclei) are characteristic of HPV infection. | |
| Category A bioweapons that may produce cutaneous manifestations include agents causing anthrax, plague, _______, tularemia, and certain viral hemorrhagic fevers. | |
| HSV: Virus travels up the ____ to the root ganglion, where it enters a latent (non-lytic) state. | |
| HSV is ______ and results in cell death, leading to ulceration | |
|
Periodic Table
Planets from the Sun
Digits of Pi
