Russell Derm Pathology

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Can you name the Russell Derm Pathology ?

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Light brown pigmented macule with many dark brown small, scattered macules (2-3mm) and papules on pigmented background. May be very large >15cm. Less common than junctional or comp
Benign follicular appendage tumors (trichilemmomas); internal adenocarcinoma (often breast)
Skin tumor with the worst prognosis.
Large, usually unilateral hyperpigmented, hypertrichotic (=hairy) patch on the shoulder or chest
The current lifetime risk for developing invasive melanoma in the US is 1:___, a 2000% increase since 1930
Histological features are fibrohistiocytic tumor with a storiform growth pattern, trapped subcutaneous fat, and tumor invades subcutaneous fat.
Extension of lentigo maligna (intraepidermal) into the dermis. Long RADIAL GROWTH PHASE.
Firm solid nodule arising most frequently on the trunk. Often develop as aggregated 'protuberant' tumors with a firm indurated plaque or nodule that may sometimes ulcerate.
1-12 mm lentigines around the mouth, on the lips, and on the buccal mucosa, and also on fingers and toes on both the palmar and volar surfaces; absent from the flexor and extensor
Spectrum of disorders characterized by increased numbers of mast cells in the skin and occasionally in other organs. Round to oval, red-brown non-scaling multiple prurituc papules
Histological features are intercellular bridges, keratin, and atypical mitosis.
Activation of _____ by keratinocyte-derived alpha-MSH (melanocyte stimulating hormone) stimulates melanogenesis, melanocyte differentiation and transfer of melanosomes to keratinoc
______ Tumors: Apocrine carcinoma, Cylindroma, Pilomatrixoma, Trichilemmoma, Trichoepithelioma, Sebaceous adenoma and carcinoma.
______ Type Basal Cell Carcinoma: Locally destructive with deep invasion into the underlying stroma. Often requires repeated excisions.
Spitz Nevus: ______ Stain. The positively staining cells in the epidermis are Merkel cells.
Larger than most acquired nevi, often larger than 6mm in diameter. Important signs are size, irregular pigmentation, irregular borders, and accentuated surface.
The most common epithelial skin tumor; most people >50 have them. 'Stuck on' appearance. Benign tumor of keratinocytes.
_____ skin: Large, singly dispersed melanosomes in keratinocytes. Many stage IV melanosomes.
Localized area of dermal edema and erythema (wheal) that occur when lesional skin is rubbed.
The risk of malignant melanoma rises to 1:__, if melanoma in-situ is included
Melanoma warning signs are Asymmetry, Border, Color, Diameter, and _____
_____ blue nevus: must be biopsied to rule out melanoma
Multiple, small, hyperpigmented, asymptomatic papules on the face of >35% of adult African Americans. Appear at puberty. Histologically resembles seborrheic keratosis. Benign.
Hard, spiky, white keratosis on sun- exposed skin often accompanied by telangiectasia
Excessive ___ exposure, particularly early in life, is the single most important risk factor for malignant melanoma.
Name a feature used to estimate the probability of metastatic spread of melanoma.
Benign neoplasms composed of melanocytes, which are neural crest-derived cells that migrate to the epidermis during embryogenesis. Symmetrical, well-circumscribed, small flat macul
Multiple sebaceous adenomas and sebaceous carcinomas associated with hereditary nonpolyposis colorectal carcinomas.
Histological features are hyper and parakeratosis, inflammatory infiltrate in dermis, acanthotic, dysplastic epidermis, and solar elastosis in dermis.
_____ nevus: Histologic features are similar to acquired compound nevus.
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Most common melanoma in patients of African, Hispanic, and Asian descent. Mortality rate is 80-90% within 3-4 years.
Histological features are hyperkeratosis, prominent rete ridges, basal hyperpigmentation, and no melanocyte hyperplasia.
Type of melanoma located on the palm, sole, or under the nail. Differential diagnosis: subungual hematoma.
Not all nevi become melanomas because of ________
Associated with genomic instability including imbalance of telomere-telomerase complex and dicentric chromosomes (2 centromeres). Causes Cardiac Myxomas.
Type of melanoma with no radial growth and invades the dermis directly. 15-30% of cases. Poor prognosis
Autosomal recessive disorder with a defect in nucleotide excision repair
Flat, usually small (0.5cm) macule. Clinically insdistinguishable from junctional nevus.
Autosomal dominant trait associated with germline activating mutations in FGFR3. Thickened, hyperpigmented skin with velvety appearance.
_____ growth phase: invasion of malignant cells into the dermis and vessels.
Histological features are epithelial collarette, central keratin filled 'crater' and prominent dermal inflammatory reaction. Keratinocytes with glassy, keratinized cytoplasm.
Flesh-colored, pedunculated tags of skin in the neck, axilla, groin, or under a woman's breast
Symmetrical cup-shaped umbilicated tumor with a central depression filled with keratin.
Partial _____ in melanoma is an unfavorable prognostic sign.
____ skin: Mostly small melanosomes. Melanosome-comples aggregates are rapidly degraded in keratinocytes. Few stage IV melanosomes.
Small, 1 to several mm in diameter, tan-red or light brown macules. The most common pigmented lesions in fair-skinned and/or red haired individuals.
Lifetime risk of developing melanoma approaches 80-100%
White macules, 2-6mm in diameter. Idiopathic. Once formed, macules do not increase in size. Decreased number of melanocytes with decreased amount of melanin.
Intensely pruritic, polygonal papular eruption with violaceous color and sometimes fine scales
Encodes a regulator of melanocortin receptor signaling
Melanoma and nonmelanoma skin cancers. Defective Nucleotide Excision Repair (NER) leads to an inability of cells to repair DNA damage induced by exposure to UV light and some chemi
Yellow-red pigment. More photolabile than eumelanin. Causes photosensitivity.
Histologic features are lentiginous proliferation of melanocytes at the epidermal-dermal junction, single melanocytes with nuclear atypia, no upward scatter of melanocytes into the
Heavily pigmented, blue black nodule with smooth surface. Often confused with nodular melanoma.
Pinching causes depression in the center. More common in women.
Histological features are clusters of small, darkly staining basaloid tumor cells invade dermis. Palisading at the periphery of tumor nests. Bluish myxoid stroma.
Present at birth. Often much larger than acquired nevi, measuring more than 1.5cm in diameter, occasionally greater than 20cm.
MUTATIONS that diminish the activity of the retinoblastoma (RB) tumor suppressor proteins and ____ tumor suppressor protein are common in both familial and sporadic melanomas
Clark's Level ___: Tumor fills the papillary dermis and pushes against the reticular dermis.
_____ syndrome is the leukemoid form of mycosis fungoides with CD4+ T-helper tumor cells in the peripheral blood.
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Clark's Level____: Invasive into the subcutaneous fat. High risk of metastasis.
Histological features are acanthosis, horn cyst, and hyperkeratosis.
Cutaneous or subcutaneous, usually solitary pink, red, violet, or reddish- brown dome-shaped papule, nodule, or tumor (0.5-5 cm) . Head and extremities (sun-damaged skin) are the m
_____ growth phase: lateral spread of malignant cells in epidermis and papillary dermis
Histological features are club-shaped elongated rete ridges, basal hypermelanosis and an increased number but no nesting of melanocytes. Solar elastosis (damaged elastin fibers) in
Besides lentigines, _____ patients develop benign hamartomatous gastrointestinal polyps, mostly in the jejunum, but the entire bowel may affected.
Extreme hyperkeratosis in Actinic Keratosis may cause development of a cutaneous ______.
multiple basal cell carcinomas; jaw cysts, etc.
Histological features are hyperkeratosis, acanthosis, and benign fibrohistiocystic proliferation.
______ Measurement of Melanoma: Ocular micrometer is used to measure the thickness of the lesion from the stratum granulosum to the greatest depth of tumor invasion.
Type of melanoma that develops on lower extremities and back. 70% of cases. Peak incidence in 4th and 5th decade.
Mutation of _____ gene causes phenotype of red hair, light skin, inability to tan.
Extremely common dermal fibrous tumors. Tends to occur on exposed sites on the limbs and the upper back, especially over the scapula.
Type of melanoma. Malignant cells only in epidermis.
The most common benign sun-induced lesion
_______ blue nevus: if present for a long time, does not need to be biopsied.
Brown-black pigment, Absorbs UV light at 200-1200nm. Protects from UV damage.
Histologic features are elongated rete ridges, increased number of melanocytes in the basal layer. Increased amount of pigment in the keratinocytes.
Usually large, more than 6mm. Most are 10mm at diagnosis. Upward infiltration into the upper epidermis may not be conspicuous.
An autoimmune inflammatory response to an unknown antigen in a nevus results in the disappearance of the nevus. The usual patient is less than 20 years old. Back is the typical loc
Histologic features are non-nested proliferation of highly dendritic heavily pigmented melanocytes surrounded by fibrosis.
A melanocyte-specific enzyme required for melanin synthesis
Dermal edema resembling a hive occurs in normal skin as a result of localized stroking with a pointed Instrument.
Clinically indistinguishable from junctional nevus.
A pale nodule with a central pore. A sphere of epidermis gets oriented inward and buried within the skin.
angiofibromas; mental retardation
Small, skin colored dome-shaped nodule. Benign.
Indurated, scaling, erythematous papules, nodules or plaques that occasionally ulcerate and bleed. Often develops in preexisting actinic keratosis
Well-defined, painless, pearlescent nodule in sun-exposed area of older people. The margin is pink with telangiectasias. The most common malignancy of the skin and the entire body.

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