Hermel/Lin Respiratory Viruses & Drugs

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Can you name the Hermel/Lin Respiratory Viruses & Drugs ?

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Most children infected early in life. Younger children may present with stuffy noses. Often accompanied by conjunctivitis.
Anti-RSV drug that blocks viral transcription and replication. Interferes with the synthesis of guanosine/adenosine triphosphate. Inhibits capping of viral mRNA, inhibits viral RNA polymerase.
Viral ____ protein: a proton channel required for viral uncoating and subsequent nuclear replication.
Member of the Paroviridae, non-enveloped ssDNA virus. Cause bronchiolitis or bronchopneumonia.Illness typified by fever, rhinorrhea, cough, and wheezing. Most patients will have abnormalities seen on CXR.
Used in children or infants with severe RSV to minimize bronchiolitis or pneumonia. Also used for HCV infection and Lassa fever virus.
Anti-RSV drug that increases oral bioavailability with a high fat meal.
Infects bronchiolar epithelium leading to bronchiolar inflammation. Envelope protein G mediate viral attachment. Protein F mediates penetration and syncytia formation.
_____ virus: Prodromal symptoms similar to URT infection, which worsen with rapidly increasing hoarseness, harsh barking cough, and the development of severe respiratory stridor.
Name a viral cause of laryngitis.
Name a viral cause of pharyngitis.
Oral Neuraminidase inhibitor for patients older than 1yo.
Enveloped ssRNA virus. Member of the Paramyxoviridae. Serotypes 1 and 3 are the most common, and are the causes of croup (acute laryngotracheobronchitis).Four serotypes known. Infants and young children less than 5yo are the most common patients.
_______ syndrome: seen in children with influenza and after taking aspirin. Acute, often fatal non-inflammatory encephalopathy.
Virulence factors for influenza.
A pharyngostomatitis caused by several Coxsackie A virus strains (Picornavirus family members)non-enveloped ssRNA virus
Age demographic for RSV and MPV.
Caused by adenovirus strains 4 and 7. Seen in military recruits in the first weeks of basic training or college students in the first weeks of classes. Causes a severe influenza-like syndrome appearing mostly as tracheobronchitis. Shows rapid onset of fever (up to 104), cough, sore throat, malaise, pharyngitis, cervical lymph adenopathy, and rhinorrhea
Inhaled Neuraminidase inhibitor for patients older than 7yo. 2% bioavailability and avoided in asthma and COPD.
Typically follows a viral URTI. 2nd most common disease of childhood. Common viral causes are RSV, parainfluenza, and rhinovirus.
Used for chemoprophylaxis against signs and symptoms of influenza A virus.
Adverse reactions include Hemolytic anemia, skin rash, and depression. Contraindicated in uncorrected anemia and pregnancy.
Greater than 80% of patients are under 4yo. Symptoms are sore throat, anorexia, vomiting. Characterized by ulcerated lesions around the soft palate and uvula.
Self-limited inflammation of the bronchi due to upper airway infection. Usual cause are viral infections of the upper airways including INFLUENZA.
Non-enveloped ssRNA virus with over 100 serotypes. Causes 50-80% of all common colds and destroyed at pH3.Little or no fever
QuestionAnswerExtra Information
Enveloped ssRNA virus. Five strains known to infect humans.
Icosahedral, non-enveloped DNA virus. Most common cause of acute febrile pharyngitis or the common cold in children 6 Subgroups A-F, 41 serotypes. Some cause epidemics especially in military recruits and college students
H1N1 virus caused the ______ flu. Pandemic in 2009. Most cases occurred in children and young adults, and less occurrence in the elderly
Starts with cold-like symptoms, but progesses to fever, cough, dyspnea, expiratory wheezing, rales, and signs of respiratory distress (cyanosis).
SARSCaused by a novel, animal derived coronavirus
Vitamin __: reduces the incidence of respiratory tract infection.
Antigenic ____: results from nucleic acid exchange. Occurs every 10-20 years. Generation of new influenza A virus subtypes via antigenic shift. Pigs are the mixing broth that generate new virus. CHINA = pig supply=Swine flu
Adenoviral disease causing outbreaks in children. Typically associated with swimming pools or summer camps. Affected children show low-grade fever, conjunctivitis, pharyngitis, rhinitis, and cervical adenitis. May also suffer from malaise, headache, diarrhea, and vomiting.
Helpful in reducing symptoms of Parkinson's disease.
Neuraminidase cleaves off ______ acid from the cell receptor for influenza virus so that newlyformed virus particles can be released from the cells.
Antigenic _____: results from from mutations. Mutations alter hemagglutinin epitopes so that neutralizing antibody no longer binds.
Anti-RSV drug that blocks viral entry. Monoclonal antibody against an epitope in the A antigen site on the F fusion protein of RSV. RSV prophylaxis in high risk infants - prematurity, CLD, and congenital heart disease
Name a cause of Viral Pneumonia or Pneumonitis.
Used for influenza prophylaxis and treatment if taken within 2 days of onset of symptoms. Active against influenza A and B.
Nucleoside analogue anti-RSV drug that is phosphorylated (activated) by host cell enzymes.
Adverse reactions include bronchospasm, GI symptoms (Tamiflu), and Psychological effect
Anti-influenza drug that inhibits M2 and blocks viral uncoating.
Name an at-risk population for complications of influenza infection.
Adverse reactions include GI upset, CNS (dopaminergic effects), Teratogenic potential (category C), and peripheral edema.
Enveloped ssRNA virus. Paramyxoviridae. Major cause of lower respiratory tract infections (LRTI) in young children. Causes bronchiolitis, tracheobronchitis, and pneumonia.
Neuraminidase inhibitors that block viral release.
Enveloped ssRNA virus. Paramyxoviridae. May account for 15% of acute bronchiolitis or LRTI.Causes symptoms which are impossible to differentiate from those due to infection by RSV. Most severe cases occur in the first year of life.
Enveloped segmented ssRNA virus. Divided into three Groups (A, B, C). Antigens are Neuraminidase and Hemagglutinin. Group A is the most medically important- has the greatest virulence and spread
Side effects of this Anti-RSV drug include anaphylaxis, infections, skin reactions, GI symptoms.

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