Diuretic Agents

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Can you name the Diuretic Agents ?

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Toxicities: Hypokalemic metabolic alkalosis, hyperuricemia, hyperglycemia, hyponatremia
Toxicities: Ototoxicity, hypovolemia, K wasting, hyperuricemia, hypomagnesemia
Sulfonamide similar to thiazide
Toxicity: Infusion site reactions
Antagonist at V1a and V2 ADH receptors. Reduces water reabsorption and increases plasma Na concentration
Mechanism like amiloride, much less potent, more toxic
Only parenteral thiazide available
Clinical applications: glaucoma, mountain sickness, edema with alkalosis
Toxicity: Hyperkalemic metabolic acidosis
Pharmacologic antagonist of aldosterone
Used for hypertension, mild heart failure, nephrolithiasis, nephrogenic diabetes insipidus
Popular for use with loop agents for synergistic effects
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MOA: Physical osmotic effect on tissue water distribution because it is retained in the vascular compartment
Toxicity: Nausea, vomiting, headache. May enhance congestive heart failure or cause pulmonary edema.
Used for peripheral edema, hypertension, acute hypercalcemia, hyperkalemia, acute renal failure, anion overdose
Not a sulfonamide but has typical loop activity and some uricosuric action loop diuretic
Reduces reabsorption of HCO3- in the kidney causing self limited diuresis
Toxicities: metabolic acidosis, renal stones, hyperammonemia in cirrhotics
MOA: Inhibition of NaCl transporter in the distal convoluted tubule
MOA: Inhibition of the enzyme prevents dehydration of H2CO3 and hydration of CO2
Inhibition of Na/K/Cl transporter in the ascending limb of Henle's loop
Toxicity: Hyperkalemia, gynecomastia
MOA: Blocks epithelial sodium channels in collecting tubules
Like spironolactone, more selective for aldosterone receptor

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Created Feb 12, 2011ReportNominate
Tags:agent, diuretic