Molecular Basis of Cancer

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Can you name the Molecular Basis of Cancer?

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HintGene
Growth factor receptor in which a point mutation leads to MEN II a/b and medullary thyroid cancer
Signal transduction gene in which a point mutation leads to several cancer types
Cell cycle regulation gene in which a translocation can cause mantle cell lymphoma
Activation of this gene counteracts bcl-2
Growth factor receptor whose amplification leads to breast, ovarian, lung and gastric cancer
Nuclear regulation gene in which a translocation can lead to Burkitt's lymphoma
Signal transduction gene in which a translocation leads to CML and ALL
HintGene
Anti apoptosis gene associated with B cell follicular lymphoma
Activation of this gene induced apoptosis
Tumor suppressor gene involved in cell cycle regulation that is associated with retinoblastoma and osteosarcome
Growth factor whose overexpression leads to osteosarcoma and astrocytoma
Tumor supressor gene that is the most common target for alteration in human tumors. Normally regualtes apoptosis in response to DNA damage. Associated with Li Fraumeni syndrome and
Tumor suppressor gene associated with a Wilms tumor
Tumor suppressor gene associated with breast cancer

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