Molecular Basis of Cancer

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Can you name the Molecular Basis of Cancer?

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Tumor supressor gene that is the most common target for alteration in human tumors. Normally regualtes apoptosis in response to DNA damage. Associated with Li Fraumeni syndrome and
Growth factor receptor in which a point mutation leads to MEN II a/b and medullary thyroid cancer
Growth factor receptor whose amplification leads to breast, ovarian, lung and gastric cancer
Tumor suppressor gene involved in cell cycle regulation that is associated with retinoblastoma and osteosarcome
Signal transduction gene in which a translocation leads to CML and ALL
Anti apoptosis gene associated with B cell follicular lymphoma
Activation of this gene counteracts bcl-2
HintGene
Growth factor whose overexpression leads to osteosarcoma and astrocytoma
Nuclear regulation gene in which a translocation can lead to Burkitt's lymphoma
Tumor suppressor gene associated with breast cancer
Cell cycle regulation gene in which a translocation can cause mantle cell lymphoma
Signal transduction gene in which a point mutation leads to several cancer types
Activation of this gene induced apoptosis
Tumor suppressor gene associated with a Wilms tumor

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