Definitions | Terms |
Receptor on naive CD4+ cells that binds to B7 molecule on activated macrophages | |
Thymic cell with both CD4 and CD8 coreceptors is called... | |
Proteins synthesized by many cell types in response to viral infection | |
Antigen dependent point mutations in the hypervariable region of the light and heavy chain in an attempt to increase affinity of antibody to antigen. | |
Product released by macrophages that is chemotactic for neutrophils | |
This subset of chemokines attracts monocytes and T-Cells | |
Treatment for chronic granulomatous disease includes | |
Cytokine that causes fever and induction of adhesion proteins and acute phase proteins | |
This cytokine is secreted by many cell types and can directly kill tumor cells, activate monocytes/macrophages and promotes expression of adhesion molecules | |
Variable regions of MHC-II molecule | |
Product released by macrophages that activates natural killer cells | |
Length of peptides in antigen binding clefts on MHC-II molecules | |
Enzyme needed to convert superoxide into hydrogen peroxide | |
An epitope that comes from the tertiary structure of an protein is considered | |
Coreceptor on cytotoxic T Cells that recognizes MHC-I molecule | |
IL-4, IL-5, IL-6 and IL-13 are released by which T Cell subset? | |
TCR Terminal that is constant | |
Process of using only one light chain allele and one heavy chain allele for recombination | |
If a NK Cell binds to MICA or MICB and binds to MHC-I the target cell will __________. (Live or Die) | |
Enzyme needed to convert hydrogen peroxide into products of oxidative burst | |
Proteins associated with TCR that transduce activation signal into cell | |
This creates a non-specific antigen response by many T-Cells at once causing systemic release of cytokines. | |
Which T Cell subset activates B-Cells, eosinophils and mast cells? | |
Important chemical for light chain rearrangement in B-Cells when heavy chain is on cell surface | |
Product released by macrophages that causes fever and is chemotactic | |
Subunit of NADPH oxidase that is mutated in the X-linked recessive form of chronic granulomatous disease | |
Conserved regions of MHC-II molcules | |
Cytokines are considered ______________ because several different types of cytokines can exert the same effect. | |
Subunit(s) of MHC-I that anchors into the membrane | |
Th-1 and Th-2 are considered... | |
Light chain of the TCR | |
Hallmark of inflammation 'rubor' | |
First immunoglobulin released during secondary immune response | |
Which MHC class displays all cellular proteins | |
The main site of secretion of this cytokine is from CD4+ cells and it causes proliferation/differentiation of T-Cells, B-Cells and/or NK cells | |
Protein that loads antigen fragments onto MHC-II in endosome | |
MHC class with three alpha subunits | |
If a CD4+ cell only binds to Ag/MHC-II complex in the absence of a costimulatory response the cell become... | |
Any substance that can bind with an antibody | |
This cytokine is secreted in the thymic cortex by epitelial cells and from stromal cells of the bone marrow and it causes T-Cell and B-Cell proliferation during development | |
Class switch induced by IL-4 | |
Which T-Cell subset activates macrophages and CTLs and recruits neutrophils, macrophages and lymphocytes? | |
The main site of secretion of this cytokine is from monocytes and macrophages, it is a necessary signal in the costimulatory response for activating naive CD4+ cells. | |
Adhesion molecules on endothelial cells | |
Enzyme in cytosol that processes proteins into 8-10 amino acid polypeptides | |
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