Microbiology/Immunology Terms

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Can you name the Microbiology/Immunology Terms?

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DefinitionsTerms
Decreased numbers of phagocytic cells
Light chain of the TCR
Subunit(s) of MHC-II molecule that anchors into the membrane
CDR is an acronym for...
Exogenous antigen processing takes place in the...
IL-2, IFN gamma and TNF beta are released by which T Cell subset?
Process of using only one light chain allele and one heavy chain allele for recombination
Which disease is characterized by a loss of CD43 (which controls cytoskeletal movement) and is often associated with thrombocytopenia?
Which T-Cell subset activates macrophages and CTLs and recruits neutrophils, macrophages and lymphocytes?
If an antigen has two or more epitopes (identical or not) it is considered.
Which disease is caused by a retrovirus that infects and reduces the amount of CD4+ cells to levels below 200 per cubic mm?
Division of the adaptive immune system that is specialized to deal with extracellular threats
Which disease is characterized by a lack of a functioning thymus, parathyroid gland and congenital heart defects?
Coreceptor on cytotoxic T Cells that recognizes MHC-I molecule
The step in emigration of naive T-cells into secondary lymphoid tissue in which there is further interaction between adhesion molecules causing circulating cells to stop
Proteins synthesized by many cell types in response to viral infection
The main site of secretion of this cytokine is from monocytes and macrophages, it is a necessary signal in the costimulatory response for activating naive CD4+ cells.
If a NK Cell binds to MICA or MICB and does NOT bind to MHC-I the target cell will __________. (Live or Die)
What product, released from CD8 cells, forms holes in the target cell's membrane
MHC-II are found on...
Any substance that can bind with an antibody
This cytokine is released from T-Cells and NK Cells and induces and antiviral state, activates NKCs and promotes class switching to IgG2,3
What enzyme released by CD8 cells enters target cells through pores induced by perforin and cause apoptosis of the target
Length of peptides in antigen binding clefts on MHC-II molecules
Any substance that can bind with an antibody and elicit an immune response
Enzyme needed to convert superoxide into hydrogen peroxide
Autosomal recessive disorder in which phagocytic cells are fully functional but are missing the protein needed to stick to the vessel wall and migrate to the site of infection
Process that takes place at thymic corticomedullary border that kills off lymphocytes that have strong interaction with self proteins
Enzyme in cytosol that processes proteins into 8-10 amino acid polypeptides
NADPH oxidase is needed to make this
An epitope that comes from the tertiary structure of an protein is considered
Class switch induced by IL-5
Subunit of NADPH oxidase that is mutated in the X-linked recessive form of chronic granulomatous disease
IL-4, IL-5, IL-6 and IL-13 are released by which T Cell subset?
Which disease is caused by a selective defect in T-Cell immunity which prevents it from responding to candida albicans infections and is often assiociated with endocrine dysfunctio
Proteins that create channel for peptide fragments to move into ER
This cytokine is secreted in the thymic cortex by epitelial cells and from stromal cells of the bone marrow and it causes T-Cell and B-Cell proliferation during development
An epitope that comes from the primary structure of a protein is called
Stress related molecules
First immunoglobulin released during secondary immune response
If an antigen has only one epitope it is considered...
Phagocytic cell with a lifespan of about 4 days
The main site of secretion of this cytokine is CD4+ cells and it causes B-Cell proliferation and promotes class switching
Cytokines are considered ______________ because they can affect different cell types in different ways
Acute phase of inflammation lasts ___________ hours
DefinitionsTerms
Class switch induced by gamme interferon and transforming growth factor beta
Primary phagocytic cell in the blood
TCR Terminal that is variable
Primary phagocytic cell in tissues
Heavy Chain of the TCR
Product released from mast cells that increases permeability of blood vessels
Associated part of MHC-I molecule that increases stability of the complex
Class switch induced by IL-4
This cytokine is secreted by many cell types and can directly kill tumor cells, activate monocytes/macrophages and promotes expression of adhesion molecules
Hallmark of inflammation 'tumor'
Protein that loads antigen fragments onto MHC-II in endosome
Hallmark of inflammation 'calor'
Cytokines are considered ______________ because several different types of cytokines can exert the same effect.
Receptor on NK cells that binds to MHC I molecules
These cytokines are released by all cells and induces an 'antiviral state' and activates NKCs
In the presence of IL-12, IFN gamma or TGF Beta a naive CD4+ cell will differentiate into what subset?
Product released by macrophages that causes fever and is chemotactic
If a CD4+ cell only binds to Ag/MHC-II complex in the absence of a costimulatory response the cell become...
Subunit(s) of MHC-I that anchors into the membrane
Endogenous antigen processing takes place in the...
Process that takes place in the thymic cortex to confirm that lymphocytes can interact with MHC-I/MHC-II molecules
Which MHC class displays all cellular proteins
Adhesion molecules on circulating leukocytes
Hallmark of inflammation 'dolor'
First immunoglobulin released during primary immune response
Antigen dependent point mutations in the hypervariable region of the light and heavy chain in an attempt to increase affinity of antibody to antigen.
Hallmark of inflammation 'rubor'
Two molecules that are needed for the co stimulatory signal in CD4+ Cell activation
The step in emigration of naive T-cells into secondary lymphoid tissue in which P-selectin and E-selectin on the endothelial cells bind to L-selectin on circulating lymphocytes
Abnormal red blood cell
Proteins synthesized by many cells that interfere with viral replication and activate natural killer cells
Product released by macrophages that is chemotactic for neutrophils
MHC-I are found on...
Variable regions of MHC-II molecule
Final products of oxidative burst
Receptor on naive CD4+ cells that binds to B7 molecule on activated macrophages
Transition of a cell through epithelial cells into tissue
Molecule that marks proteins for degradation after translation
Enzyme needed in oxidative burst that is non-functional in patients with Chronic granulomatous disease (CGD)
Important chemical for light chain rearrangement in B-Cells when heavy chain is on cell surface
Small soluble protein that delivers signals
Th-1 and Th-2 are considered...
Small molecule that can bind with antibody but does not elicit an immune response
Enzyme needed to convert hydrogen peroxide into products of oxidative burst
Protein that is defective in Leukocytes adhesion deficiency
DefinitionsTerms
Chaperone protein that stabilized alpha subunits in ER membrane before association with Beta 2 microglobulin
Interleukin-1, Interleukin-6 and Tumor Necrosis Factor alpha are all
Variable regions of MHC-I molecule
Division of the adaptive immune system specialized to deal with intracellular threats
Portion of human genome that contains MHC genes
Which disease is characterized by a lack of cell-mediated and humoral immunity, opportunistic infections and either a mutation in the IL-2 receptor or mutations in ADA and/or PNP
When a structure has one antigen binding site it is
Features of endosome that break down proteins
Product released by macrophages that activates natural killer cells
The establishment of proliferating microbes on the skin of mucous membranes
Length of peptide in antigen binding cleft in MHC-I molecule
Receptors on phagocytic cells capable of recognizing non-specific features on bacterial cells
Conserved regions of MHC-II molcules
In CD8 cell activation which cytokine will act in place of B7/IL-1 to serve as the second signal?
Conserved region of MHC-I molecule
This creates a non-specific antigen response by many T-Cells at once causing systemic release of cytokines.
What protein on the CD8 cell will bind to a receptor on the target cell to induce apoptosis of the target cell?
This cytokine is secreted only by T-Cells and B-Cells and can directly kill tumor cells, activate monocytes/macrophages and promotes expression of adhesion molecules
MHC class with three alpha subunits
This subset of chemokines attract neutrophils and includes IL-8
Thymic cell with both CD4 and CD8 coreceptors is called...
Cytokine that causes fever and induction of adhesion proteins and acute phase proteins
Chaperone protein that brings MHC-II molecule to endosome from ER
Which T Cell subset activates B-Cells, eosinophils and mast cells?
Recognizes MHC/Ag complex
This subset of chemokines attracts monocytes and T-Cells
Treatment for chronic granulomatous disease includes
If a NK Cell binds to MICA or MICB and binds to MHC-I the target cell will __________. (Live or Die)
In the presence of IL-4 and IL-10 a naive CD4+ cell will differentiate into what subset?
Term that describes the strength of binding between a single paratope and epitope
Adhesion molecules on endothelial cells
Class of MHC that CD8 cells recognize
Coreceptor on Helper T Cells that recognizes MHC-II molecule
There are ______ CDRs on the V-region of the TCR
Chemical that breaks disulfide bonds
Receptors on NK Cells that recognize stress proteins on cells
This cytokine is released by many cell types and acts in attracting other cells
The main site of secretion of this cytokine is from CD4+ cells and it causes proliferation/differentiation of T-Cells, B-Cells and/or NK cells
Disease characterized by defective lysosome/phagosome fusion
'Island' macrophages, giant cells, T-Cells and B-Cells around an inflammatory agent that can't be destroyed
Term that describes the strength of interaction of all paratopes and epitopes
Non-specific bacterial features that are capable of being recognized by PRRs
Main thymic cells involved in negative selection
TCR Terminal that is constant
Proteins associated with TCR that transduce activation signal into cell

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