Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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Deamination reactions create this highly toxic chemical that must be removed from the body.
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
This type of base is sythesized piece by piece directly on the ribose
What type of amino acids are not principally oxidized in the liver?
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
What immune cell carries out de novo synthesis of nucleotides?
This molecule inhibits thymidine kinase
Coverts dihydroorotate to orotate with FAD
Segments rich in what amino acids are rapidly degraded? (acronym)
This enzyme is deficient in histidinemia
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This enzyme can convert Adenosine to Inosine
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
Homocystinuria results from a deficiency of this enzyme
Creatine phosphate donates its phosphate group to ADP after _________________.
This enzyme converts Argininosuccinate to Arginine and Fumarate.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Enzyme that converts THF to N5, N10-methylene THF
In PKU which amino acid becomes essential?
This isoform of CK is found in the heart and is important in diagnosing MIs.
This small, basic protein tags proteins for degradation
Phenylpyruvate and phenylacetate are _____________.
A deficiency of this enzyme would be indicated by Argininemia
________________ have a maple/cheesy smell.
This enzyme catalyzes formation of AMP from adenine and PRPP
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
What amino acid is added to IMP to make AMP?
Branched chain ketoacid dehydrogenase requires what cofactor?
Ezyme that transaminates aspartate
Converts OMP to UMP
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
Increased BUN usually indicates ________________ disease.
What is the base in IMP?
What enzyme converts ribonucleotides to deoxyribonucleotides
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
This enzyme is deficient in albinism.
Condition when uric acid crystals precipitate out of the blood
The cofactor required for transamination reaction is a derivative of ______________.
This molecule activtivates CPS-II
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
Ribose-5-Phostphate is an intermediary in what pathway?
What is the product of the rate limiting step of the urea cycle
20% of SCID cases are due to this enzyme deficiency
ClueAnswer
Deficiency of this enzyme would lead to increased levels of orotic acid
This type of base is assembled completely first then attached to a ribose
Glycine, arginine and methionine are used to synthesize what?
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Bicarbonate, aspartate and ammonia are used to make what?
Enzyme that converts deoyuridine to dUMP
This enzyme adds an ammonium ion to glutamate to make glutamine
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
In a healthy person ketovaline is broken down into ______________>
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
A deficiency of this enzyme would be indicated by citrullinemia.
How is maple syrup urine disease treated?
CPS-II is most sensitive to PRPP during what cell phase?
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
This enzyme converts UTP to CTP
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
The most commonly inherited urea enzyme deficiency
This molecule inhibits CPS-II
The methyl group needed for the conversion of dUMP to dTMP comes from...
Ketogenic amino acids yield which compound(s)?
This enzyme converts neucleotides to nucleosides
Converts orotate to OMP
This genetic disease is characterized by self-mutilating behavior
Decreased BUN usually indicates ______________ disease.
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
Treatment for Lesch-Nyhan Sydrome?
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
What substrate is used to synthesize PRPP?
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
What enzyme is deficient in alkaptonuria?
What amino acids are purely ketogenic?
Purine nucleosides are converted to free bases by what enzyme?
This enzyme converts Xanthine to Uric Acid
This enzyme combines citrulline and aspartate to argininosuccinate
What amino acid is added to IMP to make GMP?
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
CPS-II is most sensitive to UTP during the end of which cell phase?
ClueAnswer
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
If the CK found in the heart is greater than ______ U/L then an MI is probable.
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
What enzyme synthesizes PRPP?
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
CTP Synthase aminates UTP with an amino group from where?
A deposit of urate crystals in someone with gout
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Enzyme that converts thymidine to TMP
PRPP synthase is negatively regulated by ________________
What are uric acid crystals interacting with in gouty arthritis?
This enzyme converts hypoxanthine to xanthine
Creatine kinase is only made in muscle cells that are _________________.
Most de novo nucleotide synthesis occurs where?
People with hyperammonemia are given ________________ so the body uses it for energy of protein
Normal BUN:Creatinine level is ____________:1
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This amino acid is used in the production of melanin
This enzyme converts creatine to creatine phosphate.
The most effective treatment for SCID
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
This is a common cause of acquired hyperammonemia.
________________ cause poor myelination and mental retardation.
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
What amino acid donates an amino group to PRPP?
Enzyme that transaminates alanine
Enzyme that converts dUMP to dMP
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
This enzyme converts dihydrofolate to tetrahydrofolate
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Since humans can't store purines we must get rid of them in this form
Lysosomal proteases that degrade protein in the lysosomal pathway
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
This molecule allosterically activates CPS-I
What is molecule is 'activated ribose'?
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
Elimination of an amino group
What molecule is at the branch point of de novo purine synthesis?
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Presence of creatine kinase in the blood can indicate ___________________.
Deficient enzyme in maple syrup urine disease

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein