Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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ClueAnswer
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
This enzyme converts UTP to CTP
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Coverts dihydroorotate to orotate with FAD
In a healthy person ketovaline is broken down into ______________>
Creatine phosphate donates its phosphate group to ADP after _________________.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
This molecule inhibits thymidine kinase
This enzyme converts hypoxanthine to xanthine
What is the product of the rate limiting step of the urea cycle
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Presence of creatine kinase in the blood can indicate ___________________.
Purine nucleosides are converted to free bases by what enzyme?
Phenylpyruvate and phenylacetate are _____________.
A deficiency of this enzyme would be indicated by Argininemia
This molecule allosterically activates CPS-I
This type of base is sythesized piece by piece directly on the ribose
Ribose-5-Phostphate is an intermediary in what pathway?
If the CK found in the heart is greater than ______ U/L then an MI is probable.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
Segments rich in what amino acids are rapidly degraded? (acronym)
This enzyme adds an ammonium ion to glutamate to make glutamine
Increased BUN usually indicates ________________ disease.
Enzyme that converts dUMP to dMP
This enzyme converts dihydrofolate to tetrahydrofolate
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
This is a common cause of acquired hyperammonemia.
This enzyme combines citrulline and aspartate to argininosuccinate
What are uric acid crystals interacting with in gouty arthritis?
Elimination of an amino group
What immune cell carries out de novo synthesis of nucleotides?
A deposit of urate crystals in someone with gout
In PKU which amino acid becomes essential?
The most commonly inherited urea enzyme deficiency
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
This enzyme converts Argininosuccinate to Arginine and Fumarate.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
Converts OMP to UMP
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
What substrate is used to synthesize PRPP?
What enzyme synthesizes PRPP?
ClueAnswer
What amino acid is added to IMP to make AMP?
The most effective treatment for SCID
What amino acid is added to IMP to make GMP?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
This enzyme is deficient in albinism.
This genetic disease is characterized by self-mutilating behavior
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
Homocystinuria results from a deficiency of this enzyme
People with hyperammonemia are given ________________ so the body uses it for energy of protein
CPS-II is most sensitive to PRPP during what cell phase?
________________ cause poor myelination and mental retardation.
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This enzyme can convert Adenosine to Inosine
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
PRPP synthase is negatively regulated by ________________
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
This enzyme converts neucleotides to nucleosides
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
This enzyme catalyzes formation of AMP from adenine and PRPP
This molecule inhibits CPS-II
How is maple syrup urine disease treated?
What molecule is at the branch point of de novo purine synthesis?
Creatine kinase is only made in muscle cells that are _________________.
What enzyme is deficient in alkaptonuria?
Ketogenic amino acids yield which compound(s)?
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Ezyme that transaminates aspartate
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
This enzyme is deficient in histidinemia
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
What enzyme converts ribonucleotides to deoxyribonucleotides
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
________________ have a maple/cheesy smell.
CTP Synthase aminates UTP with an amino group from where?
20% of SCID cases are due to this enzyme deficiency
What is the base in IMP?
Branched chain ketoacid dehydrogenase requires what cofactor?
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
Treatment for Lesch-Nyhan Sydrome?
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
Bicarbonate, aspartate and ammonia are used to make what?
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
Converts orotate to OMP
CPS-II is most sensitive to UTP during the end of which cell phase?
Enzyme that transaminates alanine
ClueAnswer
This small, basic protein tags proteins for degradation
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Condition when uric acid crystals precipitate out of the blood
Enzyme that converts THF to N5, N10-methylene THF
What amino acids are purely ketogenic?
This type of base is assembled completely first then attached to a ribose
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
Enzyme that converts deoyuridine to dUMP
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
Deficiency of this enzyme would lead to increased levels of orotic acid
This molecule activtivates CPS-II
Deamination reactions create this highly toxic chemical that must be removed from the body.
What is molecule is 'activated ribose'?
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
Since humans can't store purines we must get rid of them in this form
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
This amino acid is used in the production of melanin
This isoform of CK is found in the heart and is important in diagnosing MIs.
Lysosomal proteases that degrade protein in the lysosomal pathway
What type of amino acids are not principally oxidized in the liver?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
Most de novo nucleotide synthesis occurs where?
This enzyme converts creatine to creatine phosphate.
The cofactor required for transamination reaction is a derivative of ______________.
A deficiency of this enzyme would be indicated by citrullinemia.
Enzyme that converts thymidine to TMP
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
Glycine, arginine and methionine are used to synthesize what?
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
This enzyme converts Xanthine to Uric Acid
The methyl group needed for the conversion of dUMP to dTMP comes from...
Normal BUN:Creatinine level is ____________:1
Deficient enzyme in maple syrup urine disease
Decreased BUN usually indicates ______________ disease.
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
What amino acid donates an amino group to PRPP?
What immune cell uses primarily the salvage pathway for nucleotide synthesis?

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein