Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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Since humans can't store purines we must get rid of them in this form
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
This enzyme adds an ammonium ion to glutamate to make glutamine
This small, basic protein tags proteins for degradation
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Treatment for Lesch-Nyhan Sydrome?
What enzyme is deficient in alkaptonuria?
Lysosomal proteases that degrade protein in the lysosomal pathway
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
Decreased BUN usually indicates ______________ disease.
This molecule inhibits CPS-II
The most effective treatment for SCID
What is molecule is 'activated ribose'?
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This enzyme is deficient in histidinemia
Purine nucleosides are converted to free bases by what enzyme?
In a healthy person ketovaline is broken down into ______________>
CPS-II is most sensitive to UTP during the end of which cell phase?
Increased BUN usually indicates ________________ disease.
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
Ezyme that transaminates aspartate
What enzyme converts ribonucleotides to deoxyribonucleotides
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Normal BUN:Creatinine level is ____________:1
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
This enzyme converts dihydrofolate to tetrahydrofolate
Enzyme that transaminates alanine
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
PRPP synthase is negatively regulated by ________________
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
What amino acid is added to IMP to make AMP?
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Homocystinuria results from a deficiency of this enzyme
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
Deficient enzyme in maple syrup urine disease
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
The methyl group needed for the conversion of dUMP to dTMP comes from...
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
This is a common cause of acquired hyperammonemia.
Presence of creatine kinase in the blood can indicate ___________________.
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
The most commonly inherited urea enzyme deficiency
What amino acid donates an amino group to PRPP?
What amino acids are purely ketogenic?
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
What are uric acid crystals interacting with in gouty arthritis?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
People with hyperammonemia are given ________________ so the body uses it for energy of protein
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
A deposit of urate crystals in someone with gout
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
What enzyme synthesizes PRPP?
This enzyme combines citrulline and aspartate to argininosuccinate
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
________________ have a maple/cheesy smell.
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
This enzyme can convert Adenosine to Inosine
A deficiency of this enzyme would be indicated by citrullinemia.
This molecule inhibits thymidine kinase
What molecule is at the branch point of de novo purine synthesis?
Deficiency of this enzyme would lead to increased levels of orotic acid
What is the product of the rate limiting step of the urea cycle
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
The cofactor required for transamination reaction is a derivative of ______________.
This enzyme converts creatine to creatine phosphate.
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
Bicarbonate, aspartate and ammonia are used to make what?
In PKU which amino acid becomes essential?
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Branched chain ketoacid dehydrogenase requires what cofactor?
What amino acid is added to IMP to make GMP?
Deamination reactions create this highly toxic chemical that must be removed from the body.
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
This isoform of CK is found in the heart and is important in diagnosing MIs.
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This genetic disease is characterized by self-mutilating behavior
Converts orotate to OMP
What immune cell carries out de novo synthesis of nucleotides?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
This molecule activtivates CPS-II
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
Ketogenic amino acids yield which compound(s)?
CTP Synthase aminates UTP with an amino group from where?
Converts OMP to UMP
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
Creatine kinase is only made in muscle cells that are _________________.
Segments rich in what amino acids are rapidly degraded? (acronym)
What type of amino acids are not principally oxidized in the liver?
Enzyme that converts THF to N5, N10-methylene THF
20% of SCID cases are due to this enzyme deficiency
Elimination of an amino group
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
What is the base in IMP?
This amino acid is used in the production of melanin
What substrate is used to synthesize PRPP?
How is maple syrup urine disease treated?
This enzyme converts Xanthine to Uric Acid
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
This enzyme is deficient in albinism.
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This enzyme converts Argininosuccinate to Arginine and Fumarate.
Enzyme that converts dUMP to dMP
This enzyme converts hypoxanthine to xanthine
CPS-II is most sensitive to PRPP during what cell phase?
Creatine phosphate donates its phosphate group to ADP after _________________.
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
This type of base is assembled completely first then attached to a ribose
Enzyme that converts thymidine to TMP
This molecule allosterically activates CPS-I
A deficiency of this enzyme would be indicated by Argininemia
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
Enzyme that converts deoyuridine to dUMP
This type of base is sythesized piece by piece directly on the ribose
Condition when uric acid crystals precipitate out of the blood
Most de novo nucleotide synthesis occurs where?
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
Phenylpyruvate and phenylacetate are _____________.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
This enzyme converts neucleotides to nucleosides
This enzyme converts UTP to CTP
Coverts dihydroorotate to orotate with FAD
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Glycine, arginine and methionine are used to synthesize what?
Ribose-5-Phostphate is an intermediary in what pathway?
This enzyme catalyzes formation of AMP from adenine and PRPP
________________ cause poor myelination and mental retardation.
If the CK found in the heart is greater than ______ U/L then an MI is probable.

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein