Biochemistry: Protein and Nucleotide Metabolism

Random Science Quiz

Can you name the Biochemistry: Protein and Nucleotide Metabolism?

Quiz not verified by Sporcle

 plays        
How to Play
ClueAnswer
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
The most effective treatment for SCID
This enzyme converts hypoxanthine to xanthine
This enzyme converts neucleotides to nucleosides
Since humans can't store purines we must get rid of them in this form
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
Normal BUN:Creatinine level is ____________:1
Segments rich in what amino acids are rapidly degraded? (acronym)
What enzyme converts ribonucleotides to deoxyribonucleotides
Decreased BUN usually indicates ______________ disease.
Presence of creatine kinase in the blood can indicate ___________________.
Increased BUN usually indicates ________________ disease.
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
What molecule is at the branch point of de novo purine synthesis?
What is molecule is 'activated ribose'?
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
This genetic disease is characterized by self-mutilating behavior
This enzyme combines citrulline and aspartate to argininosuccinate
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
A deficiency of this enzyme would be indicated by Argininemia
People with hyperammonemia are given ________________ so the body uses it for energy of protein
This type of base is assembled completely first then attached to a ribose
This enzyme can convert Adenosine to Inosine
Converts orotate to OMP
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Enzyme that converts deoyuridine to dUMP
Ribose-5-Phostphate is an intermediary in what pathway?
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
What is the product of the rate limiting step of the urea cycle
This enzyme converts Argininosuccinate to Arginine and Fumarate.
This isoform of CK is found in the heart and is important in diagnosing MIs.
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
CPS-II is most sensitive to UTP during the end of which cell phase?
What substrate is used to synthesize PRPP?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
A deposit of urate crystals in someone with gout
CTP Synthase aminates UTP with an amino group from where?
The most commonly inherited urea enzyme deficiency
What immune cell carries out de novo synthesis of nucleotides?
Deficient enzyme in maple syrup urine disease
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
This type of base is sythesized piece by piece directly on the ribose
ClueAnswer
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
Phenylpyruvate and phenylacetate are _____________.
Deficiency of this enzyme would lead to increased levels of orotic acid
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This enzyme adds an ammonium ion to glutamate to make glutamine
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
PRPP synthase is negatively regulated by ________________
This enzyme is deficient in histidinemia
20% of SCID cases are due to this enzyme deficiency
What amino acid is added to IMP to make AMP?
Treatment for Lesch-Nyhan Sydrome?
This enzyme converts dihydrofolate to tetrahydrofolate
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
CPS-II is most sensitive to PRPP during what cell phase?
Lysosomal proteases that degrade protein in the lysosomal pathway
Enzyme that transaminates alanine
If the CK found in the heart is greater than ______ U/L then an MI is probable.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Purine nucleosides are converted to free bases by what enzyme?
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
What enzyme synthesizes PRPP?
This enzyme converts creatine to creatine phosphate.
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
This enzyme catalyzes formation of AMP from adenine and PRPP
Glycine, arginine and methionine are used to synthesize what?
This molecule allosterically activates CPS-I
This enzyme converts Xanthine to Uric Acid
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
Enzyme that converts thymidine to TMP
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
Creatine phosphate donates its phosphate group to ADP after _________________.
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
What amino acids are purely ketogenic?
The cofactor required for transamination reaction is a derivative of ______________.
Condition when uric acid crystals precipitate out of the blood
Creatine kinase is only made in muscle cells that are _________________.
Bicarbonate, aspartate and ammonia are used to make what?
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
This molecule activtivates CPS-II
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
Converts OMP to UMP
This enzyme converts Carbamoyl aspartate to Dihydroorotate
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
What is the base in IMP?
ClueAnswer
Homocystinuria results from a deficiency of this enzyme
Coverts dihydroorotate to orotate with FAD
What type of amino acids are not principally oxidized in the liver?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
Branched chain ketoacid dehydrogenase requires what cofactor?
Elimination of an amino group
This small, basic protein tags proteins for degradation
What are uric acid crystals interacting with in gouty arthritis?
This enzyme converts UTP to CTP
Most de novo nucleotide synthesis occurs where?
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
This molecule inhibits CPS-II
________________ have a maple/cheesy smell.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
This enzyme is deficient in albinism.
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
________________ cause poor myelination and mental retardation.
This is a common cause of acquired hyperammonemia.
Enzyme that converts THF to N5, N10-methylene THF
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
Ketogenic amino acids yield which compound(s)?
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
In PKU which amino acid becomes essential?
What amino acid is added to IMP to make GMP?
Ezyme that transaminates aspartate
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
Enzyme that converts dUMP to dMP
Deamination reactions create this highly toxic chemical that must be removed from the body.
What amino acid donates an amino group to PRPP?
What enzyme is deficient in alkaptonuria?
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
A deficiency of this enzyme would be indicated by citrullinemia.
This molecule inhibits thymidine kinase
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
In a healthy person ketovaline is broken down into ______________>
This amino acid is used in the production of melanin
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
The methyl group needed for the conversion of dUMP to dTMP comes from...
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
How is maple syrup urine disease treated?
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?

Friend Scores


  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...

Extras

Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein