Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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ClueAnswer
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
This small, basic protein tags proteins for degradation
Creatine phosphate donates its phosphate group to ADP after _________________.
Coverts dihydroorotate to orotate with FAD
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
Enzyme that converts thymidine to TMP
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
This enzyme converts creatine to creatine phosphate.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Decreased BUN usually indicates ______________ disease.
PRPP synthase is negatively regulated by ________________
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
A deficiency of this enzyme would be indicated by citrullinemia.
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
What is the product of the rate limiting step of the urea cycle
What amino acid is added to IMP to make AMP?
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
This enzyme is deficient in histidinemia
The most commonly inherited urea enzyme deficiency
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
Increased BUN usually indicates ________________ disease.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
This type of base is assembled completely first then attached to a ribose
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
This enzyme converts Carbamoyl aspartate to Dihydroorotate
What immune cell carries out de novo synthesis of nucleotides?
This enzyme can convert Adenosine to Inosine
________________ cause poor myelination and mental retardation.
The methyl group needed for the conversion of dUMP to dTMP comes from...
This molecule activtivates CPS-II
Segments rich in what amino acids are rapidly degraded? (acronym)
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
Deamination reactions create this highly toxic chemical that must be removed from the body.
What amino acid donates an amino group to PRPP?
Homocystinuria results from a deficiency of this enzyme
This enzyme catalyzes formation of AMP from adenine and PRPP
Since humans can't store purines we must get rid of them in this form
This molecule allosterically activates CPS-I
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
What amino acids are purely ketogenic?
This enzyme converts UTP to CTP
What molecule is at the branch point of de novo purine synthesis?
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Enzyme that converts deoyuridine to dUMP
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
ClueAnswer
Glycine, arginine and methionine are used to synthesize what?
Deficiency of this enzyme would lead to increased levels of orotic acid
This enzyme converts Xanthine to Uric Acid
This enzyme combines citrulline and aspartate to argininosuccinate
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
What are uric acid crystals interacting with in gouty arthritis?
This molecule inhibits CPS-II
Lysosomal proteases that degrade protein in the lysosomal pathway
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
A deposit of urate crystals in someone with gout
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
What is molecule is 'activated ribose'?
Enzyme that converts THF to N5, N10-methylene THF
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Ketogenic amino acids yield which compound(s)?
This amino acid is used in the production of melanin
Converts OMP to UMP
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
What is the base in IMP?
What amino acid is added to IMP to make GMP?
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
This enzyme adds an ammonium ion to glutamate to make glutamine
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
Enzyme that transaminates alanine
What enzyme is deficient in alkaptonuria?
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Most de novo nucleotide synthesis occurs where?
What substrate is used to synthesize PRPP?
This molecule inhibits thymidine kinase
The cofactor required for transamination reaction is a derivative of ______________.
Phenylpyruvate and phenylacetate are _____________.
How is maple syrup urine disease treated?
20% of SCID cases are due to this enzyme deficiency
Elimination of an amino group
Ribose-5-Phostphate is an intermediary in what pathway?
Branched chain ketoacid dehydrogenase requires what cofactor?
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
CPS-II is most sensitive to PRPP during what cell phase?
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
Purine nucleosides are converted to free bases by what enzyme?
If the CK found in the heart is greater than ______ U/L then an MI is probable.
This enzyme converts neucleotides to nucleosides
ClueAnswer
This type of base is sythesized piece by piece directly on the ribose
________________ have a maple/cheesy smell.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
This enzyme converts hypoxanthine to xanthine
In a healthy person ketovaline is broken down into ______________>
Treatment for Lesch-Nyhan Sydrome?
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Bicarbonate, aspartate and ammonia are used to make what?
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This is a common cause of acquired hyperammonemia.
Deficient enzyme in maple syrup urine disease
The most effective treatment for SCID
Enzyme that converts dUMP to dMP
Condition when uric acid crystals precipitate out of the blood
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
What type of amino acids are not principally oxidized in the liver?
This enzyme is deficient in albinism.
Ezyme that transaminates aspartate
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
What enzyme synthesizes PRPP?
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This enzyme converts Argininosuccinate to Arginine and Fumarate.
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
What enzyme converts ribonucleotides to deoxyribonucleotides
Normal BUN:Creatinine level is ____________:1
This isoform of CK is found in the heart and is important in diagnosing MIs.
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
Converts orotate to OMP
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
This genetic disease is characterized by self-mutilating behavior
A deficiency of this enzyme would be indicated by Argininemia
CTP Synthase aminates UTP with an amino group from where?
People with hyperammonemia are given ________________ so the body uses it for energy of protein
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
Presence of creatine kinase in the blood can indicate ___________________.
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
Creatine kinase is only made in muscle cells that are _________________.
CPS-II is most sensitive to UTP during the end of which cell phase?
In PKU which amino acid becomes essential?
This enzyme converts dihydrofolate to tetrahydrofolate
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein