Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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This amino acid has two amino groups and is thus the most efficient carrier of ammonia
In a healthy person ketovaline is broken down into ______________>
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Enzyme that transaminates alanine
This enzyme converts Xanthine to Uric Acid
Segments rich in what amino acids are rapidly degraded? (acronym)
The cofactor required for transamination reaction is a derivative of ______________.
What enzyme is deficient in alkaptonuria?
________________ have a maple/cheesy smell.
This enzyme catalyzes formation of AMP from adenine and PRPP
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
This enzyme converts neucleotides to nucleosides
Presence of creatine kinase in the blood can indicate ___________________.
Phenylpyruvate and phenylacetate are _____________.
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
This is a common cause of acquired hyperammonemia.
Ezyme that transaminates aspartate
This isoform of CK is found in the heart and is important in diagnosing MIs.
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
If the CK found in the heart is greater than ______ U/L then an MI is probable.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Coverts dihydroorotate to orotate with FAD
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
What immune cell carries out de novo synthesis of nucleotides?
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This enzyme converts hypoxanthine to xanthine
Deamination reactions create this highly toxic chemical that must be removed from the body.
This enzyme converts creatine to creatine phosphate.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
What is molecule is 'activated ribose'?
Creatine kinase is only made in muscle cells that are _________________.
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
The most commonly inherited urea enzyme deficiency
This enzyme converts UTP to CTP
What enzyme converts ribonucleotides to deoxyribonucleotides
What is the product of the rate limiting step of the urea cycle
What type of amino acids are not principally oxidized in the liver?
Deficient enzyme in maple syrup urine disease
Ribose-5-Phostphate is an intermediary in what pathway?
Condition when uric acid crystals precipitate out of the blood
Enzyme that converts THF to N5, N10-methylene THF
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
Branched chain ketoacid dehydrogenase requires what cofactor?
What amino acid is added to IMP to make GMP?
This type of base is assembled completely first then attached to a ribose
This enzyme combines citrulline and aspartate to argininosuccinate
This genetic disease is characterized by self-mutilating behavior
Enzyme that converts dUMP to dMP
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
What molecule is at the branch point of de novo purine synthesis?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
What amino acid donates an amino group to PRPP?
This enzyme is deficient in histidinemia
This enzyme can convert Adenosine to Inosine
CPS-II is most sensitive to UTP during the end of which cell phase?
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
Deficiency of this enzyme would lead to increased levels of orotic acid
________________ cause poor myelination and mental retardation.
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This amino acid is used in the production of melanin
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
A deficiency of this enzyme would be indicated by citrullinemia.
CTP Synthase aminates UTP with an amino group from where?
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
The most effective treatment for SCID
This enzyme converts dihydrofolate to tetrahydrofolate
In PKU which amino acid becomes essential?
Enzyme that converts deoyuridine to dUMP
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
Elimination of an amino group
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
This type of base is sythesized piece by piece directly on the ribose
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
Converts orotate to OMP
What is the base in IMP?
PRPP synthase is negatively regulated by ________________
This enzyme adds an ammonium ion to glutamate to make glutamine
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Glycine, arginine and methionine are used to synthesize what?
Creatine phosphate donates its phosphate group to ADP after _________________.
This enzyme converts Argininosuccinate to Arginine and Fumarate.
People with hyperammonemia are given ________________ so the body uses it for energy of protein
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
Normal BUN:Creatinine level is ____________:1
CPS-II is most sensitive to PRPP during what cell phase?
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
Treatment for Lesch-Nyhan Sydrome?
A deposit of urate crystals in someone with gout
This enzyme is deficient in albinism.
Lysosomal proteases that degrade protein in the lysosomal pathway
This enzyme converts Carbamoyl aspartate to Dihydroorotate
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
This molecule inhibits thymidine kinase
Enzyme that converts thymidine to TMP
This small, basic protein tags proteins for degradation
A deficiency of this enzyme would be indicated by Argininemia
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This molecule allosterically activates CPS-I
This molecule activtivates CPS-II
Converts OMP to UMP
What amino acid is added to IMP to make AMP?
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
The methyl group needed for the conversion of dUMP to dTMP comes from...
Homocystinuria results from a deficiency of this enzyme
Decreased BUN usually indicates ______________ disease.
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
What substrate is used to synthesize PRPP?
Increased BUN usually indicates ________________ disease.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Purine nucleosides are converted to free bases by what enzyme?
Since humans can't store purines we must get rid of them in this form
How is maple syrup urine disease treated?
What are uric acid crystals interacting with in gouty arthritis?
What amino acids are purely ketogenic?
What enzyme synthesizes PRPP?
This molecule inhibits CPS-II
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
Bicarbonate, aspartate and ammonia are used to make what?
Most de novo nucleotide synthesis occurs where?
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
20% of SCID cases are due to this enzyme deficiency
Ketogenic amino acids yield which compound(s)?

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein