Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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ClueAnswer
Phenylpyruvate and phenylacetate are _____________.
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
Decreased BUN usually indicates ______________ disease.
What enzyme is deficient in alkaptonuria?
This enzyme converts hypoxanthine to xanthine
What is the product of the rate limiting step of the urea cycle
This enzyme catalyzes formation of AMP from adenine and PRPP
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
A deficiency of this enzyme would be indicated by Argininemia
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
What enzyme converts ribonucleotides to deoxyribonucleotides
Enzyme that converts dUMP to dMP
This enzyme can convert Adenosine to Inosine
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
CPS-II is most sensitive to UTP during the end of which cell phase?
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Ezyme that transaminates aspartate
Purine nucleosides are converted to free bases by what enzyme?
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
The cofactor required for transamination reaction is a derivative of ______________.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Since humans can't store purines we must get rid of them in this form
A deposit of urate crystals in someone with gout
What enzyme synthesizes PRPP?
________________ have a maple/cheesy smell.
Enzyme that converts deoyuridine to dUMP
This enzyme converts neucleotides to nucleosides
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
This molecule inhibits thymidine kinase
What amino acid is added to IMP to make AMP?
The most commonly inherited urea enzyme deficiency
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
In PKU which amino acid becomes essential?
The methyl group needed for the conversion of dUMP to dTMP comes from...
This amino acid is used in the production of melanin
People with hyperammonemia are given ________________ so the body uses it for energy of protein
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
This is a common cause of acquired hyperammonemia.
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
This genetic disease is characterized by self-mutilating behavior
Deficiency of this enzyme would lead to increased levels of orotic acid
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
ClueAnswer
This enzyme adds an ammonium ion to glutamate to make glutamine
If the CK found in the heart is greater than ______ U/L then an MI is probable.
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
________________ cause poor myelination and mental retardation.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
Most de novo nucleotide synthesis occurs where?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
How is maple syrup urine disease treated?
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
This type of base is assembled completely first then attached to a ribose
Enzyme that converts THF to N5, N10-methylene THF
CPS-II is most sensitive to PRPP during what cell phase?
Segments rich in what amino acids are rapidly degraded? (acronym)
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
Deamination reactions create this highly toxic chemical that must be removed from the body.
This enzyme converts Xanthine to Uric Acid
This enzyme combines citrulline and aspartate to argininosuccinate
Creatine kinase is only made in muscle cells that are _________________.
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
What amino acids are purely ketogenic?
What substrate is used to synthesize PRPP?
What is molecule is 'activated ribose'?
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
The most effective treatment for SCID
What amino acid donates an amino group to PRPP?
Coverts dihydroorotate to orotate with FAD
Converts orotate to OMP
A deficiency of this enzyme would be indicated by citrullinemia.
This small, basic protein tags proteins for degradation
Treatment for Lesch-Nyhan Sydrome?
This enzyme is deficient in histidinemia
Glycine, arginine and methionine are used to synthesize what?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
Bicarbonate, aspartate and ammonia are used to make what?
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
Elimination of an amino group
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
Condition when uric acid crystals precipitate out of the blood
This enzyme converts creatine to creatine phosphate.
This molecule activtivates CPS-II
Presence of creatine kinase in the blood can indicate ___________________.
In a healthy person ketovaline is broken down into ______________>
This molecule inhibits CPS-II
ClueAnswer
Creatine phosphate donates its phosphate group to ADP after _________________.
What are uric acid crystals interacting with in gouty arthritis?
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
Lysosomal proteases that degrade protein in the lysosomal pathway
Branched chain ketoacid dehydrogenase requires what cofactor?
What immune cell carries out de novo synthesis of nucleotides?
This type of base is sythesized piece by piece directly on the ribose
This enzyme is deficient in albinism.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
What molecule is at the branch point of de novo purine synthesis?
This isoform of CK is found in the heart and is important in diagnosing MIs.
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
This molecule allosterically activates CPS-I
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
This enzyme converts Argininosuccinate to Arginine and Fumarate.
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
CTP Synthase aminates UTP with an amino group from where?
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
Converts OMP to UMP
This enzyme converts Carbamoyl aspartate to Dihydroorotate
Increased BUN usually indicates ________________ disease.
Enzyme that converts thymidine to TMP
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
Ribose-5-Phostphate is an intermediary in what pathway?
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
PRPP synthase is negatively regulated by ________________
This enzyme converts dihydrofolate to tetrahydrofolate
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
What amino acid is added to IMP to make GMP?
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
Enzyme that transaminates alanine
Normal BUN:Creatinine level is ____________:1
What type of amino acids are not principally oxidized in the liver?
This enzyme converts UTP to CTP
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Deficient enzyme in maple syrup urine disease
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
What is the base in IMP?
20% of SCID cases are due to this enzyme deficiency
Ketogenic amino acids yield which compound(s)?
Homocystinuria results from a deficiency of this enzyme

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein