Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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In a healthy person ketovaline is broken down into ______________>
Most de novo nucleotide synthesis occurs where?
This enzyme converts Argininosuccinate to Arginine and Fumarate.
Converts OMP to UMP
Ezyme that transaminates aspartate
This molecule inhibits thymidine kinase
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
Normal BUN:Creatinine level is ____________:1
A deposit of urate crystals in someone with gout
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
Bicarbonate, aspartate and ammonia are used to make what?
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
What is the base in IMP?
Elimination of an amino group
PRPP synthase is negatively regulated by ________________
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
20% of SCID cases are due to this enzyme deficiency
This enzyme is deficient in histidinemia
What type of amino acids are not principally oxidized in the liver?
Lysosomal proteases that degrade protein in the lysosomal pathway
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
What are uric acid crystals interacting with in gouty arthritis?
This enzyme converts neucleotides to nucleosides
Coverts dihydroorotate to orotate with FAD
Creatine kinase is only made in muscle cells that are _________________.
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
This amino acid is used in the production of melanin
This enzyme converts creatine to creatine phosphate.
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
CTP Synthase aminates UTP with an amino group from where?
A deficiency of this enzyme would be indicated by citrullinemia.
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
________________ cause poor myelination and mental retardation.
What amino acids are purely ketogenic?
This enzyme converts Xanthine to Uric Acid
What substrate is used to synthesize PRPP?
This genetic disease is characterized by self-mutilating behavior
This enzyme catalyzes formation of AMP from adenine and PRPP
What is molecule is 'activated ribose'?
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
People with hyperammonemia are given ________________ so the body uses it for energy of protein
This enzyme converts Carbamoyl aspartate to Dihydroorotate
This enzyme adds an ammonium ion to glutamate to make glutamine
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
This molecule inhibits CPS-II
This type of base is assembled completely first then attached to a ribose
This molecule activtivates CPS-II
Enzyme that transaminates alanine
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
Branched chain ketoacid dehydrogenase requires what cofactor?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
The most effective treatment for SCID
This isoform of CK is found in the heart and is important in diagnosing MIs.
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
What enzyme is deficient in alkaptonuria?
The methyl group needed for the conversion of dUMP to dTMP comes from...
Deamination reactions create this highly toxic chemical that must be removed from the body.
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
What amino acid is added to IMP to make GMP?
Purine nucleosides are converted to free bases by what enzyme?
Presence of creatine kinase in the blood can indicate ___________________.
Creatine phosphate donates its phosphate group to ADP after _________________.
Converts orotate to OMP
This enzyme is deficient in albinism.
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
What immune cell carries out de novo synthesis of nucleotides?
This enzyme converts dihydrofolate to tetrahydrofolate
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
Decreased BUN usually indicates ______________ disease.
CPS-II is most sensitive to PRPP during what cell phase?
Since humans can't store purines we must get rid of them in this form
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
This type of base is sythesized piece by piece directly on the ribose
What amino acid is added to IMP to make AMP?
Enzyme that converts deoyuridine to dUMP
What amino acid donates an amino group to PRPP?
What is the product of the rate limiting step of the urea cycle
What enzyme converts ribonucleotides to deoxyribonucleotides
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Ribose-5-Phostphate is an intermediary in what pathway?
A deficiency of this enzyme would be indicated by Argininemia
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
________________ have a maple/cheesy smell.
Enzyme that converts THF to N5, N10-methylene THF
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Homocystinuria results from a deficiency of this enzyme
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
Glycine, arginine and methionine are used to synthesize what?
In PKU which amino acid becomes essential?
Treatment for Lesch-Nyhan Sydrome?
This enzyme converts hypoxanthine to xanthine
Enzyme that converts thymidine to TMP
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
This molecule allosterically activates CPS-I
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
What enzyme synthesizes PRPP?
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
This enzyme combines citrulline and aspartate to argininosuccinate
Ketogenic amino acids yield which compound(s)?
How is maple syrup urine disease treated?
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
This small, basic protein tags proteins for degradation
This enzyme can convert Adenosine to Inosine
Condition when uric acid crystals precipitate out of the blood
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
The most commonly inherited urea enzyme deficiency
Segments rich in what amino acids are rapidly degraded? (acronym)
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
This is a common cause of acquired hyperammonemia.
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
Deficient enzyme in maple syrup urine disease
Increased BUN usually indicates ________________ disease.
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
Enzyme that converts dUMP to dMP
This enzyme converts UTP to CTP
Phenylpyruvate and phenylacetate are _____________.
If the CK found in the heart is greater than ______ U/L then an MI is probable.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
Deficiency of this enzyme would lead to increased levels of orotic acid
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
What molecule is at the branch point of de novo purine synthesis?
CPS-II is most sensitive to UTP during the end of which cell phase?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
The cofactor required for transamination reaction is a derivative of ______________.
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.

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Created Dec 17, 2012ReportNominate
Tags:biochemistry, nucleotide, protein