Biochemistry: Protein and Nucleotide Metabolism

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Can you name the Biochemistry: Protein and Nucleotide Metabolism?

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ClueAnswer
This molecule activtivates CPS-II
This enzyme removes an ammonium ion from glutamate to make alpha-ketoglutarate.
Decreased BUN usually indicates ______________ disease.
Creatine phosphate 'buffers' ___________ during exercise so it doesn't significantly drop.
The most effective treatment for SCID
A deficiency of this enzyme would be indicated by Argininosuccinic Acidemia
This enzyme adds an ammonium ion to glutamate to make glutamine
This enzyme converts carbomoyl phosphate to carbomoyl aspartate
Increased BUN usually indicates ________________ disease.
Phenylpyruvate and phenylacetate are _____________.
This enzyme converts Xanthine to Uric Acid
Creatine phosphate donates its phosphate group to ADP after _________________.
How is maple syrup urine disease treated?
This enzyme converts 5-phosphoribosyl-1-pyrophosphate to 5-phosphoribosyl-1-amine
Aminotransferase put the amino group from alanine on alpha-ketoglutarate to form glutamate and ___________________.
The methyl group needed for the conversion of dUMP to dTMP comes from...
PRPP synthase is negatively regulated by ________________
CPS-II is most sensitive to UTP during the end of which cell phase?
This disease causes increased levels of histidine in the blood and urine and causes mental retardation
This drug binds to glycine in the liver and is excreted in order to reduce ammonia in the body.
This enzyme converts UTP to CTP
This type of base is sythesized piece by piece directly on the ribose
Ribose-5-Phostphate is an intermediary in what pathway?
Most de novo nucleotide synthesis occurs where?
This enzyme is deficient in albinism.
Ezyme that transaminates aspartate
Enzyme that converts thymidine to TMP
Glycine, arginine and methionine are used to synthesize what?
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily activated
Enzyme that converts THF to N5, N10-methylene THF
Since humans can't store purines we must get rid of them in this form
This enzyme combines citrulline and aspartate to argininosuccinate
What is the base in IMP?
What is molecule is 'activated ribose'?
This single bifunctional enzyme has the properties of orotate phosphotranfserase and OMP decaboxylase
CTP Synthase aminates UTP with an amino group from where?
The cofactor required for transamination reaction is a derivative of ______________.
What immune cell uses primarily the salvage pathway for nucleotide synthesis?
This is a common cause of acquired hyperammonemia.
This enzyme converts Carbamoyl aspartate to Dihydroorotate
This enzyme found in the gut cleaves urea to get carbon dioxide and ammonia.
People with hyperammonemia are given ________________ so the body uses it for energy of protein
Cofactor of all aminotransferase reactions because amino group is first transferred to this molecule.
In a healthy person ketovaline is broken down into ______________>
What amino acids are purely ketogenic?
This metabolite inhibites ribonucleotide reductase leading to the inability of cells to synthesize deoxyribonucleotides and therefore DNA.
Creatine kinase is only made in muscle cells that are _________________.
ClueAnswer
This enzyme phosphorylates CPS-II to change its allosteric properties making it more easily inhibited
Pyrophosphates are the basis of this drug class which is used to treat osteoporosis.
What amino acid is added to IMP to make AMP?
Segments rich in what amino acids are rapidly degraded? (acronym)
This amino acid is used in the production of melanin
This enzyme can convert Adenosine to Inosine
During periods of malnutrition, starvation, cachexia and after traumatic injury the nitrogen balance is _________________.
Converts OMP to UMP
This amino acid has two amino groups and is thus the most efficient carrier of ammonia
Normal BUN:Creatinine level is ____________:1
This transaminase enzyme helps the urea cycle by being involved in the recycling of fumarate to aspartate.
________________ cause poor myelination and mental retardation.
This enzyme converts dihydrofolate to tetrahydrofolate
Lacking OMP decarboxylase or orotate phosphoribosyltransferase causes this rare metabolic condition. Patients often have aneamia, leukopenia and retarded development.
Bicarbonate, aspartate and ammonia are used to make what?
What product builds up in ADA deficient SCID that inhibits deoxynucleotide synthesis
This is the first enzyme to rise following a myocardial infarction and may only rise transiently and normalize in less thatn 3 days.
This small, basic protein tags proteins for degradation
GMP, GDP, GTP, AMP, ADP and ATP all inhibit what enzyme?
What amino acid is added to IMP to make GMP?
One type of this autosomal recessive disease stems from a deficiency of phenylalanine hydroxylase
What molecule is at the branch point of de novo purine synthesis?
What type of amino acids are not principally oxidized in the liver?
Deamination occurs primarily on this amino acid because it is the end produce of many transamination reactions.
Aspartate, Arginine, Leucine, Lysine and Phenylalanine are which type of N-Terminal amino acids?
This isoform of CK is found in the heart and is important in diagnosing MIs.
A deposit of urate crystals in someone with gout
Condition when uric acid crystals precipitate out of the blood
What is the product of the rate limiting step of the urea cycle
A very high protein diet or starvation would lead to __________________ (induction/repression) of urea cycle enzymes.
What substrate is used to synthesize PRPP?
Purine nucleosides are converted to free bases by what enzyme?
20% of SCID cases are due to this enzyme deficiency
What amino acid donates an amino group to PRPP?
Presence of creatine kinase in the blood can indicate ___________________.
What enzyme converts ribonucleotides to deoxyribonucleotides
A deficiency of this enzyme would be indicated by Argininemia
Deficient enzyme in maple syrup urine disease
This enzyme converts neucleotides to nucleosides
The most commonly inherited urea enzyme deficiency
What are uric acid crystals interacting with in gouty arthritis?
With what disease would a patient have high levels of valine, leucine and isoleucine in their blood?
Homocystinuria results from a deficiency of this enzyme
A deficiency of this enzyme would be indicated by citrullinemia.
What enzyme is deficient in alkaptonuria?
What enzyme synthesizes PRPP?
This enzyme catalyzes the formation of IMP and GMP from Hypoxanthine and Guanine and PRPP
ClueAnswer
Deficiency of this enzyme would lead to increased levels of orotic acid
This type of base is assembled completely first then attached to a ribose
The deficient enzyme in alkaptonuria breaks down tyrosine to form _____________.
Coverts dihydroorotate to orotate with FAD
This enzyme converts hypoxanthine to xanthine
In PKU which amino acid becomes essential?
This genetic disease is characterized by self-mutilating behavior
This enzyme is deficient in histidinemia
HGPRT ___________________ causes an increase in the rate of purine synthesis. (Deficiency/Hyperactivity)
Ketogenic amino acids yield which compound(s)?
Converts orotate to OMP
Transfer of an amino group from one amino acid to an amino acid carbon skeleton or alpha ketoacid.
What immune cell carries out de novo synthesis of nucleotides?
A muscle cell that is fully charged with CP has a __________:1 ratio of CP:ATP
During periods of growth, pregnancy and convalescence the nitrogen balance is _________________.
This molecule allosterically activates CPS-I
If the CK found in the heart is greater than ______ U/L then an MI is probable.
CPS-II is most sensitive to PRPP during what cell phase?
This enzyme converts creatine to creatine phosphate.
A genetic mutation in what enzyme can cause increased de novo synthesis of purines and hyperuricemia
Enzyme that converts dUMP to dMP
This enzyme catalyzes the conversion of bicarbonate and ammonia (from glutamine) to carbomoyl phosphate, releasing glutamate.
Lysosomal proteases that degrade protein in the lysosomal pathway
This enzyme combines ornithine and carbamoyl phosphate to make citrulline
Homocystein and methionine levels are increased in this disease that causes mental retardation and dislocation of the lens of the eye.
Treatment for Lesch-Nyhan Sydrome?
What type of reaction can create non-essential amino acids from essential amino acids or non-essential AAs from non-essential AAs.
________________ have a maple/cheesy smell.
In hereditary hyperammonemia the administration or citrulline and arginine is usually effective except in the case of _______________.
Lysosomal degradation activity is ______________ during starvation? (Increased/Decreased)
This molecule inhibits CPS-II
This drug binds to glutamine and is then excreted from the body in order to reduce the ammonia in the body
This isoform of creatine kinase is found in smooth muscle and brain tissue and makes up only 1% of total CK.
The glycine residue at the carboxyl end of ubiquitin attaches to what residue on the target protein?
This enzyme catalyzes formation of AMP from adenine and PRPP
Enzyme that transaminates alanine
Enzyme that converts deoyuridine to dUMP
The commited step of de novo purine synthesis is conversion of PRPP to ____________________.
Branched chain ketoacid dehydrogenase requires what cofactor?
A polymer of this chemical creates a black-brown pigment that deposits in connective tissue and can be seen in standing urine in people with alkoptonuria.
A genetic mutation leading to a deficiency in HGPRT leads to what condition?
Deamination reactions create this highly toxic chemical that must be removed from the body.
Alanine, glycine, methionine, serine, threonine and valine are which type of N-terminal residues?
This enzyme converts Argininosuccinate to Arginine and Fumarate.
This molecule inhibits thymidine kinase
Elimination of an amino group
This isoform of creatine kinase is in skeletal muscle and makes up 95% of the CK in the body.

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