Just For Fun / MDTI - ALL OF RHEUMATOLOGY

Random Just For Fun Quiz

Can you name the MDTI - ALL OF RHEUMATOLOGY?

Quiz not verified by Sporcle

Forced Order
Challenge
Share
Tweet
Embed
PromptsDiseases
TGFb/CTGF sensitize fibroblasts and increases collagen production
>50,000 cells, >95% PMN's
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Type I/III collagen production
cells inappropriately express both MHC1 and 2
ANA test involves permeabilizing cells
Cytokines: IL-6, IL-17, IFN-alpha
Raynaud's Phenomenon precedes it
environmental influence of vinyl plastics, hair dyes
problems in the WNT pathway
treat with physical therapy, braces, NSAIDs
4:1 female to male ratio
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
cast nephritis
30% associated with HepB infection
HLA DQ7/DR5 associated
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
increase vascularization of cartilage which allows cytokine spread
Blys
polymorphisms in C2/C4 genes
osteophytes
fibroblasts turn to myofibroblasts
cartilage fragments mediate inflammation
Interferon Signature (1)
Oxypurinol
estrogen and prolactin cause activation/proliferation of lymphocytes
Febuxostat
Anti-SCl-70 (Topoisomerase 1)
Comes in both diffuse/limited versions
ectopic lymphoid follicles in salivary glands
lack of DHEA
Genetic defect in COL1A2, TGFb, Fibrillin 1
Vital Dye test
environmental triggers are UV exposure/DNA or RNA viruses/Medication
anti-ANA are first important sign
cytoplasmic and perinuclear antibodies
TGFb/SMAD signaling
Belimumab (2)
discoid rash
Defect in clearance of apoptosis
PromptsDiseases
NALP3
Can be caused by increase in enzyme APRT
Heberden's Node
URAT1
cells express Bax, lymphocytes express BCLxl
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Anti-centromere antibodies seen in limited version
cholinesterase
6% concordance among MZ twins
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
Fibrosis leading to ischemia and organ damage
fibrillations
Probenecid
fibrinoid kidney necrosis causes hypertension
Mainly affects DIP, Knee, and 1st MCP joints
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Possible mimicry between retroviruses and anti-SCL70
CXCL 13 - B-cells
20-200 white cells in joint fluid
3 stages, last one develops B cell Lymphoma
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
IFN-g/TNFa both inhibit SMAD activity
focus
fibroblasts upregulate PDGFr in response to TGFb
Can be caused by increase in enzyme XO
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
transmural inflammation
Uric Acid Kidney Stones
Sex hormones/chromosomes are important
treat acute flair up with NSAIDs, colchicine, corticosteroids
Vascular injury may be initiating factor
40% twin concordance
CXCL 12 - T-cells
polymorphisms in HLA DR2/DR3
anti-ssa/ssb (not lupus)
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
Allopurinol
TGFb downregulated metalloproteinase release
PromptsDiseases
sicca
early, early disseminated, late disseminated spread
interferon signature connects viral infection to lymphocyte invasion
IFN signal induced by DNA/RNA containing complexes
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
Defect in Complement Receptor 1, FCyR
Can be caused by increase in enzyme PRPP
crescentic glomerulonephritis
Anti-Smith, Anti-dsDNA, Anti-SSB
hypertrophy of chondrocytes, but decrease in collagen production
cytokines: TGFb, CTGF, PDGF(r)
Inflammasomes
Schirmer's test
Bouchard's Node
Belimumab (1)
75% of people get this
A20 mutation leads to too much NfKb
2000-100,000 white cells in joint fluid
Tophi in olecranon bursa
two causal reasons: highly vascularized synovium, no basement membrane
African Americans have particularly high anti-SCL70, bad prognosis
90% male, correlated with obesity and alcohol use
spares lung/kidneys
anti-M3
BAFF
subchondral sclerosis
malar rash
slow progression over time
Interferon Signature (2)
karryohexis
Can be caused by deficiency of HGPRT
CREST
renal hypertension due to medium vessel closure
lymphepithelial lesion
HLADRB1 association
msu crystals
cppd
sialadenitis
200-2000 white cells in joint fluid

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
OR
Log In

You Might Also Like...

Show Comments

Extras


Your Account Isn't Verified!

In order to create a playlist on Sporcle, you need to verify the email address you used during registration. Go to your Sporcle Settings to finish the process.