MDTI - ALL OF RHEUMATOLOGY

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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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PromptsDiseases
Can be caused by increase in enzyme XO
Vascular injury may be initiating factor
HLA DQ7/DR5 associated
CREST
cytoplasmic and perinuclear antibodies
estrogen and prolactin cause activation/proliferation of lymphocytes
BAFF
lack of DHEA
Raynaud's Phenomenon precedes it
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
200-2000 white cells in joint fluid
fibroblasts upregulate PDGFr in response to TGFb
discoid rash
hypertrophy of chondrocytes, but decrease in collagen production
Uric Acid Kidney Stones
Blys
polymorphisms in HLA DR2/DR3
Oxypurinol
lymphepithelial lesion
HLADRB1 association
TGFb downregulated metalloproteinase release
treat with physical therapy, braces, NSAIDs
spares lung/kidneys
slow progression over time
Sex hormones/chromosomes are important
focus
Cytokines: IL-6, IL-17, IFN-alpha
Possible mimicry between retroviruses and anti-SCL70
75% of people get this
sicca
subchondral sclerosis
A20 mutation leads to too much NfKb
Defect in Complement Receptor 1, FCyR
msu crystals
ectopic lymphoid follicles in salivary glands
cast nephritis
cytokines: TGFb, CTGF, PDGF(r)
Anti-SCl-70 (Topoisomerase 1)
TGFb/SMAD signaling
fibrinoid kidney necrosis causes hypertension
PromptsDiseases
CXCL 12 - T-cells
Vital Dye test
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
TGFb/CTGF sensitize fibroblasts and increases collagen production
crescentic glomerulonephritis
sialadenitis
two causal reasons: highly vascularized synovium, no basement membrane
NALP3
URAT1
karryohexis
fibroblasts turn to myofibroblasts
anti-ANA are first important sign
Bouchard's Node
Interferon Signature (1)
>50,000 cells, >95% PMN's
anti-ssa/ssb (not lupus)
Defect in clearance of apoptosis
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Can be caused by increase in enzyme PRPP
20-200 white cells in joint fluid
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Type I/III collagen production
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
renal hypertension due to medium vessel closure
malar rash
6% concordance among MZ twins
Can be caused by increase in enzyme APRT
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
cppd
transmural inflammation
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
IFN-g/TNFa both inhibit SMAD activity
cells express Bax, lymphocytes express BCLxl
Tophi in olecranon bursa
Mainly affects DIP, Knee, and 1st MCP joints
CXCL 13 - B-cells
Belimumab (1)
African Americans have particularly high anti-SCL70, bad prognosis
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
PromptsDiseases
anti-M3
cholinesterase
4:1 female to male ratio
osteophytes
early, early disseminated, late disseminated spread
3 stages, last one develops B cell Lymphoma
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Genetic defect in COL1A2, TGFb, Fibrillin 1
polymorphisms in C2/C4 genes
cells inappropriately express both MHC1 and 2
Comes in both diffuse/limited versions
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Anti-Smith, Anti-dsDNA, Anti-SSB
increase vascularization of cartilage which allows cytokine spread
2000-100,000 white cells in joint fluid
30% associated with HepB infection
environmental triggers are UV exposure/DNA or RNA viruses/Medication
Fibrosis leading to ischemia and organ damage
ANA test involves permeabilizing cells
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
interferon signature connects viral infection to lymphocyte invasion
Allopurinol
problems in the WNT pathway
Febuxostat
fibrillations
Schirmer's test
90% male, correlated with obesity and alcohol use
IFN signal induced by DNA/RNA containing complexes
40% twin concordance
treat acute flair up with NSAIDs, colchicine, corticosteroids
Belimumab (2)
Interferon Signature (2)
cartilage fragments mediate inflammation
Anti-centromere antibodies seen in limited version
Inflammasomes
Heberden's Node
environmental influence of vinyl plastics, hair dyes
Can be caused by deficiency of HGPRT
Probenecid

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt