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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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Can be caused by deficiency of HGPRT
treat with physical therapy, braces, NSAIDs
Interferon Signature (2)
crescentic glomerulonephritis
discoid rash
ectopic lymphoid follicles in salivary glands
problems in the WNT pathway
cells inappropriately express both MHC1 and 2
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
IFN-g/TNFa both inhibit SMAD activity
2000-100,000 white cells in joint fluid
Tophi in olecranon bursa
fibroblasts upregulate PDGFr in response to TGFb
cast nephritis
environmental triggers are UV exposure/DNA or RNA viruses/Medication
90% male, correlated with obesity and alcohol use
Belimumab (2)
20-200 white cells in joint fluid
estrogen and prolactin cause activation/proliferation of lymphocytes
msu crystals
Can be caused by increase in enzyme XO
TGFb/CTGF sensitize fibroblasts and increases collagen production
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
Raynaud's Phenomenon precedes it
Anti-centromere antibodies seen in limited version
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
TGFb downregulated metalloproteinase release
anti-ANA are first important sign
CXCL 12 - T-cells
polymorphisms in C2/C4 genes
polymorphisms in HLA DR2/DR3
Mainly affects DIP, Knee, and 1st MCP joints
Can be caused by increase in enzyme APRT
75% of people get this
Anti-SCl-70 (Topoisomerase 1)
increase vascularization of cartilage which allows cytokine spread
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Schirmer's test
Defect in clearance of apoptosis
slow progression over time
Interferon Signature (1)
Uric Acid Kidney Stones
cells express Bax, lymphocytes express BCLxl
early, early disseminated, late disseminated spread
3 stages, last one develops B cell Lymphoma
>50,000 cells, >95% PMN's
4:1 female to male ratio
Type I/III collagen production
environmental influence of vinyl plastics, hair dyes
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
fibroblasts turn to myofibroblasts
two causal reasons: highly vascularized synovium, no basement membrane
Can be caused by increase in enzyme PRPP
Belimumab (1)
hypertrophy of chondrocytes, but decrease in collagen production
Anti-Smith, Anti-dsDNA, Anti-SSB
Characterized by immune dysregulation/vascular dysfunction/fibrosis
30% associated with HepB infection
ANA test involves permeabilizing cells
anti-ssa/ssb (not lupus)
Sex hormones/chromosomes are important
transmural inflammation
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
cytokines: TGFb, CTGF, PDGF(r)
treat acute flair up with NSAIDs, colchicine, corticosteroids
TGFb/SMAD signaling
IFN signal induced by DNA/RNA containing complexes
Heberden's Node
200-2000 white cells in joint fluid
lack of DHEA
fibrinoid kidney necrosis causes hypertension
cytoplasmic and perinuclear antibodies
interferon signature connects viral infection to lymphocyte invasion
Genetic defect in COL1A2, TGFb, Fibrillin 1
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Vital Dye test
CXCL 13 - B-cells
HLA DQ7/DR5 associated
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
malar rash
Defect in Complement Receptor 1, FCyR
Cytokines: IL-6, IL-17, IFN-alpha
Comes in both diffuse/limited versions
Bouchard's Node
HLADRB1 association
Fibrosis leading to ischemia and organ damage
subchondral sclerosis
African Americans have particularly high anti-SCL70, bad prognosis
A20 mutation leads to too much NfKb
Vascular injury may be initiating factor
lymphepithelial lesion
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
spares lung/kidneys
40% twin concordance
cartilage fragments mediate inflammation
Possible mimicry between retroviruses and anti-SCL70
renal hypertension due to medium vessel closure
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
6% concordance among MZ twins

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt