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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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monoarthritic arthritis, usually 1st MTP/Knee/Ankle
TGFb/CTGF sensitize fibroblasts and increases collagen production
Can be caused by increase in enzyme XO
4:1 female to male ratio
Tophi in olecranon bursa
interferon signature connects viral infection to lymphocyte invasion
transmural inflammation
Vital Dye test
spares lung/kidneys
Vascular injury may be initiating factor
environmental influence of vinyl plastics, hair dyes
cartilage fragments mediate inflammation
lack of DHEA
malar rash
Mainly affects DIP, Knee, and 1st MCP joints
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
anti-ANA are first important sign
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
treat acute flair up with NSAIDs, colchicine, corticosteroids
Belimumab (1)
hypertrophy of chondrocytes, but decrease in collagen production
Cytokines: IL-6, IL-17, IFN-alpha
>50,000 cells, >95% PMN's
cells inappropriately express both MHC1 and 2
polymorphisms in HLA DR2/DR3
Can be caused by increase in enzyme PRPP
Anti-SCl-70 (Topoisomerase 1)
cells express Bax, lymphocytes express BCLxl
Defect in clearance of apoptosis
Can be caused by deficiency of HGPRT
200-2000 white cells in joint fluid
polymorphisms in C2/C4 genes
A20 mutation leads to too much NfKb
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
90% male, correlated with obesity and alcohol use
anti-ssa/ssb (not lupus)
Type I/III collagen production
Uric Acid Kidney Stones
discoid rash
fibrinoid kidney necrosis causes hypertension
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
Raynaud's Phenomenon precedes it
Characterized by immune dysregulation/vascular dysfunction/fibrosis
lymphepithelial lesion
ANA test involves permeabilizing cells
African Americans have particularly high anti-SCL70, bad prognosis
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
msu crystals
Can be caused by increase in enzyme APRT
estrogen and prolactin cause activation/proliferation of lymphocytes
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
HLA DQ7/DR5 associated
75% of people get this
IFN signal induced by DNA/RNA containing complexes
fibroblasts turn to myofibroblasts
crescentic glomerulonephritis
20-200 white cells in joint fluid
Possible mimicry between retroviruses and anti-SCL70
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
Anti-Smith, Anti-dsDNA, Anti-SSB
Genetic defect in COL1A2, TGFb, Fibrillin 1
40% twin concordance
slow progression over time
Sex hormones/chromosomes are important
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
2000-100,000 white cells in joint fluid
Schirmer's test
TGFb/SMAD signaling
fibroblasts upregulate PDGFr in response to TGFb
Belimumab (2)
subchondral sclerosis
environmental triggers are UV exposure/DNA or RNA viruses/Medication
Heberden's Node
HLADRB1 association
cast nephritis
problems in the WNT pathway
Anti-centromere antibodies seen in limited version
Interferon Signature (2)
ectopic lymphoid follicles in salivary glands
Comes in both diffuse/limited versions
increase vascularization of cartilage which allows cytokine spread
Interferon Signature (1)
two causal reasons: highly vascularized synovium, no basement membrane
30% associated with HepB infection
treat with physical therapy, braces, NSAIDs
Bouchard's Node
TGFb downregulated metalloproteinase release
Defect in Complement Receptor 1, FCyR
6% concordance among MZ twins
CXCL 12 - T-cells
early, early disseminated, late disseminated spread
IFN-g/TNFa both inhibit SMAD activity
cytokines: TGFb, CTGF, PDGF(r)
Fibrosis leading to ischemia and organ damage
cytoplasmic and perinuclear antibodies
CXCL 13 - B-cells
3 stages, last one develops B cell Lymphoma
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
renal hypertension due to medium vessel closure

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt