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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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increase vascularization of cartilage which allows cytokine spread
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Anti-SCl-70 (Topoisomerase 1)
TGFb/SMAD signaling
30% associated with HepB infection
90% male, correlated with obesity and alcohol use
Can be caused by increase in enzyme XO
Characterized by immune dysregulation/vascular dysfunction/fibrosis
malar rash
Schirmer's test
slow progression over time
Can be caused by increase in enzyme PRPP
A20 mutation leads to too much NfKb
interferon signature connects viral infection to lymphocyte invasion
Defect in Complement Receptor 1, FCyR
cytoplasmic and perinuclear antibodies
cells inappropriately express both MHC1 and 2
lack of DHEA
ectopic lymphoid follicles in salivary glands
Tophi in olecranon bursa
subchondral sclerosis
anti-ANA are first important sign
cells express Bax, lymphocytes express BCLxl
spares lung/kidneys
environmental influence of vinyl plastics, hair dyes
Interferon Signature (1)
Comes in both diffuse/limited versions
Mainly affects DIP, Knee, and 1st MCP joints
Anti-centromere antibodies seen in limited version
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
treat with physical therapy, braces, NSAIDs
msu crystals
Vascular injury may be initiating factor
Genetic defect in COL1A2, TGFb, Fibrillin 1
Sex hormones/chromosomes are important
>50,000 cells, >95% PMN's
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
Can be caused by deficiency of HGPRT
Heberden's Node
cartilage fragments mediate inflammation
polymorphisms in HLA DR2/DR3
renal hypertension due to medium vessel closure
Anti-Smith, Anti-dsDNA, Anti-SSB
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Belimumab (1)
IFN signal induced by DNA/RNA containing complexes
African Americans have particularly high anti-SCL70, bad prognosis
environmental triggers are UV exposure/DNA or RNA viruses/Medication
20-200 white cells in joint fluid
TGFb/CTGF sensitize fibroblasts and increases collagen production
Uric Acid Kidney Stones
200-2000 white cells in joint fluid
polymorphisms in C2/C4 genes
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
6% concordance among MZ twins
early, early disseminated, late disseminated spread
HLADRB1 association
Belimumab (2)
Interferon Signature (2)
transmural inflammation
4:1 female to male ratio
IFN-g/TNFa both inhibit SMAD activity
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
CXCL 12 - T-cells
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
75% of people get this
problems in the WNT pathway
Type I/III collagen production
fibroblasts turn to myofibroblasts
fibroblasts upregulate PDGFr in response to TGFb
Can be caused by increase in enzyme APRT
2000-100,000 white cells in joint fluid
cytokines: TGFb, CTGF, PDGF(r)
crescentic glomerulonephritis
CXCL 13 - B-cells
estrogen and prolactin cause activation/proliferation of lymphocytes
hypertrophy of chondrocytes, but decrease in collagen production
Bouchard's Node
TGFb downregulated metalloproteinase release
anti-ssa/ssb (not lupus)
fibrinoid kidney necrosis causes hypertension
HLA DQ7/DR5 associated
discoid rash
treat acute flair up with NSAIDs, colchicine, corticosteroids
Raynaud's Phenomenon precedes it
lymphepithelial lesion
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
3 stages, last one develops B cell Lymphoma
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
Possible mimicry between retroviruses and anti-SCL70
Fibrosis leading to ischemia and organ damage
two causal reasons: highly vascularized synovium, no basement membrane
Defect in clearance of apoptosis
ANA test involves permeabilizing cells
cast nephritis
Cytokines: IL-6, IL-17, IFN-alpha
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
40% twin concordance
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Vital Dye test

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt