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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Can be caused by increase in enzyme APRT
CXCL 13 - B-cells
Anti-Smith, Anti-dsDNA, Anti-SSB
fibroblasts turn to myofibroblasts
>50,000 cells, >95% PMN's
Can be caused by increase in enzyme PRPP
Vascular injury may be initiating factor
transmural inflammation
6% concordance among MZ twins
Belimumab (1)
90% male, correlated with obesity and alcohol use
estrogen and prolactin cause activation/proliferation of lymphocytes
A20 mutation leads to too much NfKb
cytoplasmic and perinuclear antibodies
polymorphisms in HLA DR2/DR3
75% of people get this
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
fibrinoid kidney necrosis causes hypertension
Heberden's Node
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
HLADRB1 association
African Americans have particularly high anti-SCL70, bad prognosis
increase vascularization of cartilage which allows cytokine spread
cells express Bax, lymphocytes express BCLxl
anti-ANA are first important sign
HLA DQ7/DR5 associated
subchondral sclerosis
200-2000 white cells in joint fluid
CXCL 12 - T-cells
cast nephritis
Can be caused by increase in enzyme XO
ectopic lymphoid follicles in salivary glands
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
treat with physical therapy, braces, NSAIDs
Characterized by immune dysregulation/vascular dysfunction/fibrosis
TGFb/SMAD signaling
Mainly affects DIP, Knee, and 1st MCP joints
anti-ssa/ssb (not lupus)
TGFb/CTGF sensitize fibroblasts and increases collagen production
renal hypertension due to medium vessel closure
IFN-g/TNFa both inhibit SMAD activity
Schirmer's test
30% associated with HepB infection
3 stages, last one develops B cell Lymphoma
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Anti-SCl-70 (Topoisomerase 1)
cartilage fragments mediate inflammation
Genetic defect in COL1A2, TGFb, Fibrillin 1
lymphepithelial lesion
environmental triggers are UV exposure/DNA or RNA viruses/Medication
Vital Dye test
msu crystals
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
2000-100,000 white cells in joint fluid
TGFb downregulated metalloproteinase release
Fibrosis leading to ischemia and organ damage
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
ANA test involves permeabilizing cells
Can be caused by deficiency of HGPRT
Raynaud's Phenomenon precedes it
environmental influence of vinyl plastics, hair dyes
cytokines: TGFb, CTGF, PDGF(r)
40% twin concordance
spares lung/kidneys
treat acute flair up with NSAIDs, colchicine, corticosteroids
Anti-centromere antibodies seen in limited version
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
4:1 female to male ratio
problems in the WNT pathway
Tophi in olecranon bursa
Belimumab (2)
discoid rash
two causal reasons: highly vascularized synovium, no basement membrane
20-200 white cells in joint fluid
interferon signature connects viral infection to lymphocyte invasion
Comes in both diffuse/limited versions
fibroblasts upregulate PDGFr in response to TGFb
malar rash
slow progression over time
Interferon Signature (1)
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
Defect in Complement Receptor 1, FCyR
Type I/III collagen production
hypertrophy of chondrocytes, but decrease in collagen production
Uric Acid Kidney Stones
Sex hormones/chromosomes are important
polymorphisms in C2/C4 genes
IFN signal induced by DNA/RNA containing complexes
crescentic glomerulonephritis
Bouchard's Node
cells inappropriately express both MHC1 and 2
early, early disseminated, late disseminated spread
Interferon Signature (2)
lack of DHEA
Defect in clearance of apoptosis
Possible mimicry between retroviruses and anti-SCL70
Cytokines: IL-6, IL-17, IFN-alpha

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt