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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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Genetic defect in COL1A2, TGFb, Fibrillin 1
fibroblasts upregulate PDGFr in response to TGFb
interferon signature connects viral infection to lymphocyte invasion
20-200 white cells in joint fluid
Anti-centromere antibodies seen in limited version
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
msu crystals
Interferon Signature (1)
Interferon Signature (2)
increase vascularization of cartilage which allows cytokine spread
Can be caused by increase in enzyme APRT
renal hypertension due to medium vessel closure
cells inappropriately express both MHC1 and 2
Mainly affects DIP, Knee, and 1st MCP joints
4:1 female to male ratio
A20 mutation leads to too much NfKb
malar rash
fibroblasts turn to myofibroblasts
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
anti-ssa/ssb (not lupus)
Belimumab (2)
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
Characterized by immune dysregulation/vascular dysfunction/fibrosis
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
Anti-SCl-70 (Topoisomerase 1)
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
Sex hormones/chromosomes are important
IFN-g/TNFa both inhibit SMAD activity
Raynaud's Phenomenon precedes it
African Americans have particularly high anti-SCL70, bad prognosis
CXCL 12 - T-cells
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
Bouchard's Node
Can be caused by deficiency of HGPRT
two causal reasons: highly vascularized synovium, no basement membrane
polymorphisms in HLA DR2/DR3
Schirmer's test
spares lung/kidneys
Can be caused by increase in enzyme PRPP
Defect in Complement Receptor 1, FCyR
75% of people get this
discoid rash
ANA test involves permeabilizing cells
Fibrosis leading to ischemia and organ damage
3 stages, last one develops B cell Lymphoma
environmental triggers are UV exposure/DNA or RNA viruses/Medication
cytoplasmic and perinuclear antibodies
Type I/III collagen production
Cytokines: IL-6, IL-17, IFN-alpha
Vascular injury may be initiating factor
HLADRB1 association
30% associated with HepB infection
cartilage fragments mediate inflammation
anti-ANA are first important sign
ectopic lymphoid follicles in salivary glands
Tophi in olecranon bursa
lack of DHEA
Belimumab (1)
Vital Dye test
TGFb downregulated metalloproteinase release
treat with physical therapy, braces, NSAIDs
IFN signal induced by DNA/RNA containing complexes
treat acute flair up with NSAIDs, colchicine, corticosteroids
CXCL 13 - B-cells
cast nephritis
Can be caused by increase in enzyme XO
40% twin concordance
>50,000 cells, >95% PMN's
crescentic glomerulonephritis
hypertrophy of chondrocytes, but decrease in collagen production
200-2000 white cells in joint fluid
polymorphisms in C2/C4 genes
Heberden's Node
subchondral sclerosis
environmental influence of vinyl plastics, hair dyes
lymphepithelial lesion
fibrinoid kidney necrosis causes hypertension
Anti-Smith, Anti-dsDNA, Anti-SSB
cells express Bax, lymphocytes express BCLxl
estrogen and prolactin cause activation/proliferation of lymphocytes
90% male, correlated with obesity and alcohol use
Comes in both diffuse/limited versions
TGFb/CTGF sensitize fibroblasts and increases collagen production
HLA DQ7/DR5 associated
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
problems in the WNT pathway
TGFb/SMAD signaling
cytokines: TGFb, CTGF, PDGF(r)
early, early disseminated, late disseminated spread
2000-100,000 white cells in joint fluid
Uric Acid Kidney Stones
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
Possible mimicry between retroviruses and anti-SCL70
Defect in clearance of apoptosis
transmural inflammation
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
slow progression over time
6% concordance among MZ twins
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt