| Prompts | Diseases |
|---|
| fibroblasts upregulate PDGFr in response to TGFb | |
| cells express Bax, lymphocytes express BCLxl | |
| ectopic lymphoid follicles in salivary glands | |
| 40% twin concordance | |
| 75% of people get this | |
| interferon signature connects viral infection to lymphocyte invasion | |
| Interferon Signature (2) | |
| treat with physical therapy, braces, NSAIDs | |
| NALP3 | |
| Anti-centromere antibodies seen in limited version | |
| polymorphisms in HLA DR2/DR3 | |
| Cytokines: IL-6, IL-17, IFN-alpha | |
| lack of DHEA | |
| CXCL 13 - B-cells | |
| Defect in Complement Receptor 1, FCyR | |
| 2000-100,000 white cells in joint fluid | |
| Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils | |
| renal hypertension due to medium vessel closure | |
| cytokines: TGFb, CTGF, PDGF(r) | |
| Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss | |
| Can be caused by increase in enzyme APRT | |
| two causal reasons: highly vascularized synovium, no basement membrane | |
| 6% concordance among MZ twins | |
| fibrinoid kidney necrosis causes hypertension | |
| Allopurinol | |
| Probenecid | |
| Mainly affects DIP, Knee, and 1st MCP joints | |
| Can be caused by increase in enzyme XO | |
| IFN signal induced by DNA/RNA containing complexes | |
| 4:1 female to male ratio | |
| 20-200 white cells in joint fluid | |
| cells inappropriately express both MHC1 and 2 | |
| fibroblasts turn to myofibroblasts | |
| associated with previous damage (RA, OA), diabetes mellitus, immunosuppression | |
| treat acute flair up with NSAIDs, colchicine, corticosteroids | |
| Anti-SCl-70 (Topoisomerase 1) | |
| Belimumab (1) | |
| cholinesterase | |
| karryohexis | |
| Pyrazinamide, Nicotinate, Lactate all stimulate URAT1 | |
| | Prompts | Diseases |
|---|
| lymphepithelial lesion | |
| Raynaud's Phenomenon precedes it | |
| Uric Acid Kidney Stones | |
| CREST | |
| Tophi in olecranon bursa | |
| polymorphisms in C2/C4 genes | |
| Vascular injury may be initiating factor | |
| Genetic defect in COL1A2, TGFb, Fibrillin 1 | |
| subchondral sclerosis | |
| IFN-g/TNFa both inhibit SMAD activity | |
| 200-2000 white cells in joint fluid | |
| environmental influence of vinyl plastics, hair dyes | |
| ANA test involves permeabilizing cells | |
| Vital Dye test | |
| Heberden's Node | |
| Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues | |
| Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha | |
| Belimumab (2) | |
| Interferon Signature (1) | |
| Can be caused by increase in enzyme PRPP | |
| transmural inflammation | |
| Can be caused by deficiency of HGPRT | |
| Schirmer's test | |
| IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes | |
| TGFb/CTGF sensitize fibroblasts and increases collagen production | |
| Oxypurinol | |
| Bouchard's Node | |
| HLA DQ7/DR5 associated | |
| cartilage fragments mediate inflammation | |
| Type I/III collagen production | |
| malar rash | |
| CXCL 12 - T-cells | |
| msu crystals | |
| sialadenitis | |
| antibiotic resistant arthritis possibly due to mimcry between OspA and LFA | |
| A20 mutation leads to too much NfKb | |
| Characterized by immune dysregulation/vascular dysfunction/fibrosis | |
| early, early disseminated, late disseminated spread | |
| monoarthritic arthritis, usually 1st MTP/Knee/Ankle | |
| Possible mimicry between retroviruses and anti-SCL70 | |
| | Prompts | Diseases |
|---|
| cppd | |
| anti-ANA are first important sign | |
| BAFF | |
| discoid rash | |
| anti-ssa/ssb (not lupus) | |
| hypertrophy of chondrocytes, but decrease in collagen production | |
| estrogen and prolactin cause activation/proliferation of lymphocytes | |
| problems in the WNT pathway | |
| Comes in both diffuse/limited versions | |
| Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1 | |
| TGFb downregulated metalloproteinase release | |
| 30% associated with HepB infection | |
| osteophytes | |
| >50,000 cells, >95% PMN's | |
| fibrillations | |
| URAT1 | |
| Sex hormones/chromosomes are important | |
| Fibrosis leading to ischemia and organ damage | |
| Defect in clearance of apoptosis | |
| Febuxostat | |
| 3 stages, last one develops B cell Lymphoma | |
| environmental triggers are UV exposure/DNA or RNA viruses/Medication | |
| TGFb/SMAD signaling | |
| Inflammasomes | |
| Blys | |
| sicca | |
| cast nephritis | |
| anti-M3 | |
| cytoplasmic and perinuclear antibodies | |
| increase vascularization of cartilage which allows cytokine spread | |
| spares lung/kidneys | |
| 90% male, correlated with obesity and alcohol use | |
| African Americans have particularly high anti-SCL70, bad prognosis | |
| Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs) | |
| slow progression over time | |
| crescentic glomerulonephritis | |
| HLADRB1 association | |
| Anti-Smith, Anti-dsDNA, Anti-SSB | |
| focus | |
|
Colors of the Rainbow
1-100
Drawing a Blank
