MDTI - ALL OF RHEUMATOLOGY

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Can you name the MDTI - ALL OF RHEUMATOLOGY?

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PromptsDiseases
30% associated with HepB infection
two causal reasons: highly vascularized synovium, no basement membrane
6% concordance among MZ twins
Mainly affects DIP, Knee, and 1st MCP joints
Heberden's Node
subchondral sclerosis
75% of people get this
Blys
Can be caused by increase in enzyme XO
Occurrence linked to ingestion of purine/pyrimidines, endogenous production of urate, and breakdown of tissues
Can be caused by deficiency of HGPRT
Vital Dye test
Comes in both diffuse/limited versions
Cytokines: IL-6, IL-17, IFN-alpha
Characterized by immune dysregulation/vascular dysfunction/fibrosis
IFN-g/TNFa both inhibit SMAD activity
msu crystals
monoarthritic arthritis, usually 1st MTP/Knee/Ankle
fibroblasts upregulate PDGFr in response to TGFb
3 stages, last one develops B cell Lymphoma
Acute Uric Acid nephropathy (especially in cancer patients with chemo drugs)
HLADRB1 association
fibroblasts turn to myofibroblasts
Belimumab (1)
Belimumab (2)
associated with previous damage (RA, OA), diabetes mellitus, immunosuppression
Oxypurinol
TGFb/CTGF sensitize fibroblasts and increases collagen production
problems in the WNT pathway
Defect in clearance of apoptosis
treat acute flair up with NSAIDs, colchicine, corticosteroids
antibiotic resistant arthritis possibly due to mimcry between OspA and LFA
Anti-SCl-70 (Topoisomerase 1)
lymphepithelial lesion
Pyrazinamide, Nicotinate, Lactate all stimulate URAT1
fibrillations
increase vascularization of cartilage which allows cytokine spread
Genetic defect in COL1A2, TGFb, Fibrillin 1
Probenecid
IFN signal induced by DNA/RNA containing complexes
PromptsDiseases
crescentic glomerulonephritis
CXCL 13 - B-cells
A20 mutation leads to too much NfKb
environmental triggers are UV exposure/DNA or RNA viruses/Medication
NALP3
BAFF
malar rash
2000-100,000 white cells in joint fluid
sicca
polymorphisms in C2/C4 genes
fibrinoid kidney necrosis causes hypertension
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha
cells express Bax, lymphocytes express BCLxl
renal hypertension due to medium vessel closure
environmental influence of vinyl plastics, hair dyes
Alcohol increases conversion of ATP to AMP; produces lactate that acts on URAT1
cytoplasmic and perinuclear antibodies
Fibrosis leading to ischemia and organ damage
anti-M3
Defect in Complement Receptor 1, FCyR
Allopurinol
discoid rash
interferon signature connects viral infection to lymphocyte invasion
focus
90% male, correlated with obesity and alcohol use
anti-ssa/ssb (not lupus)
osteophytes
Uric Acid Kidney Stones
Anti-centromere antibodies seen in limited version
Can be caused by increase in enzyme PRPP
transmural inflammation
20-200 white cells in joint fluid
sialadenitis
treat with physical therapy, braces, NSAIDs
HLA DQ7/DR5 associated
cytokines: TGFb, CTGF, PDGF(r)
Febuxostat
cppd
karryohexis
Vascular injury may be initiating factor
PromptsDiseases
early, early disseminated, late disseminated spread
African Americans have particularly high anti-SCL70, bad prognosis
Schirmer's test
polymorphisms in HLA DR2/DR3
Interferon Signature (2)
Tophi in olecranon bursa
Interferon Signature (1)
>50,000 cells, >95% PMN's
TGFb downregulated metalloproteinase release
CXCL 12 - T-cells
200-2000 white cells in joint fluid
Raynaud's Phenomenon precedes it
Type I/III collagen production
cells inappropriately express both MHC1 and 2
Pathway: Nalp3 -> IL-1b -> NfkB -> attracting of neutrophils
ANA test involves permeabilizing cells
anti-ANA are first important sign
cartilage fragments mediate inflammation
40% twin concordance
Can be caused by increase in enzyme APRT
slow progression over time
URAT1
cholinesterase
Bouchard's Node
spares lung/kidneys
Sex hormones/chromosomes are important
Anti-Smith, Anti-dsDNA, Anti-SSB
CREST
cast nephritis
hypertrophy of chondrocytes, but decrease in collagen production
Inflammasomes
Possible mimicry between retroviruses and anti-SCL70
IFNalpha upregulates TLR7/IRF7 to help uptake of DNA/RNA containing complexes
TGFb/SMAD signaling
ectopic lymphoid follicles in salivary glands
4:1 female to male ratio
estrogen and prolactin cause activation/proliferation of lymphocytes
Cytokines Involved: IL-1, IL-6, IL-17, TNFalpha, with TNF-alpha being the boss
lack of DHEA

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Created Feb 5, 2012ReportNominate
Tags:disease, prompt