MDTI - Dale Frank Lectures

Random Science or NHL Quiz

Can you name the MDTI NHL buzzwords?

Quiz not verified by Sporcle

How to Play
can evolve or start de novo
Ki67 100%
mott cells
most common leukemia in adults
t(8;14) cMYC translocation
t(11:18) common/ also t(1:14) and t(14:18)
extranodal involvement uncommon
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
flame cell
30-50% transform to DLBCL
10% undergo Richter's transformation
peripheral blood involvement very common
10-15% get AIHA caused by benign cells
plasma cells account for 10% of cellularity
multifocal, destroys bone
MUM1 (IRF4), BCL6, BCL10 positive
hypovolemia due to hypercalcemia
50% IgG, 25% IgA
three separate diseases: nodal, extranodal, splenic
pleiomorphic and heterogenous, difficult to predict behavior
renal failure (casting) due to paraprotein
morphology (centroblastic/immunoblastic) not important
fish-flesh appearance
severe immunodeficiency due to paraprotein
deletion 13q/11q/trisomy 12/17p
extreme paraprotein production
spread quickly to other mucosal sites but may be treated with antibiotics early
two main types: germinal center or activated b cell
aggressive extranodal with CNS involvement
marrow replacement leads to severe anemia
Observation/Rituximab/CHOP as treatment
EBV positive is sometimes seen (not burkitt's!)
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
huge expansion of marginal zone
15-30% become prolymphocytic leukemia
diffuse effacement/psuedofollicles
not technically a lymphoma, but does involve mature B cells
Zap 70+ or Zap 70 -
uncommon, less than 5 percent
BCL6+, CD10+, BCL2-
really attacks facial bones
85% Bone Marrow involvement
1/3 of all NHL's
most common lymphoid malignancy in African Americans
presents at single site, bring patients in early
most common lymphoid malignancy in childhood
Most common NHL
lymphoepithelial lesions
Does dale frank hate medical students? (T/F)
Ki67 rate is low
three main types: endemic, sporadic, everyone has aids
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
paratrabecular aggregates
osteoclast activation leads to hypercalcemia
serum hyperviscosity
interstitial aggregates
starry sky
Bence Jones protein
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
smudge cells
paraprotein production (sometimes)
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
grading based on centroblast number/nodular vs. diffuse growth
abdominal (ileocecal) masses more common
proliferation rate is high, Ki67+ 40-90%
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
male to female ratio is 2:1
treatment must begin IMMEDIATELY
express CD56 (NCAM)
spectrum from monoclonal gammopathy of undetermined significance
lipid vacuoles in cells

You're not logged in!

Compare scores with friends on all Sporcle quizzes.
Sign Up with Email
Log In

You Might Also Like...

Show Comments