MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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15-30% become prolymphocytic leukemia
extranodal involvement uncommon
1/3 of all NHL's
10% undergo Richter's transformation
t(11:18) common/ also t(1:14) and t(14:18)
serum hyperviscosity
flame cell
severe immunodeficiency due to paraprotein
mott cells
Observation/Rituximab/CHOP as treatment
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
spectrum from monoclonal gammopathy of undetermined significance
not technically a lymphoma, but does involve mature B cells
diffuse effacement/psuedofollicles
Does dale frank hate medical students? (T/F)
deletion 13q/11q/trisomy 12/17p
fish-flesh appearance
spread quickly to other mucosal sites but may be treated with antibiotics early
30-50% transform to DLBCL
paratrabecular aggregates
really attacks facial bones
Ki67 rate is low
Most common NHL
osteoclast activation leads to hypercalcemia
treatment must begin IMMEDIATELY
most common leukemia in adults
interstitial aggregates
50% IgG, 25% IgA
huge expansion of marginal zone
three separate diseases: nodal, extranodal, splenic
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
lipid vacuoles in cells
paraprotein production (sometimes)
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
aggressive extranodal with CNS involvement
abdominal (ileocecal) masses more common
extreme paraprotein production
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
most common lymphoid malignancy in African Americans
three main types: endemic, sporadic, everyone has aids
grading based on centroblast number/nodular vs. diffuse growth
most common lymphoid malignancy in childhood
marrow replacement leads to severe anemia
proliferation rate is high, Ki67+ 40-90%
BCL6+, CD10+, BCL2-
multifocal, destroys bone
male to female ratio is 2:1
express CD56 (NCAM)
hypovolemia due to hypercalcemia
Ki67 100%
two main types: germinal center or activated b cell
lymphoepithelial lesions
uncommon, less than 5 percent
85% Bone Marrow involvement
starry sky
presents at single site, bring patients in early
can evolve or start de novo
MUM1 (IRF4), BCL6, BCL10 positive
Zap 70+ or Zap 70 -
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
renal failure (casting) due to paraprotein
peripheral blood involvement very common
morphology (centroblastic/immunoblastic) not important
10-15% get AIHA caused by benign cells
Bence Jones protein
smudge cells
plasma cells account for 10% of cellularity
t(8;14) cMYC translocation
EBV positive is sometimes seen (not burkitt's!)
pleiomorphic and heterogenous, difficult to predict behavior

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Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank