MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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not technically a lymphoma, but does involve mature B cells
10-15% get AIHA caused by benign cells
Ki67 rate is low
mott cells
severe immunodeficiency due to paraprotein
uncommon, less than 5 percent
smudge cells
serum hyperviscosity
extreme paraprotein production
fish-flesh appearance
spectrum from monoclonal gammopathy of undetermined significance
15-30% become prolymphocytic leukemia
MUM1 (IRF4), BCL6, BCL10 positive
male to female ratio is 2:1
plasma cells account for 10% of cellularity
flame cell
osteoclast activation leads to hypercalcemia
morphology (centroblastic/immunoblastic) not important
EBV positive is sometimes seen (not burkitt's!)
Does dale frank hate medical students? (T/F)
interstitial aggregates
extranodal involvement uncommon
10% undergo Richter's transformation
30-50% transform to DLBCL
spread quickly to other mucosal sites but may be treated with antibiotics early
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
85% Bone Marrow involvement
t(8;14) cMYC translocation
treatment must begin IMMEDIATELY
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
BCL6+, CD10+, BCL2-
Bence Jones protein
Most common NHL
multifocal, destroys bone
Zap 70+ or Zap 70 -
paratrabecular aggregates
abdominal (ileocecal) masses more common
aggressive extranodal with CNS involvement
t(11:18) common/ also t(1:14) and t(14:18)
diffuse effacement/psuedofollicles
Ki67 100%
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
lipid vacuoles in cells
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
renal failure (casting) due to paraprotein
peripheral blood involvement very common
most common lymphoid malignancy in childhood
starry sky
presents at single site, bring patients in early
huge expansion of marginal zone
most common leukemia in adults
two main types: germinal center or activated b cell
1/3 of all NHL's
50% IgG, 25% IgA
grading based on centroblast number/nodular vs. diffuse growth
marrow replacement leads to severe anemia
can evolve or start de novo
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
three separate diseases: nodal, extranodal, splenic
really attacks facial bones
hypovolemia due to hypercalcemia
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
proliferation rate is high, Ki67+ 40-90%
most common lymphoid malignancy in African Americans
lymphoepithelial lesions
express CD56 (NCAM)
pleiomorphic and heterogenous, difficult to predict behavior
Observation/Rituximab/CHOP as treatment
three main types: endemic, sporadic, everyone has aids
paraprotein production (sometimes)
deletion 13q/11q/trisomy 12/17p

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Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank