MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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Prompt
uncommon, less than 5 percent
Zap 70+ or Zap 70 -
extranodal involvement uncommon
plasma cells account for 10% of cellularity
EBV positive is sometimes seen (not burkitt's!)
10-15% get AIHA caused by benign cells
30-50% transform to DLBCL
abdominal (ileocecal) masses more common
grading based on centroblast number/nodular vs. diffuse growth
most common lymphoid malignancy in childhood
rouleaux
male to female ratio is 2:1
85% Bone Marrow involvement
most common leukemia in adults
lymphoepithelial lesions
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
1/3 of all NHL's
peripheral blood involvement very common
proliferation rate is high, Ki67+ 40-90%
most common lymphoid malignancy in African Americans
t(11:18) common/ also t(1:14) and t(14:18)
10% undergo Richter's transformation
Most common NHL
hypovolemia due to hypercalcemia
50% IgG, 25% IgA
flame cell
Prompt
t(14:18)
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
three separate diseases: nodal, extranodal, splenic
deletion 13q/11q/trisomy 12/17p
aggressive extranodal with CNS involvement
BCL2+
paratrabecular aggregates
really attacks facial bones
mott cells
diffuse effacement/psuedofollicles
extreme paraprotein production
spectrum from monoclonal gammopathy of undetermined significance
BCL6+, CD10+, BCL2-
paraprotein production (sometimes)
t(8;14) cMYC translocation
smudge cells
marrow replacement leads to severe anemia
Bence Jones protein
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
severe immunodeficiency due to paraprotein
MUM1 (IRF4), BCL6, BCL10 positive
prolymphocytes/paraimmunoblasts
15-30% become prolymphocytic leukemia
spread quickly to other mucosal sites but may be treated with antibiotics early
serum hyperviscosity
presents at single site, bring patients in early
Prompt
pleiomorphic and heterogenous, difficult to predict behavior
three main types: endemic, sporadic, everyone has aids
not technically a lymphoma, but does involve mature B cells
can evolve or start de novo
13q/14q32
interstitial aggregates
lipid vacuoles in cells
two main types: germinal center or activated b cell
huge expansion of marginal zone
CD5+/BCL2+
Does dale frank hate medical students? (T/F)
renal failure (casting) due to paraprotein
fish-flesh appearance
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
starry sky
Ki67 100%
multifocal, destroys bone
express CD56 (NCAM)
morphology (centroblastic/immunoblastic) not important
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
treatment must begin IMMEDIATELY
osteoclast activation leads to hypercalcemia
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
Ki67 rate is low
Observation/Rituximab/CHOP as treatment

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Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank