MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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Prompt
pleiomorphic and heterogenous, difficult to predict behavior
Does dale frank hate medical students? (T/F)
hypovolemia due to hypercalcemia
Zap 70+ or Zap 70 -
15-30% become prolymphocytic leukemia
express CD56 (NCAM)
spectrum from monoclonal gammopathy of undetermined significance
two main types: germinal center or activated b cell
grading based on centroblast number/nodular vs. diffuse growth
lipid vacuoles in cells
EBV positive is sometimes seen (not burkitt's!)
serum hyperviscosity
BCL2+
Most common NHL
multifocal, destroys bone
marrow replacement leads to severe anemia
starry sky
Observation/Rituximab/CHOP as treatment
spread quickly to other mucosal sites but may be treated with antibiotics early
not technically a lymphoma, but does involve mature B cells
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
three main types: endemic, sporadic, everyone has aids
rouleaux
85% Bone Marrow involvement
paraprotein production (sometimes)
abdominal (ileocecal) masses more common
Prompt
renal failure (casting) due to paraprotein
plasma cells account for 10% of cellularity
t(14:18)
most common leukemia in adults
1/3 of all NHL's
Ki67 100%
CD5+/BCL2+
presents at single site, bring patients in early
50% IgG, 25% IgA
male to female ratio is 2:1
diffuse effacement/psuedofollicles
paratrabecular aggregates
treatment must begin IMMEDIATELY
t(8;14) cMYC translocation
prolymphocytes/paraimmunoblasts
really attacks facial bones
deletion 13q/11q/trisomy 12/17p
30-50% transform to DLBCL
three separate diseases: nodal, extranodal, splenic
Ki67 rate is low
most common lymphoid malignancy in African Americans
extreme paraprotein production
mott cells
t(11:18) common/ also t(1:14) and t(14:18)
lymphoepithelial lesions
MUM1 (IRF4), BCL6, BCL10 positive
Prompt
huge expansion of marginal zone
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
peripheral blood involvement very common
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
most common lymphoid malignancy in childhood
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
proliferation rate is high, Ki67+ 40-90%
can evolve or start de novo
Bence Jones protein
10% undergo Richter's transformation
flame cell
aggressive extranodal with CNS involvement
10-15% get AIHA caused by benign cells
smudge cells
osteoclast activation leads to hypercalcemia
morphology (centroblastic/immunoblastic) not important
13q/14q32
fish-flesh appearance
extranodal involvement uncommon
BCL6+, CD10+, BCL2-
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
interstitial aggregates
severe immunodeficiency due to paraprotein
uncommon, less than 5 percent

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Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank