MDTI - Dale Frank Lectures

Random Science or NHL Quiz

Can you name the MDTI NHL buzzwords?

Quiz not verified by Sporcle

How to Play
treatment must begin IMMEDIATELY
presents at single site, bring patients in early
diffuse effacement/psuedofollicles
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
proliferation rate is high, Ki67+ 40-90%
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
can evolve or start de novo
three main types: endemic, sporadic, everyone has aids
male to female ratio is 2:1
EBV positive is sometimes seen (not burkitt's!)
BCL6+, CD10+, BCL2-
starry sky
fish-flesh appearance
severe immunodeficiency due to paraprotein
lymphoepithelial lesions
peripheral blood involvement very common
1/3 of all NHL's
interstitial aggregates
Ki67 rate is low
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
extranodal involvement uncommon
10% undergo Richter's transformation
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
hypovolemia due to hypercalcemia
renal failure (casting) due to paraprotein
serum hyperviscosity
85% Bone Marrow involvement
not technically a lymphoma, but does involve mature B cells
paraprotein production (sometimes)
two main types: germinal center or activated b cell
express CD56 (NCAM)
lipid vacuoles in cells
15-30% become prolymphocytic leukemia
most common leukemia in adults
Ki67 100%
Does dale frank hate medical students? (T/F)
mott cells
osteoclast activation leads to hypercalcemia
Observation/Rituximab/CHOP as treatment
uncommon, less than 5 percent
really attacks facial bones
huge expansion of marginal zone
extreme paraprotein production
three separate diseases: nodal, extranodal, splenic
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
10-15% get AIHA caused by benign cells
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
abdominal (ileocecal) masses more common
spectrum from monoclonal gammopathy of undetermined significance
Most common NHL
t(11:18) common/ also t(1:14) and t(14:18)
marrow replacement leads to severe anemia
paratrabecular aggregates
smudge cells
most common lymphoid malignancy in African Americans
MUM1 (IRF4), BCL6, BCL10 positive
Zap 70+ or Zap 70 -
most common lymphoid malignancy in childhood
deletion 13q/11q/trisomy 12/17p
spread quickly to other mucosal sites but may be treated with antibiotics early
30-50% transform to DLBCL
t(8;14) cMYC translocation
plasma cells account for 10% of cellularity
pleiomorphic and heterogenous, difficult to predict behavior
morphology (centroblastic/immunoblastic) not important
multifocal, destroys bone
50% IgG, 25% IgA
Bence Jones protein
grading based on centroblast number/nodular vs. diffuse growth
aggressive extranodal with CNS involvement
flame cell

Friend Scores

  Player Best Score Plays Last Played
You You haven't played this game yet.

You Might Also Like...


Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank