MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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lymphoepithelial lesions
fish-flesh appearance
really attacks facial bones
Observation/Rituximab/CHOP as treatment
Does dale frank hate medical students? (T/F)
10-15% get AIHA caused by benign cells
extreme paraprotein production
paratrabecular aggregates
deletion 13q/11q/trisomy 12/17p
Ki67 100%
can evolve or start de novo
treatment must begin IMMEDIATELY
interstitial aggregates
morphology (centroblastic/immunoblastic) not important
Ki67 rate is low
osteoclast activation leads to hypercalcemia
most common lymphoid malignancy in childhood
smudge cells
marrow replacement leads to severe anemia
Most common NHL
multifocal, destroys bone
express CD56 (NCAM)
not technically a lymphoma, but does involve mature B cells
three separate diseases: nodal, extranodal, splenic
spectrum from monoclonal gammopathy of undetermined significance
three main types: endemic, sporadic, everyone has aids
extranodal involvement uncommon
uncommon, less than 5 percent
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
50% IgG, 25% IgA
abdominal (ileocecal) masses more common
1/3 of all NHL's
huge expansion of marginal zone
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
starry sky
BCL6+, CD10+, BCL2-
presents at single site, bring patients in early
85% Bone Marrow involvement
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
aggressive extranodal with CNS involvement
serum hyperviscosity
two main types: germinal center or activated b cell
EBV positive is sometimes seen (not burkitt's!)
flame cell
hypovolemia due to hypercalcemia
male to female ratio is 2:1
MUM1 (IRF4), BCL6, BCL10 positive
renal failure (casting) due to paraprotein
peripheral blood involvement very common
lipid vacuoles in cells
most common leukemia in adults
paraprotein production (sometimes)
Bence Jones protein
spread quickly to other mucosal sites but may be treated with antibiotics early
t(8;14) cMYC translocation
plasma cells account for 10% of cellularity
most common lymphoid malignancy in African Americans
t(11:18) common/ also t(1:14) and t(14:18)
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
severe immunodeficiency due to paraprotein
mott cells
proliferation rate is high, Ki67+ 40-90%
grading based on centroblast number/nodular vs. diffuse growth
Zap 70+ or Zap 70 -
10% undergo Richter's transformation
30-50% transform to DLBCL
pleiomorphic and heterogenous, difficult to predict behavior
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
15-30% become prolymphocytic leukemia
diffuse effacement/psuedofollicles
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)

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