MDTI - Dale Frank Lectures

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Can you name the MDTI NHL buzzwords?

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t(8;14) cMYC translocation
30-50% transform to DLBCL
Ki67 100%
pleiomorphic and heterogenous, difficult to predict behavior
spectrum from monoclonal gammopathy of undetermined significance
60% nodal, 40% extranodal in GI (unlike indolent lymphomas)
Observation/Rituximab/CHOP as treatment
15-30% become prolymphocytic leukemia
starry sky
Toughie: tumor inhibiting miR-15a/MiR-16-1 lost with 13q deletion
hypovolemia due to hypercalcemia
abdominal (ileocecal) masses more common
10-15% get AIHA caused by benign cells
most common leukemia in adults
Ki67 rate is low
paraprotein production (sometimes)
multifocal, destroys bone
uncommon, less than 5 percent
three separate diseases: nodal, extranodal, splenic
huge expansion of marginal zone
grading based on centroblast number/nodular vs. diffuse growth
aggressive extranodal with CNS involvement
fish-flesh appearance
lipid vacuoles in cells
really attacks facial bones
treatment must begin IMMEDIATELY
MUM1 (IRF4), BCL6, BCL10 positive
Bence Jones protein
paratrabecular aggregates
Most common NHL
Does dale frank hate medical students? (T/F)
two main types: germinal center or activated b cell
severe immunodeficiency due to paraprotein
osteoclast activation leads to hypercalcemia
not technically a lymphoma, but does involve mature B cells
proliferation rate is high, Ki67+ 40-90%
50% IgG, 25% IgA
most common lymphoid malignancy in African Americans
interstitial aggregates
arises from chronic inflammation (h.pylori, campy, burrelia, HepC?)
smudge cells
presents at single site, bring patients in early
BCL6+, CD10+, BCL2-
3 cardinal features: small mature lymphos, monocytoid B cells, plasma cells
diagnosis (immunophenotype) of exclusion; BCL2+, CD10-, BCL6-
three main types: endemic, sporadic, everyone has aids
peripheral blood involvement very common
extreme paraprotein production
can evolve or start de novo
express CD56 (NCAM)
serum hyperviscosity
t(11:18) common/ also t(1:14) and t(14:18)
most common lymphoid malignancy in childhood
plasma cells account for 10% of cellularity
1/3 of all NHL's
renal failure (casting) due to paraprotein
mott cells
lymphoepithelial lesions
male to female ratio is 2:1
flame cell
deletion 13q/11q/trisomy 12/17p
marrow replacement leads to severe anemia
85% Bone Marrow involvement
extranodal involvement uncommon
spread quickly to other mucosal sites but may be treated with antibiotics early
Zap 70+ or Zap 70 -
EBV positive is sometimes seen (not burkitt's!)
diffuse effacement/psuedofollicles
age>60, LDH levels up, multiple extranodal involvement are all bad prognostic signs
10% undergo Richter's transformation
morphology (centroblastic/immunoblastic) not important

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Created Feb 5, 2012ReportNominate
Tags:NHL, buzzard, dale, frank