| Clue | Character |
| Theoretical physicist, aka Moon Pie to his Meemaw | |
| Experimental physicist, receives a Snuggie from Penny | |
| Particle astrophysicist, was in People Magazine for discovering a planet | |
| Engineer, threatens to kill Sheldon with a crossbow at the North Pole | |
| Waitress at The Cheesecake Factory, in one episode starts a hair barrette business | |
| Experimental physicist that works in Leonard's lab, supports loop quantum gravity | |
| Penny's boyfriend that meets the guys after they come home from the Renaissance Fair | |
| Plasma physicist, enjoys rock-climbing and ventriloquism | |
| Sheldon, Leonard, Raj, and Howard's boss | |
| | Clue | Character |
| Surgeon, only one of Leonard's girlfriends that Sheldon finds 'tolerable' | |
| Graduate student, obsessed with Sheldon | |
| Experimental physicist, had a relationship with Penny until she found out he was married | |
| Penny's ex-boyfriend, owes her $1800 | |
| Psychiatrist and neuroscientist, Leonard's mother | |
| Winner of Nobel Peace Prize, guest-speaker at a symposium in San Francisco | |
| Actress from The Terminator, rode the same train as the guys | |
| Attractive blonde, moves in above Sheldon and Leonard | |
| Runs the comic book store | |
|