USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Male child, recurrent infections, no mature B cells
Vascular birthmark (port-wine stain)
Hypercoagulability leading to migrating DVTs and vascultitis
Fibrous plaques in soft tissue of penis
Rash on palms and soles
Indurated, non-painful ulcerated genital lesion
Splinter hemorrhages in fingernails
Child uses arms to stand up from squat
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Child with fever develops red rash on face that spread to body
“Strawberry tongue” (Vasculitis)
Hypoxemia, polycythemia, hypercapnia
Bounding pulses, diastolic heart murmur, head bobbing
Single palm crease
Palpable purpura, joint pain, abdominal pain (child)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Systolic ejection murmur (crescendo-decrescendo)
“Cherry-red spot” on macula (hexosaminidase
Red “currant jelly” sputum in alcoholic or diabetic patients
Polyuria, acidosis, growth failure, electrolyte imbalances
Hypertension, hypokalemia, metabolic acidosis
Hereditary nephritis, sensorineural hearing loss, cataracts
Sudden swollen / painful big toe joint, tophi
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Back pain, fever, night sweats, weight loss
Cutaneous / dermal edema due to connective tissue deposition
Bluish line on gingiva
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Cold intolerance
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Pancreatic, pituitary, parathyroid tumors
Painful, pale, cold fingers / toes
Gout, mental retardation, self-mutilating behavior in boy
“Worst headache of my life”
Muscoal bleeding and prolonged bleeding time
Dermatitis, dementia, diarrhea
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Lucid interval after traumatic brain injury
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Severe RLQ pain with rebound tenderness
Situs inversus, chronic sinusitis, bronchiectasis
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Pink complexion, dyspnea, hyperventilation
“Waxy” casts with very low urine flow
Jaundice, RUQ pain, fever
Deep labored breathing / hyperventilation
Conjugate lateral gaze palsy, horizontal diplopia
“Cherry-red spot” on macula (vascular)
Resting tremor, rigidity, akinesia, postural instability
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Thyroid and parathyroid tumors, pheochromocytoma
Rash on palms and soles
No lactation postpartum, absent menstruation, cold intolerance
“Cherry-red spot” on macula (sphingomyelinase)
Green-yellow rings around peripheral cornea
Weight loss, diarrhea, arthritis, fever, adenopathy
Vomiting blood following esophagogastric lacerations
Bone pain, bone enlargement, arthritis
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Calf pseudohypertrophy
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Unilateral facial dropping invoving forhead
Painless jaundice
Oscillating slow/fast breathing
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Adrenal hemorrhage, hypotension, DIC
Retinal hemorrhages with pale centers
Pupil accommodates but doesn’t react
Smooth, flat, moist white lesions on genitals
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
“Strawberry tongue” (Strep. pyogenes)
Recurrent colds unusual eczema, high serum IgE
Infant with hypoglycemia, failure to thrive, and hepatomegaly
“Strawberry tongue” (Staph. aureus)
Continuous “machinery” heart murmur
Indurated, painful ulcerated genital lesion with exudates
Severe jaundice in neonate
Fever, cough, conjunctivitis, coryza, diffuse rash
Red, itchy, swollen rash of nipple areola
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Ptosis, miosis, anhydrosis
Dilated cardiomyopathy, edema, polyneuropathy
Neonate with arm paralysis following difficult birth
Achilles tendon xanthoma
Swollen, hard, painful finger joints
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Keratin pearls in a skin biopsy
Red urine in the morning, fragile RBCs
Dark purple skin / mouth nodules
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
WBC casts in urine
Skin hyperpigmentation
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Positive anterior “drawer sign”
Urethritis, conjunctivitis, arthritis in a male
Facial muscle spasm upon tapping
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Painful blue fingers toes, hemolytic anemia
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Slow, progressive muscle weakness in boys
Streak ovaries, congenital heart disease, horseshoe kidney
Toe extension / fanning upon plantar scrape
Painful, raised red lesions on palms and soles
Bilateral hilar adenopathy, uveitis
Athlete with polycythemia
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Abdominal pain, ascites, hepatomegaly
Blue sclera
Large rash with bull’s-eye appearance
Enlarged, hard left supraclavicular node
Chorea, dementia, caudate degeneration
Swollen gums, mucous leeding, poor wound healing, spots on skin
Dog or cat bite resulting in infection
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Fever, night sweats, weight loss
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Fat, female, forty, and fertile
Elastic skin, hypermobility of joints
Painful erythematous lesions on palms and soles
Dry eyes, dry mouth, arthritis

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