USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Facial muscle spasm upon tapping
Hypercoagulability leading to migrating DVTs and vascultitis
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
“Cherry-red spot” on macula (sphingomyelinase)
Fever, night sweats, weight loss
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Recurrent colds unusual eczema, high serum IgE
Hypertension, hypokalemia, metabolic acidosis
“Waxy” casts with very low urine flow
Green-yellow rings around peripheral cornea
Dog or cat bite resulting in infection
Child with fever develops red rash on face that spread to body
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Indurated, painful ulcerated genital lesion with exudates
Vascular birthmark (port-wine stain)
Blue sclera
Continuous “machinery” heart murmur
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Lucid interval after traumatic brain injury
Large rash with bull’s-eye appearance
Swollen gums, mucous leeding, poor wound healing, spots on skin
Sudden swollen / painful big toe joint, tophi
Fever, cough, conjunctivitis, coryza, diffuse rash
Hereditary nephritis, sensorineural hearing loss, cataracts
Painful, pale, cold fingers / toes
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Bounding pulses, diastolic heart murmur, head bobbing
Bluish line on gingiva
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Situs inversus, chronic sinusitis, bronchiectasis
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Indurated, non-painful ulcerated genital lesion
Neonate with arm paralysis following difficult birth
Red “currant jelly” sputum in alcoholic or diabetic patients
Abdominal pain, ascites, hepatomegaly
Child uses arms to stand up from squat
Unilateral facial dropping invoving forhead
Chorea, dementia, caudate degeneration
Oscillating slow/fast breathing
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Muscoal bleeding and prolonged bleeding time
Bilateral hilar adenopathy, uveitis
Skin hyperpigmentation
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Red urine in the morning, fragile RBCs
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Achilles tendon xanthoma
Positive anterior “drawer sign”
Severe jaundice in neonate
Dermatitis, dementia, diarrhea
Back pain, fever, night sweats, weight loss
Bone pain, bone enlargement, arthritis
Pink complexion, dyspnea, hyperventilation
“Worst headache of my life”
No lactation postpartum, absent menstruation, cold intolerance
Jaundice, RUQ pain, fever
Fibrous plaques in soft tissue of penis
Painful blue fingers toes, hemolytic anemia
“Strawberry tongue” (Strep. pyogenes)
Cold intolerance
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Slow, progressive muscle weakness in boys
Vomiting blood following esophagogastric lacerations
Resting tremor, rigidity, akinesia, postural instability
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Dry eyes, dry mouth, arthritis
Swollen, hard, painful finger joints
Athlete with polycythemia
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Severe RLQ pain with rebound tenderness
Conjugate lateral gaze palsy, horizontal diplopia
Thyroid and parathyroid tumors, pheochromocytoma
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Retinal hemorrhages with pale centers
“Cherry-red spot” on macula (vascular)
Deep labored breathing / hyperventilation
“Strawberry tongue” (Staph. aureus)
Enlarged, hard left supraclavicular node
“Strawberry tongue” (Vasculitis)
Male child, recurrent infections, no mature B cells
Palpable purpura, joint pain, abdominal pain (child)
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Elastic skin, hypermobility of joints
Red, itchy, swollen rash of nipple areola
Polyuria, acidosis, growth failure, electrolyte imbalances
Streak ovaries, congenital heart disease, horseshoe kidney
Smooth, flat, moist white lesions on genitals
Gout, mental retardation, self-mutilating behavior in boy
Dilated cardiomyopathy, edema, polyneuropathy
Ptosis, miosis, anhydrosis
Painless jaundice
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Dark purple skin / mouth nodules
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Painful erythematous lesions on palms and soles
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Rash on palms and soles
Splinter hemorrhages in fingernails
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Urethritis, conjunctivitis, arthritis in a male
Adrenal hemorrhage, hypotension, DIC
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Calf pseudohypertrophy
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Single palm crease
Systolic ejection murmur (crescendo-decrescendo)
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Pancreatic, pituitary, parathyroid tumors
Keratin pearls in a skin biopsy
Rash on palms and soles
WBC casts in urine
Toe extension / fanning upon plantar scrape
Hypoxemia, polycythemia, hypercapnia
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Weight loss, diarrhea, arthritis, fever, adenopathy
“Cherry-red spot” on macula (hexosaminidase
Pupil accommodates but doesn’t react
Cutaneous / dermal edema due to connective tissue deposition
Painful, raised red lesions on palms and soles
Fat, female, forty, and fertile

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