Science / USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Indurated, painful ulcerated genital lesion with exudates
Bluish line on gingiva
Vomiting blood following esophagogastric lacerations
Deep labored breathing / hyperventilation
Elastic skin, hypermobility of joints
Hypertension, hypokalemia, metabolic acidosis
Abdominal pain, ascites, hepatomegaly
Bone pain, bone enlargement, arthritis
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Dark purple skin / mouth nodules
Painful erythematous lesions on palms and soles
Dilated cardiomyopathy, edema, polyneuropathy
Retinal hemorrhages with pale centers
Gout, mental retardation, self-mutilating behavior in boy
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Positive anterior “drawer sign”
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Resting tremor, rigidity, akinesia, postural instability
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Hypercoagulability leading to migrating DVTs and vascultitis
Hereditary nephritis, sensorineural hearing loss, cataracts
Sudden swollen / painful big toe joint, tophi
Fever, night sweats, weight loss
Cutaneous / dermal edema due to connective tissue deposition
Red, itchy, swollen rash of nipple areola
Cold intolerance
Skin hyperpigmentation
Neonate with arm paralysis following difficult birth
Fibrous plaques in soft tissue of penis
Male child, recurrent infections, no mature B cells
“Cherry-red spot” on macula (hexosaminidase
Fever, cough, conjunctivitis, coryza, diffuse rash
Painless jaundice
Streak ovaries, congenital heart disease, horseshoe kidney
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Adrenal hemorrhage, hypotension, DIC
WBC casts in urine
Palpable purpura, joint pain, abdominal pain (child)
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Green-yellow rings around peripheral cornea
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Fat, female, forty, and fertile
Severe jaundice in neonate
“Strawberry tongue” (Strep. pyogenes)
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Child with fever develops red rash on face that spread to body
Red urine in the morning, fragile RBCs
Red “currant jelly” sputum in alcoholic or diabetic patients
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Chorea, dementia, caudate degeneration
Severe RLQ pain with rebound tenderness
Bilateral hilar adenopathy, uveitis
Hypoxemia, polycythemia, hypercapnia
Swollen gums, mucous leeding, poor wound healing, spots on skin
Systolic ejection murmur (crescendo-decrescendo)
“Strawberry tongue” (Staph. aureus)
“Strawberry tongue” (Vasculitis)
Swollen, hard, painful finger joints
“Worst headache of my life”
Child uses arms to stand up from squat
Dog or cat bite resulting in infection
Back pain, fever, night sweats, weight loss
Dermatitis, dementia, diarrhea
Facial muscle spasm upon tapping
Indurated, non-painful ulcerated genital lesion
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Smooth, flat, moist white lesions on genitals
Pupil accommodates but doesn’t react
Painful, raised red lesions on palms and soles
Oscillating slow/fast breathing
Rash on palms and soles
Lucid interval after traumatic brain injury
Situs inversus, chronic sinusitis, bronchiectasis
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
“Cherry-red spot” on macula (vascular)
Pancreatic, pituitary, parathyroid tumors
Conjugate lateral gaze palsy, horizontal diplopia
Blue sclera
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Slow, progressive muscle weakness in boys
Rash on palms and soles
Vascular birthmark (port-wine stain)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Single palm crease
“Cherry-red spot” on macula (sphingomyelinase)
Painful blue fingers toes, hemolytic anemia
Bounding pulses, diastolic heart murmur, head bobbing
Polyuria, acidosis, growth failure, electrolyte imbalances
Recurrent colds unusual eczema, high serum IgE
Urethritis, conjunctivitis, arthritis in a male
Painful, pale, cold fingers / toes
Jaundice, RUQ pain, fever
Dry eyes, dry mouth, arthritis
No lactation postpartum, absent menstruation, cold intolerance
Ptosis, miosis, anhydrosis
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Athlete with polycythemia
Unilateral facial dropping invoving forhead
Achilles tendon xanthoma
Thyroid and parathyroid tumors, pheochromocytoma
“Waxy” casts with very low urine flow
Muscoal bleeding and prolonged bleeding time
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Calf pseudohypertrophy
Keratin pearls in a skin biopsy
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Enlarged, hard left supraclavicular node
Continuous “machinery” heart murmur
Large rash with bull’s-eye appearance
Toe extension / fanning upon plantar scrape
Pink complexion, dyspnea, hyperventilation
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Weight loss, diarrhea, arthritis, fever, adenopathy
Splinter hemorrhages in fingernails
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas

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