USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Male child, recurrent infections, no mature B cells
Fibrous plaques in soft tissue of penis
Green-yellow rings around peripheral cornea
Situs inversus, chronic sinusitis, bronchiectasis
Hereditary nephritis, sensorineural hearing loss, cataracts
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Polyuria, acidosis, growth failure, electrolyte imbalances
“Strawberry tongue” (Strep. pyogenes)
Cutaneous / dermal edema due to connective tissue deposition
Bluish line on gingiva
Fat, female, forty, and fertile
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Cold intolerance
Hypercoagulability leading to migrating DVTs and vascultitis
Enlarged, hard left supraclavicular node
Urethritis, conjunctivitis, arthritis in a male
Swollen, hard, painful finger joints
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
“Cherry-red spot” on macula (sphingomyelinase)
Smooth, flat, moist white lesions on genitals
Neonate with arm paralysis following difficult birth
Conjugate lateral gaze palsy, horizontal diplopia
Vomiting blood following esophagogastric lacerations
Athlete with polycythemia
Streak ovaries, congenital heart disease, horseshoe kidney
Calf pseudohypertrophy
Muscoal bleeding and prolonged bleeding time
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Toe extension / fanning upon plantar scrape
Red “currant jelly” sputum in alcoholic or diabetic patients
Facial muscle spasm upon tapping
“Cherry-red spot” on macula (vascular)
Retinal hemorrhages with pale centers
Bone pain, bone enlargement, arthritis
Oscillating slow/fast breathing
Elastic skin, hypermobility of joints
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Indurated, non-painful ulcerated genital lesion
Jaundice, RUQ pain, fever
Chorea, dementia, caudate degeneration
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Painful blue fingers toes, hemolytic anemia
“Strawberry tongue” (Staph. aureus)
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Ptosis, miosis, anhydrosis
Child uses arms to stand up from squat
Pupil accommodates but doesn’t react
Achilles tendon xanthoma
Child with fever develops red rash on face that spread to body
Painless jaundice
Skin hyperpigmentation
Deep labored breathing / hyperventilation
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Rash on palms and soles
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Blue sclera
Painful, raised red lesions on palms and soles
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Severe RLQ pain with rebound tenderness
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Pancreatic, pituitary, parathyroid tumors
Continuous “machinery” heart murmur
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Lucid interval after traumatic brain injury
Recurrent colds unusual eczema, high serum IgE
Dilated cardiomyopathy, edema, polyneuropathy
“Waxy” casts with very low urine flow
Resting tremor, rigidity, akinesia, postural instability
Gout, mental retardation, self-mutilating behavior in boy
Fever, cough, conjunctivitis, coryza, diffuse rash
Red urine in the morning, fragile RBCs
Rash on palms and soles
Systolic ejection murmur (crescendo-decrescendo)
WBC casts in urine
Red, itchy, swollen rash of nipple areola
Dry eyes, dry mouth, arthritis
Slow, progressive muscle weakness in boys
Splinter hemorrhages in fingernails
Painful erythematous lesions on palms and soles
Painful, pale, cold fingers / toes
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Back pain, fever, night sweats, weight loss
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Hypertension, hypokalemia, metabolic acidosis
Hypoxemia, polycythemia, hypercapnia
Bounding pulses, diastolic heart murmur, head bobbing
Pink complexion, dyspnea, hyperventilation
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
“Strawberry tongue” (Vasculitis)
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Unilateral facial dropping invoving forhead
Keratin pearls in a skin biopsy
Swollen gums, mucous leeding, poor wound healing, spots on skin
Large rash with bull’s-eye appearance
Positive anterior “drawer sign”
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Bilateral hilar adenopathy, uveitis
Vascular birthmark (port-wine stain)
Abdominal pain, ascites, hepatomegaly
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Single palm crease
Adrenal hemorrhage, hypotension, DIC
Dermatitis, dementia, diarrhea
Dark purple skin / mouth nodules
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Severe jaundice in neonate
Fever, night sweats, weight loss
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Thyroid and parathyroid tumors, pheochromocytoma
Sudden swollen / painful big toe joint, tophi
“Cherry-red spot” on macula (hexosaminidase
Dog or cat bite resulting in infection
“Worst headache of my life”
Palpable purpura, joint pain, abdominal pain (child)
Weight loss, diarrhea, arthritis, fever, adenopathy
Indurated, painful ulcerated genital lesion with exudates
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
No lactation postpartum, absent menstruation, cold intolerance
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Vasculitis from exposure to endotoxin causing glomerular thrombosis

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