USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Child uses arms to stand up from squat
Dermatitis, dementia, diarrhea
Rash on palms and soles
“Cherry-red spot” on macula (sphingomyelinase)
Ptosis, miosis, anhydrosis
Chorea, dementia, caudate degeneration
Oscillating slow/fast breathing
Achilles tendon xanthoma
Toe extension / fanning upon plantar scrape
Sudden swollen / painful big toe joint, tophi
Dog or cat bite resulting in infection
Keratin pearls in a skin biopsy
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Splinter hemorrhages in fingernails
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Severe jaundice in neonate
Bluish line on gingiva
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
No lactation postpartum, absent menstruation, cold intolerance
Continuous “machinery” heart murmur
Conjugate lateral gaze palsy, horizontal diplopia
Cold intolerance
Hyperphagia, hypersexuality, hyperorality, hyperdocility
“Worst headache of my life”
Streak ovaries, congenital heart disease, horseshoe kidney
Pancreatic, pituitary, parathyroid tumors
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Calf pseudohypertrophy
Painful, pale, cold fingers / toes
Painful blue fingers toes, hemolytic anemia
“Waxy” casts with very low urine flow
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Systolic ejection murmur (crescendo-decrescendo)
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Situs inversus, chronic sinusitis, bronchiectasis
Skin hyperpigmentation
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Abdominal pain, ascites, hepatomegaly
Bounding pulses, diastolic heart murmur, head bobbing
Deep labored breathing / hyperventilation
Hereditary nephritis, sensorineural hearing loss, cataracts
Smooth, flat, moist white lesions on genitals
Enlarged, hard left supraclavicular node
Hypoxemia, polycythemia, hypercapnia
Urethritis, conjunctivitis, arthritis in a male
Single palm crease
Resting tremor, rigidity, akinesia, postural instability
Swollen, hard, painful finger joints
Weight loss, diarrhea, arthritis, fever, adenopathy
Bilateral hilar adenopathy, uveitis
Large rash with bull’s-eye appearance
Vascular birthmark (port-wine stain)
Cutaneous / dermal edema due to connective tissue deposition
Dry eyes, dry mouth, arthritis
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Hypertension, hypokalemia, metabolic acidosis
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Adrenal hemorrhage, hypotension, DIC
Facial muscle spasm upon tapping
Fever, night sweats, weight loss
Indurated, painful ulcerated genital lesion with exudates
Muscoal bleeding and prolonged bleeding time
Red “currant jelly” sputum in alcoholic or diabetic patients
“Cherry-red spot” on macula (hexosaminidase
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Red, itchy, swollen rash of nipple areola
Unilateral facial dropping invoving forhead
“Cherry-red spot” on macula (vascular)
Dark purple skin / mouth nodules
Neonate with arm paralysis following difficult birth
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
“Strawberry tongue” (Staph. aureus)
Hypercoagulability leading to migrating DVTs and vascultitis
Elastic skin, hypermobility of joints
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Severe RLQ pain with rebound tenderness
Positive anterior “drawer sign”
Swollen gums, mucous leeding, poor wound healing, spots on skin
Dilated cardiomyopathy, edema, polyneuropathy
Red urine in the morning, fragile RBCs
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Polyuria, acidosis, growth failure, electrolyte imbalances
Indurated, non-painful ulcerated genital lesion
Thyroid and parathyroid tumors, pheochromocytoma
Bone pain, bone enlargement, arthritis
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
“Strawberry tongue” (Strep. pyogenes)
Slow, progressive muscle weakness in boys
Gout, mental retardation, self-mutilating behavior in boy
Jaundice, RUQ pain, fever
“Strawberry tongue” (Vasculitis)
Fibrous plaques in soft tissue of penis
Male child, recurrent infections, no mature B cells
Blue sclera
Fever, cough, conjunctivitis, coryza, diffuse rash
Palpable purpura, joint pain, abdominal pain (child)
Child with fever develops red rash on face that spread to body
Lucid interval after traumatic brain injury
Pupil accommodates but doesn’t react
WBC casts in urine
Vomiting blood following esophagogastric lacerations
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Rash on palms and soles
Pink complexion, dyspnea, hyperventilation
Painful erythematous lesions on palms and soles
Recurrent colds unusual eczema, high serum IgE
Green-yellow rings around peripheral cornea
Athlete with polycythemia
Back pain, fever, night sweats, weight loss
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Fat, female, forty, and fertile
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Retinal hemorrhages with pale centers
Painless jaundice
Painful, raised red lesions on palms and soles

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