USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Gout, mental retardation, self-mutilating behavior in boy
Painful blue fingers toes, hemolytic anemia
Green-yellow rings around peripheral cornea
Polyuria, acidosis, growth failure, electrolyte imbalances
Jaundice, RUQ pain, fever
Bilateral hilar adenopathy, uveitis
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Keratin pearls in a skin biopsy
Pupil accommodates but doesn’t react
Severe RLQ pain with rebound tenderness
Conjugate lateral gaze palsy, horizontal diplopia
Continuous “machinery” heart murmur
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Hypercoagulability leading to migrating DVTs and vascultitis
Dry eyes, dry mouth, arthritis
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Resting tremor, rigidity, akinesia, postural instability
Child with fever develops red rash on face that spread to body
Adrenal hemorrhage, hypotension, DIC
Toe extension / fanning upon plantar scrape
Swollen, hard, painful finger joints
Chorea, dementia, caudate degeneration
Situs inversus, chronic sinusitis, bronchiectasis
Athlete with polycythemia
Dilated cardiomyopathy, edema, polyneuropathy
Slow, progressive muscle weakness in boys
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
WBC casts in urine
Unilateral facial dropping invoving forhead
Fever, cough, conjunctivitis, coryza, diffuse rash
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Pancreatic, pituitary, parathyroid tumors
Neonate with arm paralysis following difficult birth
Palpable purpura, joint pain, abdominal pain (child)
Indurated, painful ulcerated genital lesion with exudates
Fever, night sweats, weight loss
“Cherry-red spot” on macula (hexosaminidase
Ptosis, miosis, anhydrosis
Skin hyperpigmentation
Urethritis, conjunctivitis, arthritis in a male
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Weight loss, diarrhea, arthritis, fever, adenopathy
“Strawberry tongue” (Staph. aureus)
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Deep labored breathing / hyperventilation
Dog or cat bite resulting in infection
Achilles tendon xanthoma
Abdominal pain, ascites, hepatomegaly
Cutaneous / dermal edema due to connective tissue deposition
Painless jaundice
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Painful, raised red lesions on palms and soles
Dark purple skin / mouth nodules
Calf pseudohypertrophy
Sudden swollen / painful big toe joint, tophi
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Large rash with bull’s-eye appearance
Lucid interval after traumatic brain injury
Smooth, flat, moist white lesions on genitals
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Single palm crease
Painful erythematous lesions on palms and soles
“Strawberry tongue” (Vasculitis)
Back pain, fever, night sweats, weight loss
Fibrous plaques in soft tissue of penis
Rash on palms and soles
Vascular birthmark (port-wine stain)
“Waxy” casts with very low urine flow
Thyroid and parathyroid tumors, pheochromocytoma
Elastic skin, hypermobility of joints
Fat, female, forty, and fertile
“Cherry-red spot” on macula (vascular)
Red urine in the morning, fragile RBCs
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Hereditary nephritis, sensorineural hearing loss, cataracts
Red, itchy, swollen rash of nipple areola
No lactation postpartum, absent menstruation, cold intolerance
Cold intolerance
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Splinter hemorrhages in fingernails
Blue sclera
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Bluish line on gingiva
Systolic ejection murmur (crescendo-decrescendo)
Vomiting blood following esophagogastric lacerations
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Dermatitis, dementia, diarrhea
Muscoal bleeding and prolonged bleeding time
Recurrent colds unusual eczema, high serum IgE
Rash on palms and soles
Swollen gums, mucous leeding, poor wound healing, spots on skin
Male child, recurrent infections, no mature B cells
Oscillating slow/fast breathing
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Red “currant jelly” sputum in alcoholic or diabetic patients
Retinal hemorrhages with pale centers
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Bone pain, bone enlargement, arthritis
Facial muscle spasm upon tapping
Painful, pale, cold fingers / toes
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
“Strawberry tongue” (Strep. pyogenes)
Streak ovaries, congenital heart disease, horseshoe kidney
“Worst headache of my life”
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Child uses arms to stand up from squat
Severe jaundice in neonate
Positive anterior “drawer sign”
Hypertension, hypokalemia, metabolic acidosis
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Pink complexion, dyspnea, hyperventilation
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
“Cherry-red spot” on macula (sphingomyelinase)
Bounding pulses, diastolic heart murmur, head bobbing
Indurated, non-painful ulcerated genital lesion
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Hypoxemia, polycythemia, hypercapnia
Enlarged, hard left supraclavicular node

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