USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Bilateral hilar adenopathy, uveitis
Child uses arms to stand up from squat
Cold intolerance
Male child, recurrent infections, no mature B cells
Large rash with bull’s-eye appearance
Jaundice, RUQ pain, fever
No lactation postpartum, absent menstruation, cold intolerance
Red “currant jelly” sputum in alcoholic or diabetic patients
Fibrous plaques in soft tissue of penis
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Keratin pearls in a skin biopsy
Severe jaundice in neonate
Neonate with arm paralysis following difficult birth
Bounding pulses, diastolic heart murmur, head bobbing
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Conjugate lateral gaze palsy, horizontal diplopia
Retinal hemorrhages with pale centers
Thyroid and parathyroid tumors, pheochromocytoma
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Ptosis, miosis, anhydrosis
Back pain, fever, night sweats, weight loss
Hypertension, hypokalemia, metabolic acidosis
Weight loss, diarrhea, arthritis, fever, adenopathy
“Strawberry tongue” (Staph. aureus)
Achilles tendon xanthoma
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Muscoal bleeding and prolonged bleeding time
Cutaneous / dermal edema due to connective tissue deposition
Sudden swollen / painful big toe joint, tophi
Situs inversus, chronic sinusitis, bronchiectasis
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
“Strawberry tongue” (Vasculitis)
Red, itchy, swollen rash of nipple areola
Swollen, hard, painful finger joints
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Lucid interval after traumatic brain injury
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Positive anterior “drawer sign”
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Recurrent colds unusual eczema, high serum IgE
Dark purple skin / mouth nodules
Red urine in the morning, fragile RBCs
Rash on palms and soles
Slow, progressive muscle weakness in boys
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Elastic skin, hypermobility of joints
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Resting tremor, rigidity, akinesia, postural instability
Dog or cat bite resulting in infection
Indurated, painful ulcerated genital lesion with exudates
Bone pain, bone enlargement, arthritis
Deep labored breathing / hyperventilation
Polyuria, acidosis, growth failure, electrolyte imbalances
Indurated, non-painful ulcerated genital lesion
Systolic ejection murmur (crescendo-decrescendo)
“Worst headache of my life”
“Waxy” casts with very low urine flow
Dilated cardiomyopathy, edema, polyneuropathy
Smooth, flat, moist white lesions on genitals
Child with fever develops red rash on face that spread to body
Palpable purpura, joint pain, abdominal pain (child)
Swollen gums, mucous leeding, poor wound healing, spots on skin
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
“Cherry-red spot” on macula (hexosaminidase
Toe extension / fanning upon plantar scrape
“Cherry-red spot” on macula (sphingomyelinase)
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Oscillating slow/fast breathing
Chorea, dementia, caudate degeneration
Abdominal pain, ascites, hepatomegaly
Hereditary nephritis, sensorineural hearing loss, cataracts
Unilateral facial dropping invoving forhead
Rash on palms and soles
Pancreatic, pituitary, parathyroid tumors
Bluish line on gingiva
Fever, night sweats, weight loss
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Hypoxemia, polycythemia, hypercapnia
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Painful, raised red lesions on palms and soles
Chronic exercise intolerance with myalgia, fatigue, painful cramps
WBC casts in urine
Chest pain, pericardial effusion / friction rub, persistent fever following MI
“Cherry-red spot” on macula (vascular)
Splinter hemorrhages in fingernails
“Strawberry tongue” (Strep. pyogenes)
Severe RLQ pain with rebound tenderness
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Facial muscle spasm upon tapping
Enlarged, hard left supraclavicular node
Urethritis, conjunctivitis, arthritis in a male
Calf pseudohypertrophy
Painful blue fingers toes, hemolytic anemia
Vascular birthmark (port-wine stain)
Dermatitis, dementia, diarrhea
Hypercoagulability leading to migrating DVTs and vascultitis
Athlete with polycythemia
Streak ovaries, congenital heart disease, horseshoe kidney
Pink complexion, dyspnea, hyperventilation
Dry eyes, dry mouth, arthritis
Vomiting blood following esophagogastric lacerations
Single palm crease
Painful, pale, cold fingers / toes
Green-yellow rings around peripheral cornea
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Fat, female, forty, and fertile
Adrenal hemorrhage, hypotension, DIC
Painful erythematous lesions on palms and soles
Fever, cough, conjunctivitis, coryza, diffuse rash
Continuous “machinery” heart murmur
Painless jaundice
Blue sclera
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Gout, mental retardation, self-mutilating behavior in boy
Skin hyperpigmentation
Pupil accommodates but doesn’t react
Infant with hypoglycemia, failure to thrive, and hepatomegaly

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