USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Dilated cardiomyopathy, edema, polyneuropathy
Pink complexion, dyspnea, hyperventilation
Swollen, hard, painful finger joints
Painful blue fingers toes, hemolytic anemia
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Swollen gums, mucous leeding, poor wound healing, spots on skin
Cutaneous / dermal edema due to connective tissue deposition
Muscoal bleeding and prolonged bleeding time
Hypercoagulability leading to migrating DVTs and vascultitis
Child uses arms to stand up from squat
Male child, recurrent infections, no mature B cells
Achilles tendon xanthoma
Positive anterior “drawer sign”
Fat, female, forty, and fertile
Neonate with arm paralysis following difficult birth
Abdominal pain, ascites, hepatomegaly
Severe jaundice in neonate
Chorea, dementia, caudate degeneration
Blue sclera
Fibrous plaques in soft tissue of penis
Jaundice, RUQ pain, fever
Dry eyes, dry mouth, arthritis
Bluish line on gingiva
Slow, progressive muscle weakness in boys
Enlarged, hard left supraclavicular node
Fever, cough, conjunctivitis, coryza, diffuse rash
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Dermatitis, dementia, diarrhea
Vomiting blood following esophagogastric lacerations
No lactation postpartum, absent menstruation, cold intolerance
Hyperphagia, hypersexuality, hyperorality, hyperdocility
Single palm crease
Vascular birthmark (port-wine stain)
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Continuous “machinery” heart murmur
Hypertension, hypokalemia, metabolic acidosis
Large rash with bull’s-eye appearance
Painful erythematous lesions on palms and soles
Indurated, painful ulcerated genital lesion with exudates
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Splinter hemorrhages in fingernails
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
“Cherry-red spot” on macula (sphingomyelinase)
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Lucid interval after traumatic brain injury
Deep labored breathing / hyperventilation
Adrenal hemorrhage, hypotension, DIC
Red urine in the morning, fragile RBCs
Smooth, flat, moist white lesions on genitals
Painful, pale, cold fingers / toes
Bilateral hilar adenopathy, uveitis
Back pain, fever, night sweats, weight loss
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Dark purple skin / mouth nodules
“Cherry-red spot” on macula (hexosaminidase
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Thyroid and parathyroid tumors, pheochromocytoma
“Strawberry tongue” (Staph. aureus)
Painful, raised red lesions on palms and soles
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Fever, night sweats, weight loss
Oscillating slow/fast breathing
“Cherry-red spot” on macula (vascular)
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Child with fever develops red rash on face that spread to body
“Strawberry tongue” (Strep. pyogenes)
Toe extension / fanning upon plantar scrape
Green-yellow rings around peripheral cornea
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Painless jaundice
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Keratin pearls in a skin biopsy
Indurated, non-painful ulcerated genital lesion
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Palpable purpura, joint pain, abdominal pain (child)
Severe RLQ pain with rebound tenderness
Athlete with polycythemia
Gout, mental retardation, self-mutilating behavior in boy
Red “currant jelly” sputum in alcoholic or diabetic patients
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Urethritis, conjunctivitis, arthritis in a male
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Situs inversus, chronic sinusitis, bronchiectasis
Dog or cat bite resulting in infection
WBC casts in urine
Bone pain, bone enlargement, arthritis
Cold intolerance
Conjugate lateral gaze palsy, horizontal diplopia
Elastic skin, hypermobility of joints
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Retinal hemorrhages with pale centers
Rash on palms and soles
Calf pseudohypertrophy
Sudden swollen / painful big toe joint, tophi
Resting tremor, rigidity, akinesia, postural instability
Weight loss, diarrhea, arthritis, fever, adenopathy
Streak ovaries, congenital heart disease, horseshoe kidney
Pupil accommodates but doesn’t react
Bounding pulses, diastolic heart murmur, head bobbing
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Rash on palms and soles
“Waxy” casts with very low urine flow
“Strawberry tongue” (Vasculitis)
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Systolic ejection murmur (crescendo-decrescendo)
Facial muscle spasm upon tapping
“Worst headache of my life”
Ptosis, miosis, anhydrosis
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Skin hyperpigmentation
Hypoxemia, polycythemia, hypercapnia
Unilateral facial dropping invoving forhead
Pancreatic, pituitary, parathyroid tumors
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Recurrent colds unusual eczema, high serum IgE
Red, itchy, swollen rash of nipple areola
Polyuria, acidosis, growth failure, electrolyte imbalances
Hereditary nephritis, sensorineural hearing loss, cataracts

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