USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Hypertension, hypokalemia, metabolic acidosis
Abdominal pain, ascites, hepatomegaly
Fever, cough, conjunctivitis, coryza, diffuse rash
Adrenal hemorrhage, hypotension, DIC
Keratin pearls in a skin biopsy
Green-yellow rings around peripheral cornea
Vascular birthmark (port-wine stain)
Fibrous plaques in soft tissue of penis
Polyuria, acidosis, growth failure, electrolyte imbalances
Situs inversus, chronic sinusitis, bronchiectasis
Swollen, hard, painful finger joints
Dog or cat bite resulting in infection
Pink complexion, dyspnea, hyperventilation
Large rash with bull’s-eye appearance
Cutaneous / dermal edema due to connective tissue deposition
Fat, female, forty, and fertile
Rash on palms and soles
Hypercoagulability leading to migrating DVTs and vascultitis
Male child, recurrent infections, no mature B cells
Unilateral facial dropping invoving forhead
Jaundice, RUQ pain, fever
WBC casts in urine
Red “currant jelly” sputum in alcoholic or diabetic patients
Splinter hemorrhages in fingernails
Dilated cardiomyopathy, edema, polyneuropathy
Dermatitis, dementia, diarrhea
Elastic skin, hypermobility of joints
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Indurated, painful ulcerated genital lesion with exudates
Athlete with polycythemia
“Strawberry tongue” (Staph. aureus)
Single palm crease
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Painful, pale, cold fingers / toes
Sudden swollen / painful big toe joint, tophi
Resting tremor, rigidity, akinesia, postural instability
Indurated, non-painful ulcerated genital lesion
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Hyperphagia, hypersexuality, hyperorality, hyperdocility
“Cherry-red spot” on macula (sphingomyelinase)
Back pain, fever, night sweats, weight loss
Toe extension / fanning upon plantar scrape
Enlarged, hard left supraclavicular node
“Cherry-red spot” on macula (hexosaminidase
Calf pseudohypertrophy
Painful, raised red lesions on palms and soles
Systolic ejection murmur (crescendo-decrescendo)
Severe jaundice in neonate
Recurrent colds unusual eczema, high serum IgE
Streak ovaries, congenital heart disease, horseshoe kidney
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Conjugate lateral gaze palsy, horizontal diplopia
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Rash on palms and soles
Hereditary nephritis, sensorineural hearing loss, cataracts
“Waxy” casts with very low urine flow
Facial muscle spasm upon tapping
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Blue sclera
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
“Strawberry tongue” (Strep. pyogenes)
Cold intolerance
Bone pain, bone enlargement, arthritis
Neonate with arm paralysis following difficult birth
Dark purple skin / mouth nodules
Red, itchy, swollen rash of nipple areola
Pupil accommodates but doesn’t react
Deep labored breathing / hyperventilation
“Strawberry tongue” (Vasculitis)
Lucid interval after traumatic brain injury
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Bilateral hilar adenopathy, uveitis
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Oscillating slow/fast breathing
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
“Cherry-red spot” on macula (vascular)
Urethritis, conjunctivitis, arthritis in a male
Swollen gums, mucous leeding, poor wound healing, spots on skin
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Bounding pulses, diastolic heart murmur, head bobbing
Pancreatic, pituitary, parathyroid tumors
Hypoxemia, polycythemia, hypercapnia
Thyroid and parathyroid tumors, pheochromocytoma
Bluish line on gingiva
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Severe RLQ pain with rebound tenderness
Painful erythematous lesions on palms and soles
Painful blue fingers toes, hemolytic anemia
Gout, mental retardation, self-mutilating behavior in boy
Retinal hemorrhages with pale centers
Skin hyperpigmentation
Child uses arms to stand up from squat
Achilles tendon xanthoma
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
“Worst headache of my life”
Vomiting blood following esophagogastric lacerations
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Palpable purpura, joint pain, abdominal pain (child)
Child with fever develops red rash on face that spread to body
Dry eyes, dry mouth, arthritis
Continuous “machinery” heart murmur
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Painless jaundice
Weight loss, diarrhea, arthritis, fever, adenopathy
Fever, night sweats, weight loss
Red urine in the morning, fragile RBCs
Positive anterior “drawer sign”
Chorea, dementia, caudate degeneration
No lactation postpartum, absent menstruation, cold intolerance
Ptosis, miosis, anhydrosis
Muscoal bleeding and prolonged bleeding time
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Smooth, flat, moist white lesions on genitals
Slow, progressive muscle weakness in boys

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