USMLE First Aid Rapid Review - Classic Presentations

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Can you name the Classic Presentations of diseases?

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Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Unilateral facial dropping invoving forhead
Male child, recurrent infections, no mature B cells
Green-yellow rings around peripheral cornea
Dog or cat bite resulting in infection
Jaundice, RUQ pain, fever
Adrenal hemorrhage, hypotension, DIC
Bone pain, bone enlargement, arthritis
Bilateral hilar adenopathy, uveitis
Child uses arms to stand up from squat
WBC casts in urine
Recurrent colds unusual eczema, high serum IgE
Rash on palms and soles
Multiple colon polyps, osteomas / soft tissue tumors, impacted / supernumerary teeth
Severe RLQ pain with rebound tenderness
Fever, cough, conjunctivitis, coryza, diffuse rash
Oscillating slow/fast breathing
Ptosis, miosis, anhydrosis
Restrictive cardiomyopathy (juvenile form: cardiomegaly), exercise intolerance
Slow, progressive muscle weakness in boys
Athlete with polycythemia
Hypoxemia, polycythemia, hypercapnia
Pink complexion, dyspnea, hyperventilation
Painless jaundice
Hyperphagia, hypersexuality, hyperorality, hyperdocility
“Worst headache of my life”
Painful, pale, cold fingers / toes
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas, bilateral acoustic neuromas
Blue sclera
Continuous “machinery” heart murmur
Red, itchy, swollen rash of nipple areola
Gout, mental retardation, self-mutilating behavior in boy
Elastic skin, hypermobility of joints
Infant with hypoglycemia, failure to thrive, and hepatomegaly
Dermatitis, dementia, diarrhea
Palpable purpura, joint pain, abdominal pain (child)
Dry eyes, dry mouth, arthritis
Neonate with arm paralysis following difficult birth
Indurated, non-painful ulcerated genital lesion
Renal cell carcinoma, hemangioblastomas, angiomatosis, pheochromocytoma
Small, irregular red spots on buccal / inguinal mucosa with blue-white centers
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, c-ANCA positive
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
Skin hyperpigmentation
Dark purple skin / mouth nodules
Chest pain, pericardial effusion / friction rub, persistent fever following MI
Cold intolerance
Nystagmus, intention tremor, scanning speech, bilateral intranuclear opthalmoplegia
Weight loss, diarrhea, arthritis, fever, adenopathy
Single palm crease
Pancreatic, pituitary, parathyroid tumors
Infant with failure to thrive, hepatosplenomegaly, neurodegeneration
Abdominal pain, ascites, hepatomegaly
Systolic ejection murmur (crescendo-decrescendo)
“Strawberry tongue” (Vasculitis)
Vasculitis from exposure to endotoxin causing glomerular thrombosis
Child with fever develops red rash on face that spread to body
Fibrous plaques in soft tissue of penis
Smooth, flat, moist white lesions on genitals
Café-au-lait spots, Lisch nodules (iris hamartoma), pheochromocytoma, optic gliomas
Fat, female, forty, and fertile
Painful blue fingers toes, hemolytic anemia
Painful erythematous lesions on palms and soles
Hamartamous GI polyps, hyperpigmentation of mouth / feet / hands
Streak ovaries, congenital heart disease, horseshoe kidney
Large rash with bull’s-eye appearance
Short stature, ↑ incidence of tumors / leukemia, aplastic anemia
Pupil accommodates but doesn’t react
Dysphagia (esophageal webs), glossitis, iron deficiency anemia
Chorea, dementia, caudate degeneration
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty
Vascular birthmark (port-wine stain)
Red urine in the morning, fragile RBCs
Hereditary nephritis, sensorineural hearing loss, cataracts
Chronic exercise intolerance with myalgia, fatigue, painful cramps
Cutaneous / dermal edema due to connective tissue deposition
Back pain, fever, night sweats, weight loss
Swollen gums, mucous leeding, poor wound healing, spots on skin
“Strawberry tongue” (Strep. pyogenes)
Situs inversus, chronic sinusitis, bronchiectasis
Keratin pearls in a skin biopsy
Sudden swollen / painful big toe joint, tophi
“Cherry-red spot” on macula (vascular)
Thyroid and parathyroid tumors, pheochromocytoma
Clinical PresentationDiagnosis, Disease, ConditionCharacteristic Info
“Cherry-red spot” on macula (hexosaminidase
Urethritis, conjunctivitis, arthritis in a male
Erytheroderma, lymphadenopathy, hepatosplenomegaly, atypical T cells
“Strawberry tongue” (Staph. aureus)
Bounding pulses, diastolic heart murmur, head bobbing
Bluish line on gingiva
Swollen, hard, painful finger joints
Rapidly progressive leg weakness that ascends (following GI/upper respiratory infection)
Deep labored breathing / hyperventilation
Hepatosplenomegaly, osteoporosis, neurologic symptoms
Painful, raised red lesions on palms and soles
Rash on palms and soles
Fever, night sweats, weight loss
Muscoal bleeding and prolonged bleeding time
“Waxy” casts with very low urine flow
Retinal hemorrhages with pale centers
Enlarged, hard left supraclavicular node
Indurated, painful ulcerated genital lesion with exudates
Vomiting blood following esophagogastric lacerations
Splinter hemorrhages in fingernails
Lucid interval after traumatic brain injury
Infant with microcephaly, rocker-bottom feet, clenched hands, and structural heart defect
Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis, anti-basement membrane antibodies
Calf pseudohypertrophy
Arachnodactyly, lens discoloration, aortic dissection, hyperflexible joints
Positive anterior “drawer sign”
Toe extension / fanning upon plantar scrape
No lactation postpartum, absent menstruation, cold intolerance
Resting tremor, rigidity, akinesia, postural instability
Red “currant jelly” sputum in alcoholic or diabetic patients
Polyuria, acidosis, growth failure, electrolyte imbalances
Achilles tendon xanthoma
Facial muscle spasm upon tapping
Fever, chills, headache, myalgia following antibiotic treatment for syphilis
Hypercoagulability leading to migrating DVTs and vascultitis
Conjugate lateral gaze palsy, horizontal diplopia
Severe jaundice in neonate
Dilated cardiomyopathy, edema, polyneuropathy
“Cherry-red spot” on macula (sphingomyelinase)
Hypertension, hypokalemia, metabolic acidosis

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