| Clues | Enemies |
| Respected scientist who uses four mechanical arms in his experiments | |
| Spiderman's worst enemy. Rides a glider and throws 'Pumpkin' bombs | |
| One-armed scientist who creates a serum from reptilian DNA in hopes of gaining reptile-like regeneration abilities | |
| His cells are spliced with sand molecules and his body becomes a mass of a sand-like substance | |
| Develops a pair of gauntlets capable of throwing powerful vibrational blasts. Wears a gold and brown costume | |
| Wears a dark costume and has all of Spiderman's powers. Knows Spiderman's identity | |
| Has a self-invented anti-gravity pack, wings for faster flying and a birdlike costume | |
| Big game hunter who disdains the use of of guns and bows or arrows and rather defeat animals with his bare hands | |
| Underwent an experimental animal mutation therapy, imbuing him with super-strength, speed, and endurance at the cost of his sanity | |