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Interleukins
Can you name the Interleukins?
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Wombo_Johnson
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Action of the IL
Interleukin
Extra Info
Inhibits Th2 response and induces Th1 response; Activates Macrophages, has antiviral and antitumor properties
also can cause cachexia
Secreted by all T-cells, supports bone marrow growth, acts like GM-CSF
Induces Th2 differentiation. Enhances class switch to IgA. Increases Eosinophils
Necessary for parasitic infection, mucosal membrane protection
Endogenous pyrogen; stimulates production of acute-phase proteins
Causes fever, cachexia from tumors
Endogenous pyrogen; activates endothelium to express adhesion molecules
Causes fever
Major chemotactic factor for neutrophils
C5a and LTB4 are also strong for chemotaxis
Causes septic shock; leaky blood vessels
Also causes cachexia in people with tumors/cancer
Inhibits Th1 response and induces Th2 response; secreted by Regulatory T-cells
TGF-Beta has similar actions involving inflammatory inhibition
Induces Th2 differentiation, Enhances class switch to IgE and IgG
Necessary for Type 1 Hypersensitivity
Induces Th1 differentiation, activates NK cells
Secreted by macrophages
Stimulates growth of Cytotoxic T-cells (also Helper T-cells)
secreted by Th1 cells
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Last Updated: Feb 16, 2017
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