| Event | Date | Extra Info |
| End of First Civil War in Britain. | |
| Start of First Civil War in Britain. | |
| Andrew Marvell is appointed to be John Milton's Assistant in the Secretaryship. | |
| Astronomer and mathematician Johannes Kepler dies. | |
| William Shakespeare dies. | |
| Sir Walter Raleigh is executed. | |
| Theaters in Britain are closed. | |
| Shakespeare's First Folio is published. | |
| The theaters in Britain are reopened. | |
| Jamestown is settled. | |
| The Commonwealth is ended. Start of the reign of Charles II. | |
| Nicolaus Copernicus dies. This same year, his landmark book Concerning the Revolutions of the Celestial Spheres is published. | |
| The Royal Society is founded. | |
| Cervantes's Don Quixote is published. | |
| Oliver Cromwell dies, His son Richard succeeds him as Protector. | |
| Henry VIII's Act of Supremacy. | |
| End of the reign of Henry VIII. Start of the reign of Edward VI. | |
| Descartes' Principia Philosophicae is published. | |
| End of the reign of Mary I. Start of the reign of Elizabeth I. | |
| The King James Bible is published. | |
| Sir Isaac Newton's manifesto Philosophiae Naturalis Principia Mathematica is published. | |