| Last Republican pair | State |
| 1968 - George Murphy and Thomas Kuchel | |
| 2006 - Kit Bond and Jim Talent | |
| 1911 - Thomas Carter and Joseph Dixon | |
| Present - Bob Corker and Lamar Alexander | |
| 1986 - Larry Pressler and James Abdnor | |
| 1954 - Homer Ferguson and Charles Potter | |
| 1976 - James Buckley and Jacob Javits | |
| Present - Thad Cochran and Roger Wicker | |
| 1872 - William Kellogg and Joseph West | |
| 1957 - Joseph McCarthy and Alexander Wiley | |
| 1952 - Henry Cabot Lodge Jr and Leverett Saltonstall | |
| Present - Tom Coburn and Jim Inhofe | |
| 1974 - George Aiken and Robert Stafford | |
| 2006 - Mike DeWine and George Voinovich | |
| Present - Richard Shelby and Jeff Sessions | |
| 2006 - George Allen and John Warner | |
| 1982 - Pete Domenici and Harrison Schmitt | |
| Present - Mike Enzi and John Barrasso | |
| Present - John McCain and Jon Kyl | |
| Present - Dan Coats and Richard Lugar | |
| Present - Mike Crapo and Jim Risch | |
| 1995 - Bob Packwood and Mark Hatfield | |
| 1986 - Daniel Evans and Slade Gorton | |
| 1984 - Chuck Grassley and Roger Jepsen | |
| 1976 - Roman Hruska and Carl Curtis | |