| Accomplishment | Astronaut |
| The first American to fly in space. | |
| The last American to fly a solo NASA mission. | |
| The first American in Earth orbit. | |
| The first American woman in space. | |
| The first American to fly two space missions in different programs. | |
| The pilot of the Apollo 11 command module. | |
| The first Israeli in space. | |
| The first American to perform a 'spacewalk'. | |
| The first African-American to fly in space. | |
| The first female space shuttle commander. | |
| The commander of the ill-fated Apollo 13 mission. | |