NSAIDs and DMARDs

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Can you name the NSAIDs and DMARDs?

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HintDrugClass of Drug
Can reduce the renal excretion of lithium; ~50 hour half life, allowing single daily doseNSAID, Enolic Acid Derivative
Combination of Diclofenac and Misoprostol that provides gastric protectionNSAID, Heteroaryl Acetic Acid Derivative
Recently approved TNF inhibitorDMARD, TNF Inhibitor
Does not affect COX-1; used for osteoarthritis, rheumatoid arthritis, acute pain, and dysmenorrheal; potential cardiovascular problemsNSAID, COX-2 Inhibitor
More potent cyclooxygenase inhibitor than indomethacin and naproxen; used for rheumatoid arthritis, osteoarthritis, etcNSAID, Heteroaryl Acetic Acid Derivative
Competitively inhibits IL-1 binding to the IL-1 receptor; indicated for moderate to severe RA patients who have failed 1 or more DMARDsDMARD, IL-1 Receptor Antagonist
Covalently modifies COX-1 and COX-2, irreversibly inhibiting cyclooxygenase activity; can result in Reyes Syndrome in childrenNSAID, Salicylate
Doses up to 3200 mg/day for rheumatoid arthritis; half-life in plasma is about 2 hoursNSAID, Propionic Acid Derivative
Used for rheumatoid arthritis, mild to moderate ulcerative colitis, and Crohn’s diseaseDMARD
Decrease TNF-alpha levels; indicated for rheumatoid arthritis in patients with inadequate response to other DMARDsDMARD, TNF Inhibitor
Anti-inflammatory and immunosuppressive actions; provide relief until other, slower acting antirheumatic drugs take effectCorticosteroid
Oral pyrimidine synthesis inhibitor; slows progression of mild rheumatoid arthritisDMARD
Inhibits T cell activation, diminishes inflammatory cytokine and TNF secretionDMARD
HintDrugClass of Drug
Short term use for severe pain; approved for parenteral administration; topically useful for inflammation in the eye following surgery or seasonal allergiesNSAID, Heteroaryl Acetic Acid Derivative
One of the more potent COX inhibitors; use for treatment of arthritis and gout; GI irritation common; can cause renal dysfunctionNSAID, Para-aminophenol Derivative
Monoclonal antibody against the IL-6 receptorDMARD
Depletes B cells, leads to decreased cytokines and B/T cell interactionsDMARD
More selective COX-2 inhibitor, though it will also inhibit COX-1; side effects similar to other NSAIDs although may have lower GI effectsNSAID, Enolic Acid Derivative
Inhibits binding of TNF-alpha with its receptors; used in RA and Crohn’s diseaseDMARD, TNF Inhibitor
Antimalarial, second line for mild rheumatoid arthritisDMARD
Weak anti-inflamatory effects; hepatic toxicity; no gastric irritation or bleeding; no effects on plateletsNSAID, Para-aminophenol Derivative
Very commonly used for rheumatoid arthritis; DHFR inhibitor; immunosuppressiveDMARD
Once the primary form of rheumatoid arthritis therapy; produces a gradual reduction of the symptoms of inflammation, does not cureDMARD
Clears soluble and membrane bound TNFDMARD, TNF Inhibitor
Long half-life, ~40 hours allowing a single daily doseNSAID, Propionic Acid Derivative
Half-life around 14 hr allows twice a day dosingNSAID, Propionic Acid Derivative

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