NSAIDs and DMARDs

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Can you name the NSAIDs and DMARDs?

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HintDrugClass of Drug
Covalently modifies COX-1 and COX-2, irreversibly inhibiting cyclooxygenase activity; can result in Reyes Syndrome in childrenNSAID, Salicylate
More potent cyclooxygenase inhibitor than indomethacin and naproxen; used for rheumatoid arthritis, osteoarthritis, etcNSAID, Heteroaryl Acetic Acid Derivative
Clears soluble and membrane bound TNFDMARD, TNF Inhibitor
One of the more potent COX inhibitors; use for treatment of arthritis and gout; GI irritation common; can cause renal dysfunctionNSAID, Para-aminophenol Derivative
Inhibits binding of TNF-alpha with its receptors; used in RA and Crohn’s diseaseDMARD, TNF Inhibitor
Depletes B cells, leads to decreased cytokines and B/T cell interactionsDMARD
Once the primary form of rheumatoid arthritis therapy; produces a gradual reduction of the symptoms of inflammation, does not cureDMARD
Inhibits T cell activation, diminishes inflammatory cytokine and TNF secretionDMARD
Used for rheumatoid arthritis, mild to moderate ulcerative colitis, and Crohn’s diseaseDMARD
Weak anti-inflamatory effects; hepatic toxicity; no gastric irritation or bleeding; no effects on plateletsNSAID, Para-aminophenol Derivative
Anti-inflammatory and immunosuppressive actions; provide relief until other, slower acting antirheumatic drugs take effectCorticosteroid
Decrease TNF-alpha levels; indicated for rheumatoid arthritis in patients with inadequate response to other DMARDsDMARD, TNF Inhibitor
Long half-life, ~40 hours allowing a single daily doseNSAID, Propionic Acid Derivative
HintDrugClass of Drug
Can reduce the renal excretion of lithium; ~50 hour half life, allowing single daily doseNSAID, Enolic Acid Derivative
Short term use for severe pain; approved for parenteral administration; topically useful for inflammation in the eye following surgery or seasonal allergiesNSAID, Heteroaryl Acetic Acid Derivative
Recently approved TNF inhibitorDMARD, TNF Inhibitor
Oral pyrimidine synthesis inhibitor; slows progression of mild rheumatoid arthritisDMARD
Combination of Diclofenac and Misoprostol that provides gastric protectionNSAID, Heteroaryl Acetic Acid Derivative
Doses up to 3200 mg/day for rheumatoid arthritis; half-life in plasma is about 2 hoursNSAID, Propionic Acid Derivative
Competitively inhibits IL-1 binding to the IL-1 receptor; indicated for moderate to severe RA patients who have failed 1 or more DMARDsDMARD, IL-1 Receptor Antagonist
Very commonly used for rheumatoid arthritis; DHFR inhibitor; immunosuppressiveDMARD
Antimalarial, second line for mild rheumatoid arthritisDMARD
Monoclonal antibody against the IL-6 receptorDMARD
Does not affect COX-1; used for osteoarthritis, rheumatoid arthritis, acute pain, and dysmenorrheal; potential cardiovascular problemsNSAID, COX-2 Inhibitor
More selective COX-2 inhibitor, though it will also inhibit COX-1; side effects similar to other NSAIDs although may have lower GI effectsNSAID, Enolic Acid Derivative
Half-life around 14 hr allows twice a day dosingNSAID, Propionic Acid Derivative

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Created Oct 4, 2010ReportNominate
Tags:class, dard, drug