Lin Day 1

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Can you name the Lin Day 1?

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use the aPTT to measure the drug use
A vit K dependent serine protease that is activated by thrombin to APC
The effects of WISN are caused by a decrease in activity of this protein
these blood disorders are treated by anticoagulants
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
WISN
the oral standard long term therapy
clopidogrel and ticlopidine act on this receptor
DTI used for HIT, beware of liver, increases INRs
enoxaparin, dalteparin, and tinzaparin are types of this drug
Direct Thrombin Inhibitor, an oral prodrug
This occurs if heparin is given intramuscularly
This LMWH is administered in mg, as opposed to anti factor Xa units
isolated from leech saliva, bivalent irreversible thrombin inhibitor
if the pt has HIT, switch to this drug
recombinant form of hirudin used for HIT, beware of renal insufficiency
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Factor X
Serine protease inhibitor that inhibits plasmin
This parenterally administered drug should not be used intramuscularly
Factor IX
abciximab and eptifibatide and tirofiban act on this receptor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor VIII
This proteins free form acts as a cofactor to protein C
Factor VII
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a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
heparin should not be given to pregnant or breast feeding because of this solution
this antagonist is used to reverse heparin
UFH
This racemic mixture has a long halflife and has 100% bioavailability
Factor IV
Low molecular weight heparin inhibits this factor
this enzyme degrades many blood plasma proteins, most notably, the clot
heparin can clear lipemia by increasing the level of this enzyme
Factor I
allergy, alopecia, and osteoporosis are secondary side effects of this drug
ATIII inactivates these 3 clotting factors (answer in numerical order)
These three bivalent DTIs also bind to the substrate site
heparin's half life in hours
synthetic form of heparin
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
These proteins are endogenous anticoagulants
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Factor II
This vitamin K antagonist inhibits epoxide reductase
HIT
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
These factors facilitate clotting
these vitamin facilitate clotting
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
irudin and gatro are suffixes for this class
Serine protease inhibitor that inactivates clotting factors
Long half life, low side effects, less frequent dosing are traits of this heparin modification

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