Lin Day 1

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Can you name the Lin Day 1?

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isolated from leech saliva, bivalent irreversible thrombin inhibitor
Serine protease inhibitor that inactivates clotting factors
WISN
Factor X
these vitamin facilitate clotting
Factor IX
abciximab and eptifibatide and tirofiban act on this receptor
irudin and gatro are suffixes for this class
A vit K dependent serine protease that is activated by thrombin to APC
This occurs if heparin is given intramuscularly
These proteins are endogenous anticoagulants
heparin's half life in hours
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
HIT
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Factor II
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
synthetic form of heparin
this enzyme degrades many blood plasma proteins, most notably, the clot
The effects of WISN are caused by a decrease in activity of this protein
This proteins free form acts as a cofactor to protein C
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
the oral standard long term therapy
if the pt has HIT, switch to this drug
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
enoxaparin, dalteparin, and tinzaparin are types of this drug
use the aPTT to measure the drug use
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Direct Thrombin Inhibitor, an oral prodrug
Factor IV
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
These three bivalent DTIs also bind to the substrate site
Factor VIII
Factor I
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This vitamin K antagonist inhibits epoxide reductase
heparin should not be given to pregnant or breast feeding because of this solution
This parenterally administered drug should not be used intramuscularly
DTI used for HIT, beware of liver, increases INRs
Factor VII
Low molecular weight heparin inhibits this factor
This LMWH is administered in mg, as opposed to anti factor Xa units
allergy, alopecia, and osteoporosis are secondary side effects of this drug
clopidogrel and ticlopidine act on this receptor
Serine protease inhibitor that inhibits plasmin
These factors facilitate clotting
ATIII inactivates these 3 clotting factors (answer in numerical order)
Long half life, low side effects, less frequent dosing are traits of this heparin modification
recombinant form of hirudin used for HIT, beware of renal insufficiency
this antagonist is used to reverse heparin
This racemic mixture has a long halflife and has 100% bioavailability
UFH
heparin can clear lipemia by increasing the level of this enzyme
these blood disorders are treated by anticoagulants
the famous indirect thrombin inhibitor, can induce thrombocytopenia

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Created Nov 24, 2010ReportNominate
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