Lin Day 1

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Can you name the Lin Day 1?

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abciximab and eptifibatide and tirofiban act on this receptor
clopidogrel and ticlopidine act on this receptor
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
ATIII inactivates these 3 clotting factors (answer in numerical order)
These proteins are endogenous anticoagulants
A vit K dependent serine protease that is activated by thrombin to APC
Low molecular weight heparin inhibits this factor
These factors facilitate clotting
irudin and gatro are suffixes for this class
This racemic mixture has a long halflife and has 100% bioavailability
Factor II
isolated from leech saliva, bivalent irreversible thrombin inhibitor
these vitamin facilitate clotting
These three bivalent DTIs also bind to the substrate site
if the pt has HIT, switch to this drug
recombinant form of hirudin used for HIT, beware of renal insufficiency
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
The effects of WISN are caused by a decrease in activity of this protein
This proteins free form acts as a cofactor to protein C
Direct Thrombin Inhibitor, an oral prodrug
Factor IX
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
This parenterally administered drug should not be used intramuscularly
heparin should not be given to pregnant or breast feeding because of this solution
synthetic form of heparin
heparin's half life in hours
This occurs if heparin is given intramuscularly
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
these blood disorders are treated by anticoagulants
use the aPTT to measure the drug use
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Factor X
this enzyme degrades many blood plasma proteins, most notably, the clot
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Serine protease inhibitor that inhibits plasmin
the oral standard long term therapy
heparin can clear lipemia by increasing the level of this enzyme
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Factor VIII
Factor IV
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
This LMWH is administered in mg, as opposed to anti factor Xa units
Factor VII
Factor I
enoxaparin, dalteparin, and tinzaparin are types of this drug
Serine protease inhibitor that inactivates clotting factors
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Long half life, low side effects, less frequent dosing are traits of this heparin modification
This vitamin K antagonist inhibits epoxide reductase
this antagonist is used to reverse heparin
DTI used for HIT, beware of liver, increases INRs
the famous indirect thrombin inhibitor, can induce thrombocytopenia

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Created Nov 24, 2010ReportNominate