Lin Day 1

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Can you name the Lin Day 1?

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this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
enoxaparin, dalteparin, and tinzaparin are types of this drug
A vit K dependent serine protease that is activated by thrombin to APC
recombinant form of hirudin used for HIT, beware of renal insufficiency
DTI used for HIT, beware of liver, increases INRs
These factors facilitate clotting
use the aPTT to measure the drug use
These proteins are endogenous anticoagulants
irudin and gatro are suffixes for this class
Direct Thrombin Inhibitor, an oral prodrug
clopidogrel and ticlopidine act on this receptor
Low molecular weight heparin inhibits this factor
Factor VII
Factor II
The effects of WISN are caused by a decrease in activity of this protein
Factor VIII
This racemic mixture has a long halflife and has 100% bioavailability
allergy, alopecia, and osteoporosis are secondary side effects of this drug
heparin's half life in hours
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this antagonist is used to reverse heparin
Factor I
These three bivalent DTIs also bind to the substrate site
the oral standard long term therapy
This vitamin K antagonist inhibits epoxide reductase
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
the famous indirect thrombin inhibitor, can induce thrombocytopenia
heparin can clear lipemia by increasing the level of this enzyme
Factor X
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
these vitamin facilitate clotting
This occurs if heparin is given intramuscularly
Factor IX
ATIII inactivates these 3 clotting factors (answer in numerical order)
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Long half life, low side effects, less frequent dosing are traits of this heparin modification
if the pt has HIT, switch to this drug
Factor IV
these blood disorders are treated by anticoagulants
This LMWH is administered in mg, as opposed to anti factor Xa units
This proteins free form acts as a cofactor to protein C
This parenterally administered drug should not be used intramuscularly
heparin should not be given to pregnant or breast feeding because of this solution
abciximab and eptifibatide and tirofiban act on this receptor
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
this enzyme degrades many blood plasma proteins, most notably, the clot
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
synthetic form of heparin
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Serine protease inhibitor that inactivates clotting factors
Serine protease inhibitor that inhibits plasmin

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