Lin Day 1

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Can you name the Lin Day 1?

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UFH
This occurs if heparin is given intramuscularly
Serine protease inhibitor that inactivates clotting factors
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
allergy, alopecia, and osteoporosis are secondary side effects of this drug
heparin should not be given to pregnant or breast feeding because of this solution
Long half life, low side effects, less frequent dosing are traits of this heparin modification
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
heparin can clear lipemia by increasing the level of this enzyme
A vit K dependent serine protease that is activated by thrombin to APC
if the pt has HIT, switch to this drug
isolated from leech saliva, bivalent irreversible thrombin inhibitor
irudin and gatro are suffixes for this class
Factor VII
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
these blood disorders are treated by anticoagulants
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Factor IV
This proteins free form acts as a cofactor to protein C
These factors facilitate clotting
This vitamin K antagonist inhibits epoxide reductase
synthetic form of heparin
Factor VIII
ATIII inactivates these 3 clotting factors (answer in numerical order)
the famous indirect thrombin inhibitor, can induce thrombocytopenia
the oral standard long term therapy
This parenterally administered drug should not be used intramuscularly
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
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this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
clopidogrel and ticlopidine act on this receptor
abciximab and eptifibatide and tirofiban act on this receptor
These three bivalent DTIs also bind to the substrate site
this antagonist is used to reverse heparin
This racemic mixture has a long halflife and has 100% bioavailability
Direct Thrombin Inhibitor, an oral prodrug
recombinant form of hirudin used for HIT, beware of renal insufficiency
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Factor IX
DTI used for HIT, beware of liver, increases INRs
Factor II
use the aPTT to measure the drug use
The effects of WISN are caused by a decrease in activity of this protein
Factor I
Serine protease inhibitor that inhibits plasmin
WISN
These proteins are endogenous anticoagulants
This LMWH is administered in mg, as opposed to anti factor Xa units
enoxaparin, dalteparin, and tinzaparin are types of this drug
HIT
these vitamin facilitate clotting
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
this enzyme degrades many blood plasma proteins, most notably, the clot
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
heparin's half life in hours
Low molecular weight heparin inhibits this factor
Factor X

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Created Nov 24, 2010ReportNominate
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