Lin Day 1

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heparin can clear lipemia by increasing the level of this enzyme
synthetic form of heparin
These proteins are endogenous anticoagulants
Low molecular weight heparin inhibits this factor
this antagonist is used to reverse heparin
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Serine protease inhibitor that inhibits plasmin
A vit K dependent serine protease that is activated by thrombin to APC
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
UFH
if the pt has HIT, switch to this drug
Serine protease inhibitor that inactivates clotting factors
Factor II
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Factor IV
This occurs if heparin is given intramuscularly
HIT
heparin should not be given to pregnant or breast feeding because of this solution
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
This parenterally administered drug should not be used intramuscularly
These factors facilitate clotting
these vitamin facilitate clotting
the oral standard long term therapy
This racemic mixture has a long halflife and has 100% bioavailability
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
WISN
irudin and gatro are suffixes for this class
Factor VIII
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The effects of WISN are caused by a decrease in activity of this protein
Factor I
ATIII inactivates these 3 clotting factors (answer in numerical order)
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
abciximab and eptifibatide and tirofiban act on this receptor
This vitamin K antagonist inhibits epoxide reductase
Factor IX
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
DTI used for HIT, beware of liver, increases INRs
isolated from leech saliva, bivalent irreversible thrombin inhibitor
use the aPTT to measure the drug use
Long half life, low side effects, less frequent dosing are traits of this heparin modification
this enzyme degrades many blood plasma proteins, most notably, the clot
These three bivalent DTIs also bind to the substrate site
Factor X
Factor VII
This proteins free form acts as a cofactor to protein C
enoxaparin, dalteparin, and tinzaparin are types of this drug
heparin's half life in hours
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
these blood disorders are treated by anticoagulants
clopidogrel and ticlopidine act on this receptor
Direct Thrombin Inhibitor, an oral prodrug
recombinant form of hirudin used for HIT, beware of renal insufficiency
This LMWH is administered in mg, as opposed to anti factor Xa units

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