Lin Day 1

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Can you name the Lin Day 1?

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the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor II
the oral standard long term therapy
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
irudin and gatro are suffixes for this class
clopidogrel and ticlopidine act on this receptor
Factor X
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Factor IV
Serine protease inhibitor that inhibits plasmin
heparin can clear lipemia by increasing the level of this enzyme
Factor VIII
isolated from leech saliva, bivalent irreversible thrombin inhibitor
heparin should not be given to pregnant or breast feeding because of this solution
Factor IX
ATIII inactivates these 3 clotting factors (answer in numerical order)
Direct Thrombin Inhibitor, an oral prodrug
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Factor I
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
allergy, alopecia, and osteoporosis are secondary side effects of this drug
UFH
Serine protease inhibitor that inactivates clotting factors
Long half life, low side effects, less frequent dosing are traits of this heparin modification
abciximab and eptifibatide and tirofiban act on this receptor
these vitamin facilitate clotting
Factor VII
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This occurs if heparin is given intramuscularly
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
HIT
The effects of WISN are caused by a decrease in activity of this protein
heparin's half life in hours
A vit K dependent serine protease that is activated by thrombin to APC
recombinant form of hirudin used for HIT, beware of renal insufficiency
enoxaparin, dalteparin, and tinzaparin are types of this drug
This proteins free form acts as a cofactor to protein C
These factors facilitate clotting
these blood disorders are treated by anticoagulants
This vitamin K antagonist inhibits epoxide reductase
Low molecular weight heparin inhibits this factor
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
synthetic form of heparin
These three bivalent DTIs also bind to the substrate site
this enzyme degrades many blood plasma proteins, most notably, the clot
This racemic mixture has a long halflife and has 100% bioavailability
this antagonist is used to reverse heparin
if the pt has HIT, switch to this drug
This LMWH is administered in mg, as opposed to anti factor Xa units
use the aPTT to measure the drug use
DTI used for HIT, beware of liver, increases INRs
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
These proteins are endogenous anticoagulants
This parenterally administered drug should not be used intramuscularly
WISN

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Created Nov 24, 2010ReportNominate
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