Lin Day 1

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Can you name the Lin Day 1?

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heparin's half life in hours
synthetic form of heparin
use the aPTT to measure the drug use
the oral standard long term therapy
Factor X
Long half life, low side effects, less frequent dosing are traits of this heparin modification
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Low molecular weight heparin inhibits this factor
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
enoxaparin, dalteparin, and tinzaparin are types of this drug
DTI used for HIT, beware of liver, increases INRs
these blood disorders are treated by anticoagulants
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Factor IV
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
This racemic mixture has a long halflife and has 100% bioavailability
This parenterally administered drug should not be used intramuscularly
if the pt has HIT, switch to this drug
The effects of WISN are caused by a decrease in activity of this protein
Factor IX
this enzyme degrades many blood plasma proteins, most notably, the clot
This LMWH is administered in mg, as opposed to anti factor Xa units
This proteins free form acts as a cofactor to protein C
This vitamin K antagonist inhibits epoxide reductase
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
recombinant form of hirudin used for HIT, beware of renal insufficiency
these vitamin facilitate clotting
These three bivalent DTIs also bind to the substrate site
abciximab and eptifibatide and tirofiban act on this receptor
heparin should not be given to pregnant or breast feeding because of this solution
Direct Thrombin Inhibitor, an oral prodrug
Factor VIII
irudin and gatro are suffixes for this class
These proteins are endogenous anticoagulants
the famous indirect thrombin inhibitor, can induce thrombocytopenia
isolated from leech saliva, bivalent irreversible thrombin inhibitor
This occurs if heparin is given intramuscularly
clopidogrel and ticlopidine act on this receptor
Serine protease inhibitor that inhibits plasmin
A vit K dependent serine protease that is activated by thrombin to APC
ATIII inactivates these 3 clotting factors (answer in numerical order)
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Factor VII
These factors facilitate clotting
Factor II
Factor I
this antagonist is used to reverse heparin
heparin can clear lipemia by increasing the level of this enzyme
Serine protease inhibitor that inactivates clotting factors

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Created Nov 24, 2010ReportNominate