Lin Day 1

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Can you name the Lin Day 1?

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heparin can clear lipemia by increasing the level of this enzyme
This racemic mixture has a long halflife and has 100% bioavailability
irudin and gatro are suffixes for this class
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
recombinant form of hirudin used for HIT, beware of renal insufficiency
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Serine protease inhibitor that inhibits plasmin
This occurs if heparin is given intramuscularly
WISN
heparin should not be given to pregnant or breast feeding because of this solution
clopidogrel and ticlopidine act on this receptor
Factor X
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
enoxaparin, dalteparin, and tinzaparin are types of this drug
isolated from leech saliva, bivalent irreversible thrombin inhibitor
DTI used for HIT, beware of liver, increases INRs
Factor VII
Factor I
Serine protease inhibitor that inactivates clotting factors
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
ATIII inactivates these 3 clotting factors (answer in numerical order)
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Factor IV
heparin's half life in hours
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
allergy, alopecia, and osteoporosis are secondary side effects of this drug
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Direct Thrombin Inhibitor, an oral prodrug
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A vit K dependent serine protease that is activated by thrombin to APC
Long half life, low side effects, less frequent dosing are traits of this heparin modification
if the pt has HIT, switch to this drug
this antagonist is used to reverse heparin
Factor IX
Low molecular weight heparin inhibits this factor
synthetic form of heparin
These factors facilitate clotting
These three bivalent DTIs also bind to the substrate site
This vitamin K antagonist inhibits epoxide reductase
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
HIT
this enzyme degrades many blood plasma proteins, most notably, the clot
use the aPTT to measure the drug use
This proteins free form acts as a cofactor to protein C
Factor II
This LMWH is administered in mg, as opposed to anti factor Xa units
Factor VIII
these blood disorders are treated by anticoagulants
UFH
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
These proteins are endogenous anticoagulants
the oral standard long term therapy
This parenterally administered drug should not be used intramuscularly
abciximab and eptifibatide and tirofiban act on this receptor
these vitamin facilitate clotting
the famous indirect thrombin inhibitor, can induce thrombocytopenia
The effects of WISN are caused by a decrease in activity of this protein

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Created Nov 24, 2010ReportNominate
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