Lin Day 1

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Can you name the Lin Day 1?

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these vitamin facilitate clotting
Factor VIII
Serine protease inhibitor that inhibits plasmin
Serine protease inhibitor that inactivates clotting factors
ATIII inactivates these 3 clotting factors (answer in numerical order)
Factor IX
The effects of WISN are caused by a decrease in activity of this protein
Low molecular weight heparin inhibits this factor
DTI used for HIT, beware of liver, increases INRs
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Factor X
A vit K dependent serine protease that is activated by thrombin to APC
This occurs if heparin is given intramuscularly
this enzyme degrades many blood plasma proteins, most notably, the clot
recombinant form of hirudin used for HIT, beware of renal insufficiency
if the pt has HIT, switch to this drug
heparin's half life in hours
abciximab and eptifibatide and tirofiban act on this receptor
use the aPTT to measure the drug use
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor I
this antagonist is used to reverse heparin
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
allergy, alopecia, and osteoporosis are secondary side effects of this drug
This parenterally administered drug should not be used intramuscularly
these blood disorders are treated by anticoagulants
Direct Thrombin Inhibitor, an oral prodrug
Factor II
the oral standard long term therapy
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This proteins free form acts as a cofactor to protein C
These three bivalent DTIs also bind to the substrate site
enoxaparin, dalteparin, and tinzaparin are types of this drug
heparin should not be given to pregnant or breast feeding because of this solution
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
isolated from leech saliva, bivalent irreversible thrombin inhibitor
heparin can clear lipemia by increasing the level of this enzyme
Factor VII
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
These proteins are endogenous anticoagulants
This vitamin K antagonist inhibits epoxide reductase
These factors facilitate clotting
irudin and gatro are suffixes for this class
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
This LMWH is administered in mg, as opposed to anti factor Xa units
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Long half life, low side effects, less frequent dosing are traits of this heparin modification
This racemic mixture has a long halflife and has 100% bioavailability
clopidogrel and ticlopidine act on this receptor
Factor IV
synthetic form of heparin

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Created Nov 24, 2010ReportNominate