Lin Day 1

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Can you name the Lin Day 1?

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recombinant form of hirudin used for HIT, beware of renal insufficiency
these blood disorders are treated by anticoagulants
isolated from leech saliva, bivalent irreversible thrombin inhibitor
These proteins are endogenous anticoagulants
These three bivalent DTIs also bind to the substrate site
Direct Thrombin Inhibitor, an oral prodrug
ATIII inactivates these 3 clotting factors (answer in numerical order)
This LMWH is administered in mg, as opposed to anti factor Xa units
this antagonist is used to reverse heparin
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
irudin and gatro are suffixes for this class
if the pt has HIT, switch to this drug
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
heparin should not be given to pregnant or breast feeding because of this solution
heparin's half life in hours
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Factor I
heparin can clear lipemia by increasing the level of this enzyme
synthetic form of heparin
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
use the aPTT to measure the drug use
UFH
WISN
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This proteins free form acts as a cofactor to protein C
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Factor VII
these vitamin facilitate clotting
Factor VIII
A vit K dependent serine protease that is activated by thrombin to APC
DTI used for HIT, beware of liver, increases INRs
This occurs if heparin is given intramuscularly
HIT
This racemic mixture has a long halflife and has 100% bioavailability
Serine protease inhibitor that inactivates clotting factors
Serine protease inhibitor that inhibits plasmin
Factor II
The effects of WISN are caused by a decrease in activity of this protein
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
the oral standard long term therapy
this enzyme degrades many blood plasma proteins, most notably, the clot
This vitamin K antagonist inhibits epoxide reductase
Factor IX
This parenterally administered drug should not be used intramuscularly
enoxaparin, dalteparin, and tinzaparin are types of this drug
Low molecular weight heparin inhibits this factor
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Factor X
abciximab and eptifibatide and tirofiban act on this receptor
Factor IV
Long half life, low side effects, less frequent dosing are traits of this heparin modification
These factors facilitate clotting
clopidogrel and ticlopidine act on this receptor

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Created Nov 24, 2010ReportNominate
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