Lin Day 1

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Can you name the Lin Day 1?

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the oral standard long term therapy
clopidogrel and ticlopidine act on this receptor
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Factor II
Factor VII
Low molecular weight heparin inhibits this factor
Long half life, low side effects, less frequent dosing are traits of this heparin modification
Factor I
Factor VIII
enoxaparin, dalteparin, and tinzaparin are types of this drug
recombinant form of hirudin used for HIT, beware of renal insufficiency
heparin can clear lipemia by increasing the level of this enzyme
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Factor X
Factor IV
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
These three bivalent DTIs also bind to the substrate site
Direct Thrombin Inhibitor, an oral prodrug
This vitamin K antagonist inhibits epoxide reductase
this antagonist is used to reverse heparin
these blood disorders are treated by anticoagulants
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
A vit K dependent serine protease that is activated by thrombin to APC
allergy, alopecia, and osteoporosis are secondary side effects of this drug
These factors facilitate clotting
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
ATIII inactivates these 3 clotting factors (answer in numerical order)
This occurs if heparin is given intramuscularly
irudin and gatro are suffixes for this class
This racemic mixture has a long halflife and has 100% bioavailability
These proteins are endogenous anticoagulants
Serine protease inhibitor that inhibits plasmin
use the aPTT to measure the drug use
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
synthetic form of heparin
if the pt has HIT, switch to this drug
heparin should not be given to pregnant or breast feeding because of this solution
Factor IX
This LMWH is administered in mg, as opposed to anti factor Xa units
This proteins free form acts as a cofactor to protein C
abciximab and eptifibatide and tirofiban act on this receptor
Serine protease inhibitor that inactivates clotting factors
this enzyme degrades many blood plasma proteins, most notably, the clot
heparin's half life in hours
these vitamin facilitate clotting
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
DTI used for HIT, beware of liver, increases INRs
The effects of WISN are caused by a decrease in activity of this protein
This parenterally administered drug should not be used intramuscularly
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor

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