Science / Lin Day 1

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Can you name the Lin Day 1?

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This racemic mixture has a long halflife and has 100% bioavailability
Direct Thrombin Inhibitor, an oral prodrug
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
This occurs if heparin is given intramuscularly
A vit K dependent serine protease that is activated by thrombin to APC
This proteins free form acts as a cofactor to protein C
heparin should not be given to pregnant or breast feeding because of this solution
irudin and gatro are suffixes for this class
this antagonist is used to reverse heparin
The effects of WISN are caused by a decrease in activity of this protein
HIT
use the aPTT to measure the drug use
isolated from leech saliva, bivalent irreversible thrombin inhibitor
These proteins are endogenous anticoagulants
Low molecular weight heparin inhibits this factor
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Factor VII
This vitamin K antagonist inhibits epoxide reductase
abciximab and eptifibatide and tirofiban act on this receptor
Factor I
Factor X
synthetic form of heparin
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
heparin can clear lipemia by increasing the level of this enzyme
heparin's half life in hours
enoxaparin, dalteparin, and tinzaparin are types of this drug
Factor II
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the oral standard long term therapy
clopidogrel and ticlopidine act on this receptor
allergy, alopecia, and osteoporosis are secondary side effects of this drug
these vitamin facilitate clotting
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
UFH
these blood disorders are treated by anticoagulants
ATIII inactivates these 3 clotting factors (answer in numerical order)
if the pt has HIT, switch to this drug
These factors facilitate clotting
Serine protease inhibitor that inactivates clotting factors
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Factor VIII
recombinant form of hirudin used for HIT, beware of renal insufficiency
Factor IX
These three bivalent DTIs also bind to the substrate site
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
DTI used for HIT, beware of liver, increases INRs
Factor IV
Serine protease inhibitor that inhibits plasmin
this enzyme degrades many blood plasma proteins, most notably, the clot
WISN
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
This parenterally administered drug should not be used intramuscularly
This LMWH is administered in mg, as opposed to anti factor Xa units
Long half life, low side effects, less frequent dosing are traits of this heparin modification
the famous indirect thrombin inhibitor, can induce thrombocytopenia

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