Lin Day 1

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Can you name the Lin Day 1?

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heparin's half life in hours
irudin and gatro are suffixes for this class
DTI used for HIT, beware of liver, increases INRs
Serine protease inhibitor that inactivates clotting factors
abciximab and eptifibatide and tirofiban act on this receptor
These factors facilitate clotting
allergy, alopecia, and osteoporosis are secondary side effects of this drug
Factor X
this antagonist is used to reverse heparin
heparin can clear lipemia by increasing the level of this enzyme
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
This occurs if heparin is given intramuscularly
if the pt has HIT, switch to this drug
Factor VII
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
The effects of WISN are caused by a decrease in activity of this protein
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
use the aPTT to measure the drug use
these blood disorders are treated by anticoagulants
the oral standard long term therapy
These proteins are endogenous anticoagulants
heparin should not be given to pregnant or breast feeding because of this solution
recombinant form of hirudin used for HIT, beware of renal insufficiency
Factor IV
isolated from leech saliva, bivalent irreversible thrombin inhibitor
ATIII inactivates these 3 clotting factors (answer in numerical order)
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Serine protease inhibitor that inhibits plasmin
This proteins free form acts as a cofactor to protein C
Factor VIII
This vitamin K antagonist inhibits epoxide reductase
synthetic form of heparin
This parenterally administered drug should not be used intramuscularly
Low molecular weight heparin inhibits this factor
Long half life, low side effects, less frequent dosing are traits of this heparin modification
These three bivalent DTIs also bind to the substrate site
Factor I
enoxaparin, dalteparin, and tinzaparin are types of this drug
this enzyme degrades many blood plasma proteins, most notably, the clot
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Direct Thrombin Inhibitor, an oral prodrug
This racemic mixture has a long halflife and has 100% bioavailability
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Factor II
the famous indirect thrombin inhibitor, can induce thrombocytopenia
A vit K dependent serine protease that is activated by thrombin to APC
these vitamin facilitate clotting
This LMWH is administered in mg, as opposed to anti factor Xa units
clopidogrel and ticlopidine act on this receptor
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Factor IX

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Created Nov 24, 2010ReportNominate