Lin Day 1

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Can you name the Lin Day 1?

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Direct Thrombin Inhibitor, an oral prodrug
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
enoxaparin, dalteparin, and tinzaparin are types of this drug
heparin's half life in hours
Factor I
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
This racemic mixture has a long halflife and has 100% bioavailability
Factor VII
clopidogrel and ticlopidine act on this receptor
These three bivalent DTIs also bind to the substrate site
Factor II
Serine protease inhibitor that inactivates clotting factors
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
heparin should not be given to pregnant or breast feeding because of this solution
allergy, alopecia, and osteoporosis are secondary side effects of this drug
synthetic form of heparin
these blood disorders are treated by anticoagulants
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Factor IV
A vit K dependent serine protease that is activated by thrombin to APC
Factor X
these vitamin facilitate clotting
These factors facilitate clotting
Low molecular weight heparin inhibits this factor
if the pt has HIT, switch to this drug
Factor VIII
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Long half life, low side effects, less frequent dosing are traits of this heparin modification
These proteins are endogenous anticoagulants
This parenterally administered drug should not be used intramuscularly
this enzyme degrades many blood plasma proteins, most notably, the clot
irudin and gatro are suffixes for this class
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
This LMWH is administered in mg, as opposed to anti factor Xa units
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This occurs if heparin is given intramuscularly
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
recombinant form of hirudin used for HIT, beware of renal insufficiency
This proteins free form acts as a cofactor to protein C
heparin can clear lipemia by increasing the level of this enzyme
isolated from leech saliva, bivalent irreversible thrombin inhibitor
use the aPTT to measure the drug use
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this antagonist is used to reverse heparin
This vitamin K antagonist inhibits epoxide reductase
The effects of WISN are caused by a decrease in activity of this protein
Factor IX
the oral standard long term therapy
ATIII inactivates these 3 clotting factors (answer in numerical order)
abciximab and eptifibatide and tirofiban act on this receptor
Serine protease inhibitor that inhibits plasmin
DTI used for HIT, beware of liver, increases INRs

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Created Nov 24, 2010ReportNominate