Science / Lin Day 1

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Can you name the Lin Day 1?

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A vit K dependent serine protease that is activated by thrombin to APC
The effects of WISN are caused by a decrease in activity of this protein
recombinant form of hirudin used for HIT, beware of renal insufficiency
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
this enzyme degrades many blood plasma proteins, most notably, the clot
This occurs if heparin is given intramuscularly
heparin's half life in hours
these vitamin facilitate clotting
This vitamin K antagonist inhibits epoxide reductase
ATIII inactivates these 3 clotting factors (answer in numerical order)
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
use the aPTT to measure the drug use
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This parenterally administered drug should not be used intramuscularly
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Factor II
This proteins free form acts as a cofactor to protein C
allergy, alopecia, and osteoporosis are secondary side effects of this drug
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Factor IV
These proteins are endogenous anticoagulants
synthetic form of heparin
abciximab and eptifibatide and tirofiban act on this receptor
Long half life, low side effects, less frequent dosing are traits of this heparin modification
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Factor X
irudin and gatro are suffixes for this class
These factors facilitate clotting
the oral standard long term therapy
enoxaparin, dalteparin, and tinzaparin are types of this drug
These three bivalent DTIs also bind to the substrate site
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
if the pt has HIT, switch to this drug
clopidogrel and ticlopidine act on this receptor
This LMWH is administered in mg, as opposed to anti factor Xa units
Direct Thrombin Inhibitor, an oral prodrug
Factor I
Low molecular weight heparin inhibits this factor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
this antagonist is used to reverse heparin
these blood disorders are treated by anticoagulants
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Factor VIII
Serine protease inhibitor that inactivates clotting factors
DTI used for HIT, beware of liver, increases INRs
Serine protease inhibitor that inhibits plasmin
This racemic mixture has a long halflife and has 100% bioavailability
heparin should not be given to pregnant or breast feeding because of this solution
Factor VII
Factor IX
heparin can clear lipemia by increasing the level of this enzyme
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor

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