Lin Day 1

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Can you name the Lin Day 1?

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The effects of WISN are caused by a decrease in activity of this protein
These factors facilitate clotting
Factor IX
Factor X
abciximab and eptifibatide and tirofiban act on this receptor
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
allergy, alopecia, and osteoporosis are secondary side effects of this drug
these blood disorders are treated by anticoagulants
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Factor VIII
Factor IV
the famous indirect thrombin inhibitor, can induce thrombocytopenia
this enzyme degrades many blood plasma proteins, most notably, the clot
the oral standard long term therapy
This proteins free form acts as a cofactor to protein C
recombinant form of hirudin used for HIT, beware of renal insufficiency
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
Low molecular weight heparin inhibits this factor
Factor I
synthetic form of heparin
these vitamin facilitate clotting
Factor VII
if the pt has HIT, switch to this drug
These proteins are endogenous anticoagulants
This racemic mixture has a long halflife and has 100% bioavailability
UFH
this antagonist is used to reverse heparin
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Long half life, low side effects, less frequent dosing are traits of this heparin modification
isolated from leech saliva, bivalent irreversible thrombin inhibitor
irudin and gatro are suffixes for this class
heparin can clear lipemia by increasing the level of this enzyme
clopidogrel and ticlopidine act on this receptor
These three bivalent DTIs also bind to the substrate site
Direct Thrombin Inhibitor, an oral prodrug
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
use the aPTT to measure the drug use
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
heparin's half life in hours
Serine protease inhibitor that inhibits plasmin
DTI used for HIT, beware of liver, increases INRs
WISN
This vitamin K antagonist inhibits epoxide reductase
ATIII inactivates these 3 clotting factors (answer in numerical order)
A vit K dependent serine protease that is activated by thrombin to APC
This parenterally administered drug should not be used intramuscularly
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
enoxaparin, dalteparin, and tinzaparin are types of this drug
heparin should not be given to pregnant or breast feeding because of this solution
This LMWH is administered in mg, as opposed to anti factor Xa units
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
HIT
Serine protease inhibitor that inactivates clotting factors
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
This occurs if heparin is given intramuscularly
Factor II

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Created Nov 24, 2010ReportNominate
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