Lin Day 1

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Can you name the Lin Day 1?

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This occurs if heparin is given intramuscularly
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Direct Thrombin Inhibitor, an oral prodrug
Factor X
heparin's half life in hours
Factor IX
heparin can clear lipemia by increasing the level of this enzyme
This proteins free form acts as a cofactor to protein C
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Factor VIII
This LMWH is administered in mg, as opposed to anti factor Xa units
synthetic form of heparin
Low molecular weight heparin inhibits this factor
UFH
This parenterally administered drug should not be used intramuscularly
This racemic mixture has a long halflife and has 100% bioavailability
use the aPTT to measure the drug use
clopidogrel and ticlopidine act on this receptor
Serine protease inhibitor that inactivates clotting factors
these vitamin facilitate clotting
Factor I
ATIII inactivates these 3 clotting factors (answer in numerical order)
the famous indirect thrombin inhibitor, can induce thrombocytopenia
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
abciximab and eptifibatide and tirofiban act on this receptor
this antagonist is used to reverse heparin
These proteins are endogenous anticoagulants
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These factors facilitate clotting
A vit K dependent serine protease that is activated by thrombin to APC
isolated from leech saliva, bivalent irreversible thrombin inhibitor
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This vitamin K antagonist inhibits epoxide reductase
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
Factor VII
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
the oral standard long term therapy
allergy, alopecia, and osteoporosis are secondary side effects of this drug
heparin should not be given to pregnant or breast feeding because of this solution
Factor IV
recombinant form of hirudin used for HIT, beware of renal insufficiency
these blood disorders are treated by anticoagulants
These three bivalent DTIs also bind to the substrate site
Serine protease inhibitor that inhibits plasmin
irudin and gatro are suffixes for this class
DTI used for HIT, beware of liver, increases INRs
Factor II
if the pt has HIT, switch to this drug
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
WISN
this enzyme degrades many blood plasma proteins, most notably, the clot
enoxaparin, dalteparin, and tinzaparin are types of this drug
Long half life, low side effects, less frequent dosing are traits of this heparin modification
HIT
The effects of WISN are caused by a decrease in activity of this protein

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