Lin Day 1

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Can you name the Lin Day 1?

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Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
A vit K dependent serine protease that is activated by thrombin to APC
isolated from leech saliva, bivalent irreversible thrombin inhibitor
heparin's half life in hours
This LMWH is administered in mg, as opposed to anti factor Xa units
This vitamin K antagonist inhibits epoxide reductase
Factor II
DTI used for HIT, beware of liver, increases INRs
Factor IX
Serine protease inhibitor that inhibits plasmin
The effects of WISN are caused by a decrease in activity of this protein
ATIII inactivates these 3 clotting factors (answer in numerical order)
these blood disorders are treated by anticoagulants
Serine protease inhibitor that inactivates clotting factors
recombinant form of hirudin used for HIT, beware of renal insufficiency
Factor X
Factor I
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
if the pt has HIT, switch to this drug
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
use the aPTT to measure the drug use
These factors facilitate clotting
irudin and gatro are suffixes for this class
this antagonist is used to reverse heparin
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Low molecular weight heparin inhibits this factor
clopidogrel and ticlopidine act on this receptor
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
enoxaparin, dalteparin, and tinzaparin are types of this drug
Factor IV
These proteins are endogenous anticoagulants
these vitamin facilitate clotting
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
allergy, alopecia, and osteoporosis are secondary side effects of this drug
this enzyme degrades many blood plasma proteins, most notably, the clot
This racemic mixture has a long halflife and has 100% bioavailability
heparin can clear lipemia by increasing the level of this enzyme
abciximab and eptifibatide and tirofiban act on this receptor
This parenterally administered drug should not be used intramuscularly
Factor VIII
heparin should not be given to pregnant or breast feeding because of this solution
This proteins free form acts as a cofactor to protein C
synthetic form of heparin
These three bivalent DTIs also bind to the substrate site
Long half life, low side effects, less frequent dosing are traits of this heparin modification
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
Direct Thrombin Inhibitor, an oral prodrug
This occurs if heparin is given intramuscularly
Factor VII
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
the oral standard long term therapy

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