Lin Day 1

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Can you name the Lin Day 1?

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This racemic mixture has a long halflife and has 100% bioavailability
These proteins are endogenous anticoagulants
this enzyme degrades many blood plasma proteins, most notably, the clot
Serine protease inhibitor that inactivates clotting factors
heparin should not be given to pregnant or breast feeding because of this solution
heparin's half life in hours
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Factor IV
Factor II
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
use the aPTT to measure the drug use
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
Factor X
Factor I
enoxaparin, dalteparin, and tinzaparin are types of this drug
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
abciximab and eptifibatide and tirofiban act on this receptor
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
synthetic form of heparin
Factor VII
DTI used for HIT, beware of liver, increases INRs
This parenterally administered drug should not be used intramuscularly
These factors facilitate clotting
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
Direct Thrombin Inhibitor, an oral prodrug
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
This LMWH is administered in mg, as opposed to anti factor Xa units
Long half life, low side effects, less frequent dosing are traits of this heparin modification
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allergy, alopecia, and osteoporosis are secondary side effects of this drug
these vitamin facilitate clotting
Serine protease inhibitor that inhibits plasmin
This proteins free form acts as a cofactor to protein C
irudin and gatro are suffixes for this class
This vitamin K antagonist inhibits epoxide reductase
A vit K dependent serine protease that is activated by thrombin to APC
These three bivalent DTIs also bind to the substrate site
recombinant form of hirudin used for HIT, beware of renal insufficiency
clopidogrel and ticlopidine act on this receptor
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
this antagonist is used to reverse heparin
if the pt has HIT, switch to this drug
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
WISN
The effects of WISN are caused by a decrease in activity of this protein
UFH
heparin can clear lipemia by increasing the level of this enzyme
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Low molecular weight heparin inhibits this factor
the oral standard long term therapy
This occurs if heparin is given intramuscularly
Factor IX
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor VIII
HIT
ATIII inactivates these 3 clotting factors (answer in numerical order)
these blood disorders are treated by anticoagulants

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Created Nov 24, 2010ReportNominate
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