Lin Day 1

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Can you name the Lin Day 1?

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Vitamin K dependent glycoprotein, has two forms, free and c4b bound
This racemic mixture has a long halflife and has 100% bioavailability
These proteins are endogenous anticoagulants
heparin can clear lipemia by increasing the level of this enzyme
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
This occurs if heparin is given intramuscularly
isolated from leech saliva, bivalent irreversible thrombin inhibitor
These three bivalent DTIs also bind to the substrate site
This proteins free form acts as a cofactor to protein C
use the aPTT to measure the drug use
these blood disorders are treated by anticoagulants
Factor II
this enzyme degrades many blood plasma proteins, most notably, the clot
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
This parenterally administered drug should not be used intramuscularly
the oral standard long term therapy
This LMWH is administered in mg, as opposed to anti factor Xa units
These factors facilitate clotting
Direct Thrombin Inhibitor, an oral prodrug
heparin should not be given to pregnant or breast feeding because of this solution
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
clopidogrel and ticlopidine act on this receptor
the famous indirect thrombin inhibitor, can induce thrombocytopenia
Factor IX
The effects of WISN are caused by a decrease in activity of this protein
allergy, alopecia, and osteoporosis are secondary side effects of this drug
abciximab and eptifibatide and tirofiban act on this receptor
irudin and gatro are suffixes for this class
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these vitamin facilitate clotting
This vitamin K antagonist inhibits epoxide reductase
Factor IV
Factor X
this antagonist is used to reverse heparin
DTI used for HIT, beware of liver, increases INRs
if the pt has HIT, switch to this drug
ATIII inactivates these 3 clotting factors (answer in numerical order)
recombinant form of hirudin used for HIT, beware of renal insufficiency
WISN
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Serine protease inhibitor that inactivates clotting factors
HIT
Low molecular weight heparin inhibits this factor
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
heparin's half life in hours
UFH
Long half life, low side effects, less frequent dosing are traits of this heparin modification
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
Serine protease inhibitor that inhibits plasmin
Factor I
Factor VIII
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
synthetic form of heparin
enoxaparin, dalteparin, and tinzaparin are types of this drug
Factor VII
A vit K dependent serine protease that is activated by thrombin to APC
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis

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Created Nov 24, 2010ReportNominate
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