Lin Day 1

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Can you name the Lin Day 1?

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This parenterally administered drug should not be used intramuscularly
heparin's half life in hours
Factor I
This LMWH is administered in mg, as opposed to anti factor Xa units
These proteins are endogenous anticoagulants
Low molecular weight heparin inhibits this factor
Factor IV
This proteins free form acts as a cofactor to protein C
HIT
This vitamin K antagonist inhibits epoxide reductase
These three bivalent DTIs also bind to the substrate site
recombinant form of hirudin used for HIT, beware of renal insufficiency
UFH
Serine protease inhibitor that inactivates clotting factors
this drug, mediated by antithrombin, inactivates many intrinsic clotting factors, especially IIa and Xa
a bivalent reversible thrombin inhibitor that inhibits platelet activation, administered with IV, rapid on/off action
low platelet count, new thrombus, and thrombocytopenia should make you suspicious of this side effect of a indirect thrombin inhibitor
heparin can clear lipemia by increasing the level of this enzyme
irudin and gatro are suffixes for this class
Vitamin K dependent glycoprotein, has two forms, free and c4b bound
This drug is a mixture of sulfated mucopolysaccharides extracted from porcine gut or bovine lung
Factor VII
This anticoagulant can cross the placenta and cause hemorrhage and serious birth defect in the fetus
a synthetic pentasaccharide with long half life, indirect thrombin inhibitor
these vitamin facilitate clotting
ATIII inactivates these 3 clotting factors (answer in numerical order)
this enzyme degrades many blood plasma proteins, most notably, the clot
if the pt has HIT, switch to this drug
xxx
Direct Thrombin Inhibitor, an oral prodrug
isolated from leech saliva, bivalent irreversible thrombin inhibitor
Factor VIII
abciximab and eptifibatide and tirofiban act on this receptor
This racemic mixture has a long halflife and has 100% bioavailability
these blood disorders are treated by anticoagulants
allergy, alopecia, and osteoporosis are secondary side effects of this drug
The effects of WISN are caused by a decrease in activity of this protein
Factor II
heparin should not be given to pregnant or breast feeding because of this solution
use the aPTT to measure the drug use
Degrades cofactor Va and VIIIa, deficiency in this protein can result in increased thrombosis
These factors facilitate clotting
A vit K dependent serine protease that is activated by thrombin to APC
WISN
Blocks the gamma carboxylation of the glutamate residue in prothrombin (II), VII, IX, X, protein C and S
the famous indirect thrombin inhibitor, can induce thrombocytopenia
enoxaparin, dalteparin, and tinzaparin are types of this drug
clopidogrel and ticlopidine act on this receptor
DTI used for HIT, beware of liver, increases INRs
Factor IX
synthetic form of heparin
the oral standard long term therapy
Serine protease inhibitor that inhibits plasmin
Factor X
Long half life, low side effects, less frequent dosing are traits of this heparin modification
This occurs if heparin is given intramuscularly
this antagonist is used to reverse heparin

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