| Child(ren) | President |
| Harriet Lane (orpaned niece whom he raised) | |
| John William 'Jack', James Earl 'Chip', 'Donnell' Jeffrey, Amy Lynn | |
| Benjamin | |
| John Payne Todd (Wife's from previous marriage) | |
| Russell Benjamin, Mary Scott 'Mamie' Elizabeth | |
| Frederick Dent, Ulysses 'Buck', Ellen 'Nellie' Wrenshall, Jesse Root | |
| Margaret Woodrow, Jessie Woodrow, Eleanor Randalph | |
| Chelsea Victoria | |
| Caroline, John | |
| Malia, Natasha 'Sasha' | |
| John Sheldon Doud | |
| Maureen, Michael, Patti, Ronald Prescott, | |
| 'Mary' Margaret | |
| George Walker, John E. 'Jeb', Neil M, Marvin P., Dorothy 'Doro' Walker | |
| Chester Alan, Ellen 'Nell' Herndon | |
| Sardis Birchard, James Webb, Rutherford Platt, Frances 'Fanny', Scott Russell | |
| George Washington, John, Charles Francis | |
| John, Calvin | |
| Abraham, John, Martin, Smith Thompson | |
| Abigail, John, Charles, Thomas | |
| Ann Mackall, Sarah Knox, Mary Elizabeth 'Betty', Richard 'Dick' | |
| Eliza, Maria Hester | |
| | Child(ren) | President |
| None | |
| Herbert, Allan | |
| Andrew (adopted nephew), Lyncoya (adopted niece). Guardian of: John Donelson, Daniel Donelson, Andrew Donelson, Andrew Hutchings, Carolina Butler, Eliza Butler, Edward Butler, Anth | |
| Robert Alphonso, Helen Herron, Charles Phelps | |
| Mary, Robert, John, Letitia, Elizabeth, Alice, Tazewell, David Gardiner 'Gardie', John Alexander, Julia Gardiner, Lachlan, Lyon Gardiner, Robert Fitzwalter 'Fitz', Pearl | |
| Ruth, Esther, Marion, Richard Folsom, Francis Grover | |
| Michael Gerald, John 'Jack' Gardner, Steven Meigs, Susan Elizabeth | |
| Martha, Charles, Mary, Robert, Andrew | |
| Jenna, Barbara | |
| Robert Todd, William 'Willie' Wallace, Thomas 'Tad', Edward Baker | |
| Lynda Bird, Luci Baines | |
| Elizabeth Ann Christian (From extramarital affair) | |
| Patricia 'Tricia, Julie | |
| Alice, Theodore, Kermit, Ethel Carow, Archibald Bulloch, Quentin | |
| Elizabeth 'Betsey' Bassett, John Cleves Symmes, Lucy Singleton, William Henry, John Scott, Benjamin, Mary Symmes, Carter Bassett, Anna Tuthill | |
| John Parke, Martha Parke (Adopted from wife's previous marriage) | |
| Martha 'Patsy', Mary 'Polly' | |
| Millard Powers, Mary Abigail | |
| Katherine 'Katie', Ida. (Both died in infancy) | |
| Anna Eleanor, James, Elliott, Franklin, John Aspinwall | |
| Harry Augustus, James Rudolph, Mary 'Mollie', Irvin McDowell, Abram | |
|