Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Skin DiseaseTetracycline often applied topically to cure
ArthopodsMite burrows into epidermis. Papular eruption.
Side EffectTetracyclin forms ROS causing damage
FungusCaused by Yeast
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
BacteriaSusceptible to Linezolid but not vancomycin
BacteriaOften cause gut infection after oral broad spectrum antibiotic
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
FungusCan be oral or vaginal. Often treated with oral miconazole.
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
Side EffectPenicillin can cause this in about 5% of people
VirusT cells increase but there are less T cells
AreaDiseaseClue
VirusHemaglutinnin, Neuraminidase, ...
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
VirusMost common cold causer
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
Side EffectDeath after Chloramphenicol
InflammationHomocysteine implicated
FungusCaused by trichophyton (mould) often
Risk Factor - BacteriaCo-morbidity with ATS
Virus/InflammationRibavirin used, can be caused by alcohol
Side EffectAminoglycoside SE
FungusMore common where earth is being moved. In lungs.
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
ArthopodsScalp itching
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
ArthopodsItching in Pubic Area
VirusCauses SARS
Risk FactorIncreases risk of ATS

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