Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Risk Factor - BacteriaCo-morbidity with ATS
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
ArthopodsItching in Pubic Area
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
BacteriaSusceptible to Linezolid but not vancomycin
Side EffectPenicillin can cause this in about 5% of people
ArthopodsMite burrows into epidermis. Papular eruption.
VirusCauses SARS
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Risk FactorIncreases risk of ATS
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Skin DiseaseTetracycline often applied topically to cure
Side EffectTetracyclin forms ROS causing damage
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
VirusT cells increase but there are less T cells
Side EffectAminoglycoside SE
AreaDiseaseClue
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Side EffectDeath after Chloramphenicol
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
FungusCan be oral or vaginal. Often treated with oral miconazole.
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
VirusMost common cold causer
FungusCaused by trichophyton (mould) often
ArthopodsScalp itching
InflammationHomocysteine implicated
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
VirusHemaglutinnin, Neuraminidase, ...
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
FungusMore common where earth is being moved. In lungs.
Virus/InflammationRibavirin used, can be caused by alcohol
FungusCaused by Yeast

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