Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Risk FactorIncreases risk of ATS
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
FungusMore common where earth is being moved. In lungs.
ArthopodsMite burrows into epidermis. Papular eruption.
InflammationHomocysteine implicated
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
VirusT cells increase but there are less T cells
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
FungusCan be oral or vaginal. Often treated with oral miconazole.
Risk Factor - BacteriaCo-morbidity with ATS
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
ArthopodsScalp itching
Side EffectPenicillin can cause this in about 5% of people
VirusMost common cold causer
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
BacteriaOften cause gut infection after oral broad spectrum antibiotic
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
VirusCauses SARS
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
AreaDiseaseClue
Virus/InflammationRibavirin used, can be caused by alcohol
FungusCaused by Yeast
Side EffectAminoglycoside SE
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
Side EffectTetracyclin forms ROS causing damage
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
BacteriaSusceptible to Linezolid but not vancomycin
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
FungusCaused by trichophyton (mould) often
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
VirusHemaglutinnin, Neuraminidase, ...
Skin DiseaseTetracycline often applied topically to cure
ArthopodsItching in Pubic Area
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
Side EffectDeath after Chloramphenicol

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