If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Caused by trichophyton (mould) often
Neutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
Often susceptible to vancomycin and linezolid but resistant to Methicillin
Neutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
More common where earth is being moved. In lungs.
Often cause gut infection after oral broad spectrum antibiotic
ABCA1 doesn't work so ApoA1 can't pick up cholesterol
T cells increase but there are less T cells
Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.