Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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FungusCaused by Yeast
FungusCan be oral or vaginal. Often treated with oral miconazole.
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
Side EffectDeath after Chloramphenicol
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
ArthopodsItching in Pubic Area
ArthopodsScalp itching
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
Side EffectPenicillin can cause this in about 5% of people
VirusHemaglutinnin, Neuraminidase, ...
Virus/InflammationRibavirin used, can be caused by alcohol
InflammationHomocysteine implicated
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
VirusT cells increase but there are less T cells
BacteriaSusceptible to Linezolid but not vancomycin
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
ArthopodsMite burrows into epidermis. Papular eruption.
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
VirusMost common cold causer
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
Risk Factor - BacteriaCo-morbidity with ATS
Skin DiseaseTetracycline often applied topically to cure
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
Side EffectAminoglycoside SE
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
VirusCauses SARS
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
FungusMore common where earth is being moved. In lungs.
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
FungusCaused by trichophyton (mould) often
Side EffectTetracyclin forms ROS causing damage
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Risk FactorIncreases risk of ATS
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium

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