S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
Neutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
Short stage in blood then muscle (esp. heart).
Ribavirin used, can be caused by alcohol
Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Susceptible to Linezolid but not vancomycin
Often cause gut infection after oral broad spectrum antibiotic
They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
More common where earth is being moved. In lungs.
Neutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
Penicillin can cause this in about 5% of people
T cells increase but there are less T cells
ABCA1 doesn't work so ApoA1 can't pick up cholesterol
Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
Recurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
Susceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Cefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...