Science / Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
ArthopodsScalp itching
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Side EffectAminoglycoside SE
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
ArthopodsMite burrows into epidermis. Papular eruption.
Virus/InflammationRibavirin used, can be caused by alcohol
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
VirusCauses SARS
FungusCaused by Yeast
Skin DiseaseTetracycline often applied topically to cure
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
FungusCaused by trichophyton (mould) often
Side EffectDeath after Chloramphenicol
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
FungusCan be oral or vaginal. Often treated with oral miconazole.
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
VirusT cells increase but there are less T cells
BacteriaSusceptible to Linezolid but not vancomycin
Risk FactorIncreases risk of ATS
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
VirusHemaglutinnin, Neuraminidase, ...
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
FungusMore common where earth is being moved. In lungs.
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
VirusMost common cold causer
Side EffectTetracyclin forms ROS causing damage
Side EffectPenicillin can cause this in about 5% of people
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
InflammationHomocysteine implicated
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
ArthopodsItching in Pubic Area
Risk Factor - BacteriaCo-morbidity with ATS

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