Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Th2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
Susceptible to Linezolid but not vancomycin
S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
Cefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Short stage in blood then muscle (esp. heart).
They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
Penicillin can cause this in about 5% of people
RF present but not Rheumatoid Arthritis. Often features in 'House'
Mite burrows into epidermis. Papular eruption.
Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Neutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
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