Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Side EffectTetracyclin forms ROS causing damage
VirusHemaglutinnin, Neuraminidase, ...
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
FungusCan be oral or vaginal. Often treated with oral miconazole.
Risk FactorIncreases risk of ATS
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
FungusCaused by Yeast
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
VirusCauses SARS
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
ArthopodsItching in Pubic Area
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Side EffectAminoglycoside SE
ArthopodsMite burrows into epidermis. Papular eruption.
Risk Factor - BacteriaCo-morbidity with ATS
Side EffectDeath after Chloramphenicol
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
AreaDiseaseClue
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
FungusCaused by trichophyton (mould) often
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
FungusMore common where earth is being moved. In lungs.
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
VirusT cells increase but there are less T cells
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
ArthopodsScalp itching
VirusMost common cold causer
InflammationHomocysteine implicated
Skin DiseaseTetracycline often applied topically to cure
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Virus/InflammationRibavirin used, can be caused by alcohol
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
BacteriaSusceptible to Linezolid but not vancomycin
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Side EffectPenicillin can cause this in about 5% of people

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