If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
Often susceptible to vancomycin and linezolid but resistant to Methicillin
Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
ABCA1 doesn't work so ApoA1 can't pick up cholesterol
Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Itching in Pubic Area
Susceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
Short stage in blood then muscle (esp. heart).
T cells increase but there are less T cells
Often cause gut infection after oral broad spectrum antibiotic