Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
Side EffectTetracyclin forms ROS causing damage
ArthopodsScalp itching
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
FungusCaused by trichophyton (mould) often
ArthopodsItching in Pubic Area
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
FungusCaused by Yeast
InflammationHomocysteine implicated
VirusCauses SARS
Virus/InflammationRibavirin used, can be caused by alcohol
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
VirusHemaglutinnin, Neuraminidase, ...
Side EffectDeath after Chloramphenicol
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Side EffectPenicillin can cause this in about 5% of people
AreaDiseaseClue
ArthopodsMite burrows into epidermis. Papular eruption.
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Side EffectAminoglycoside SE
VirusMost common cold causer
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling
Risk FactorIncreases risk of ATS
BacteriaOften cause gut infection after oral broad spectrum antibiotic
FungusMore common where earth is being moved. In lungs.
FungusCan be oral or vaginal. Often treated with oral miconazole.
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
Skin DiseaseTetracycline often applied topically to cure
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
BacteriaSusceptible to Linezolid but not vancomycin
Risk Factor - BacteriaCo-morbidity with ATS
VirusT cells increase but there are less T cells
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness

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