ABCA1 doesn't work so ApoA1 can't pick up cholesterol
Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
More common where earth is being moved. In lungs.
Cefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
LDLR doesn't recognise ApoA or ApoE
Caused by trichophyton (mould) often
Tetracyclin forms ROS causing damage
Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Increases risk of ATS
Recurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium