Diseases in Infection and Immunity

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Can you name the Diseases in Infection and Immunity?

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AreaDiseaseClue
FungusCan be oral or vaginal. Often treated with oral miconazole.
Skin DiseaseTetracycline often applied topically to cure
Side EffectTetracyclin forms ROS causing damage
InflammationHomocysteine implicated
Risk FactorIncreases risk of ATS
VirusT cells increase but there are less T cells
Side EffectAminoglycoside SE
FungusCaused by trichophyton (mould) often
FungusMore common where earth is being moved. In lungs.
Mendelian DisorderLDLR doesn't recognise ApoA or ApoE
VirusMost common cold causer
BacteriaOften cause gut infection after oral broad spectrum antibiotic
Side EffectDeath after Chloramphenicol
ArthopodsScalp itching
VirusHemaglutinnin, Neuraminidase, ...
BacteriaSusceptible to few drugs, often causes septicaemia. Susceptible to Ceftazidime, Cefoperazone, Cefepime, Cefpirome, Imipenem, Polymixins, Ciprofloxacin
Risk Factor - BacteriaCo-morbidity with ATS
Side EffectCan be caused by Clindamycin. Killing all susceptible bacteria in gut using a broad spectrum antibiotic can cause...
InflammationNeutrophil driven, often causes cyanosis, hypoxia and right heart failure. Mucous is a problem!
VirusCauses SARS
BacteriaOften susceptible to vancomycin and linezolid but resistant to Methicillin
AreaDiseaseClue
FungusCaused by Yeast
Immune DeficiencyRecurrent bacterial infections, no pus, Leukocytes don't adhere to endothelium
Parasite (Protozoa)Multiplies in blood and CSF disturbing circadian rythms. avoids immune system by using cyclical antigen coats.
Mendelian disorderABCA1 doesn't work so ApoA1 can't pick up cholesterol
ArthopodsItching in Pubic Area
InfectionIsoniazid/Ethambutol/Pyrazinamide/Rifampicin prescribed
InflammationChronic Inflammation, Synovium (Hyaluronan, PGE2), MMPs (TIMP & Serpin inactivation), TNFa, IL-1b, Pannus formation
Virus/InflammationRibavirin used, can be caused by alcohol
Parasite (Helminth)Egg dropped in faeces and mature in soil. they are ingested and hatch in intestine. they penetrate the gut wall and migrate to liver then heart then lung. they grow and are then coughed up and swallowed.10-30cm adult can escape from any orifice though larval migration causes most morbidity.
Parasite (Helminth)If humans are primary host, no morbidity. Worm just stays in gut. Intermediate host causes morbidity as organism in tissues
InflammationTh2 (IL-4,5 & 13) and Eosinophil driven. Hyperresponsiveness
BacteriaSusceptible to Linezolid but not vancomycin
Parasite (Helminth)S. mansoni, S. haematobium, S. japonicus. Use water snail as intermediate host (can also have secondary host)
Infection/InflammationCefotaxime/Ceftriaxone often prescribed. Caused by N. meningitidis, H. influenzae, S. pneumoniae, L. monocytogenes, possible C. albicans...
Parasite (Protozoa)Short stage in blood then muscle (esp. heart).
Parasite (Protozoa)They multiply in Liver then RBCs. Can cause severe anaemia, haemolysis, pulmonary oedema, metabolic acidosis and hypoglycaemia. Most serious in P. falciparum
Side EffectPenicillin can cause this in about 5% of people
Systemic InflammationRF present but not Rheumatoid Arthritis. Often features in 'House'
ArthopodsMite burrows into epidermis. Papular eruption.
Parasite (Helminth)Live in subcutaneous tissue and lymphatic tissue. Adults discharge tiny babies which can be ingested by insects. Can cause Elephantiasis and River Blindness.
Immune DeficiencyNeutrophilia, no pus, defective fucose metabolism (affects selectins), decreased rolling

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