| Function | Amino acid | Additional information |
| Source of amino groups in transamination reactions | |
| Form of activated ammonium ions, source of ammonium in the kidney | |
| Predominant circulating amino acid with the LARGER molecular mass, used in amino group transport | |
| Formed in mitochondria during urea cycle by transfer of carbamoyl group | |
| One of the three amino acids involved in creatine biosynthesis | |
| Reacts with ATP to form SAM, an important source of methyl groups for methylation reactions | |
| Reactant in ammonia fixation | |
| Directly INCORPORATED during de novo synthesis of purines | |
| Amino group donor in purine biosynthesis (does NOT get incorporated!) | |
| Precursor to the neurotransmitter serotonin | |
| Source of GABA, the primary inhibitory neurotransmitter in the CNS | |
| Initial reactant for nonessential amino acid tyrosine's synthesis | |
| Source of one-carbon fragments used in biosynthesis | |
| Precursor to the vitamin niacin | |