| Cause of Death | Murdered Character |
| The character whose death is the first image of the first show ('If ____ always stole the money, why'd you let him play?') | |
| Omar's boyfriend, killed for his part in robbing the Barksdale stash house | |
| Barksdale enforcer, shot by Omar as revenge for the murder of the above character | |
| Low level drug dealer, shot by Bodie and Poot on orders from Stringer | |
| Strip club owner, killed by Wee-Bey and Little Man for cooperating with the police | |
| Drug dealer, murdered in prison on orders from Stringer Bell | |
| Warehouse owner who acted as a fence for the Greeks; shot to death by Ziggy Sobotka | |
| Secretary treasurer for the International Brotherhood of Stevedores; murdered by the Greeks for cooperating with the police | |
| Drug kingpin, shot by Omar and Brother Mouzone | |
| | Cause of Death | Murdered Character |
| Stanfield drug dealer, shot by the character listed below due to his jealousy over him dating his ex-girlfriend | |
| Drug dealer in Bodie's crew, murdered by Chris Partlow for killing the above character | |
| Drug dealer, shot to death by O-Dog on orders from Marlo, after he was seen talking to McNulty | |
| Blind advisor to Omar, tortured and murdered by Chris and Snoop | |
| Leader of the New Day Co-Op, shot by Chris Partlow while Marlo watched | |
| Stick-up artist, shot by Kenard while buying cigarettes | |
| Stanfield enforcer, shot by Michael Lee | |
| Drug dealer, shot in the head by Slim Charles in the final episode of the show | |
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