| Hint | Vocabulary Word |
| Boundary established by Pope Alexander VI in 1493 about 300 miles west of the Azores; gave unclaimed land west of the line to Spain, and east of the line to Portugal | |
| a royal governor in Spanish america | |
| narrow, winding sea passage | |
| Transfer of plants, animals, and diseases between the Americas and Europe, Asia, and Africa | |
| to change beliefs | |
| Spanish soldiers and explorers who led military expeditions in the Americas and captured land for Spain | |
| settlements established by priests in Spanish America to convert local Indians to Catholicism | |
| To sail completely around something | |
| an epidemic that spread through Europe from 1348 to about 1350 that killed as many as 75 million people | |
| a nonexistent path through North America that early explorers searched for hoping that it would allow ships to sail from the Atlantic to the Pacific Ocean | |
| Centuries long struggle to drive Moors from Spain; ended in 1492 with the surrender of the kingdom of Granada | |