| President's Spouse(s) | President's Name | Acting First Lady's Relationship: Name |
| Jane Means Appleton | |
| Margaret 'Peggy' Mackall Smith | |
| (1) Abigail Powers (2) Caroline Carmichael | |
| Elizabeth 'Eliza' Kortright | |
| Florence Kling | |
| Martha Wayles | |
| Abigail Smith | |
| Barbara Pierce | |
| Laura Welch | |
| Thelma 'Pat' Patricia Ryan | |
| Elizabeth 'Bess' Virginia Wallace | |
| Jacqueline 'Jackie' Lee Bouvier | |
| No Wife | |
| (1) Letitia Christian (2) Julia Gardiner | |
| Rachel Donelson | |
| Ellen 'Nell' Lewis Herndon | |
| Eliza McCardle | |
| Mary 'Mamie' Geneva Doud | |
| (1) Alice Hathaway Lee (2) Edith Kermit Cardow | |
| Anna Tuthill Symmes | |
| Claudia 'Lady Bird' Alta Taylor | |
| Frances Folsom | |